Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | geminin, DNA replication inhibitor | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Brugia malayi | Hypothetical 65.5 kDa Trp-Asp repeats containing protein F02E8.5 inchromosome X | geminin, DNA replication inhibitor | 209 aa | 176 aa | 27.8 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | geminin | 0.0205 | 1 | 1 |
Loa Loa (eye worm) | ryanodine receptor | 0.0062 | 0.1836 | 0.4255 |
Schistosoma mansoni | hypothetical protein | 0.0205 | 1 | 1 |
Trypanosoma brucei | inositol 1,4,5-trisphosphate receptor | 0.006 | 0.1711 | 0.5 |
Echinococcus granulosus | ryanodine receptor 44f | 0.0135 | 0.6025 | 0.3009 |
Brugia malayi | Ryanodine Receptor TM 4-6 family protein | 0.0167 | 0.7853 | 1 |
Schistosoma mansoni | inositol 145-trisphosphate receptor | 0.0051 | 0.1184 | 0.0605 |
Echinococcus multilocularis | ryanodine receptor 44f | 0.0135 | 0.6025 | 0.3009 |
Schistosoma mansoni | ryanodine receptor related | 0.0167 | 0.7853 | 0.7712 |
Loa Loa (eye worm) | hypothetical protein | 0.0032 | 0.0076 | 0.0175 |
Leishmania major | hypothetical protein, conserved | 0.0041 | 0.0602 | 0.5 |
Trypanosoma cruzi | inositol 1,4,5-trisphosphate receptor, putative | 0.006 | 0.1711 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0205 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0106 | 0.4314 | 1 |
Loa Loa (eye worm) | ryanodine receptor | 0.0039 | 0.0515 | 0.1193 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 0.1122 uM | PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in SW480 colon adenocarcinoma cells. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 18.526 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Potency (functional) | 20.5962 uM | PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in MCF 10a normal breast cells. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 23.9341 uM | PUBCHEM_BIOASSAY: qHTS profiling assay for firefly luciferase inhibitor/activator using purified enzyme and Km concentrations of substrates (counterscreen for miR-21 project). (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID2288, AID2289, AID2598, AID411] | ChEMBL. | No reference |
Potency (functional) | 47.7548 uM | PubChem BioAssay. qHTS Assay to Find Inhibitors of Pin1. (Class of assay: confirmatory) | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Plasmodium falciparum | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.