Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | follicle stimulating hormone receptor | 0.0229 | 0.2617 | 1 |
Echinococcus granulosus | lysine specific histone demethylase 1A | 0.0111 | 0.1188 | 0.1371 |
Echinococcus granulosus | lysine specific histone demethylase 1A | 0.0111 | 0.1188 | 0.1371 |
Echinococcus multilocularis | voltage dependent L type calcium channel subunit | 0.0161 | 0.1797 | 0.1797 |
Echinococcus multilocularis | 0.0111 | 0.1188 | 0.1188 | |
Brugia malayi | SWIRM domain containing protein | 0.0111 | 0.1188 | 0.454 |
Loa Loa (eye worm) | hypothetical protein | 0.0111 | 0.1188 | 0.454 |
Echinococcus granulosus | voltage dependent calcium channel type d subunit|voltage dependent calcium channel alpha 1 | 0.0161 | 0.1797 | 0.2073 |
Schistosoma mansoni | high voltage-activated calcium channel Cav1 | 0.0161 | 0.1797 | 0.1797 |
Echinococcus multilocularis | lysine specific histone demethylase 1A | 0.0111 | 0.1188 | 0.1188 |
Loa Loa (eye worm) | hypothetical protein | 0.0049 | 0.0448 | 0.1713 |
Schistosoma mansoni | amine oxidase | 0.0111 | 0.1188 | 0.1188 |
Loa Loa (eye worm) | hypothetical protein | 0.0111 | 0.1188 | 0.454 |
Trypanosoma brucei | Voltage-dependent calcium channel subunit, putative | 0.0056 | 0.053 | 0.5 |
Brugia malayi | hypothetical protein | 0.0111 | 0.1188 | 0.454 |
Loa Loa (eye worm) | calcium channel | 0.0161 | 0.1797 | 0.6865 |
Schistosoma mansoni | amine oxidase | 0.0111 | 0.1188 | 0.1188 |
Onchocerca volvulus | 0.0111 | 0.1188 | 1 | |
Trypanosoma cruzi | UDP-galactopyranose mutase | 0.0111 | 0.1188 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0111 | 0.1188 | 0.454 |
Echinococcus granulosus | voltage dependent calcium channel | 0.0161 | 0.1797 | 0.2073 |
Loa Loa (eye worm) | voltage-dependent calcium channel | 0.0056 | 0.053 | 0.2025 |
Echinococcus multilocularis | voltage dependent calcium channel type d subunit | 0.0161 | 0.1797 | 0.1797 |
Plasmodium falciparum | lysine-specific histone demethylase 1, putative | 0.0111 | 0.1188 | 0.5 |
Mycobacterium tuberculosis | Probable protoporphyrinogen oxidase HemY (protoporphyrinogen-IX oxidase) (protoporphyrinogenase) (PPO) | 0.0731 | 0.8665 | 1 |
Plasmodium falciparum | conserved Plasmodium protein, unknown function | 0.0111 | 0.1188 | 0.5 |
Plasmodium vivax | protoporphyrinogen oxidase, putative | 0.0111 | 0.1188 | 0.5 |
Echinococcus multilocularis | voltage dependent calcium channel type d subunit | 0.0161 | 0.1797 | 0.1797 |
Plasmodium falciparum | protoporphyrinogen oxidase | 0.0111 | 0.1188 | 0.5 |
Echinococcus multilocularis | voltage dependent L type calcium channel subunit | 0.0161 | 0.1797 | 0.1797 |
Plasmodium vivax | hypothetical protein, conserved | 0.0111 | 0.1188 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0161 | 0.1797 | 0.6865 |
Plasmodium vivax | lysine-specific histone demethylase 1, putative | 0.0111 | 0.1188 | 0.5 |
Schistosoma mansoni | Protoporphyrinogen oxidase chloroplast/mitochondrial precursor | 0.0842 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0111 | 0.1188 | 0.454 |
Loa Loa (eye worm) | hypothetical protein | 0.0056 | 0.053 | 0.2025 |
Loa Loa (eye worm) | hypothetical protein | 0.0049 | 0.0448 | 0.1713 |
Leishmania major | UDP-galactopyranose mutase | 0.0111 | 0.1188 | 0.5 |
Trypanosoma cruzi | UDP-galactopyranose mutase | 0.0111 | 0.1188 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0111 | 0.1188 | 0.454 |
Echinococcus granulosus | voltage dependent calcium channel type d subunit|voltage dependent calcium channel|voltage dependent L type calcium channel subu | 0.0161 | 0.1797 | 0.2073 |
Brugia malayi | Voltage-gated calcium channel, L-type, alpha subunit. C. elegans egl-19 ortholog | 0.0161 | 0.1797 | 0.6865 |
Toxoplasma gondii | histone lysine-specific demethylase | 0.0111 | 0.1188 | 1 |
Echinococcus granulosus | voltage dependent L type calcium channel subunit|voltage dependent calcium channel | 0.0161 | 0.1797 | 0.2073 |
Plasmodium vivax | hypothetical protein, conserved | 0.0111 | 0.1188 | 0.5 |
Mycobacterium ulcerans | protoporphyrinogen oxidase | 0.0842 | 1 | 1 |
Toxoplasma gondii | histone lysine-specific demethylase LSD1/BHC110/KDMA1A | 0.0111 | 0.1188 | 1 |
Echinococcus granulosus | protoporphyrinogen oxidase | 0.0731 | 0.8665 | 1 |
Echinococcus multilocularis | protoporphyrinogen oxidase | 0.0842 | 1 | 1 |
Mycobacterium leprae | PROBABLE PROTOPORPHYRINOGEN OXIDASE HEMY (PROTOPORPHYRINOGEN-IX OXIDASE) (PROTOPORPHYRINOGENASE) (PPO) | 0.0842 | 1 | 0.5 |
Echinococcus granulosus | voltage dependent calcium channel | 0.0056 | 0.053 | 0.0612 |
Brugia malayi | follicle stimulating hormone receptor | 0.0229 | 0.2617 | 1 |
Schistosoma mansoni | voltage-gated cation channel | 0.0161 | 0.1797 | 0.1797 |
Echinococcus multilocularis | voltage dependent calcium channel | 0.0161 | 0.1797 | 0.1797 |
Schistosoma mansoni | Lysine-specific histone demethylase 1 | 0.0111 | 0.1188 | 0.1188 |
Schistosoma mansoni | high voltage-activated calcium channel Cav2A | 0.0161 | 0.1797 | 0.1797 |
Loa Loa (eye worm) | hypothetical protein | 0.0111 | 0.1188 | 0.454 |
Brugia malayi | amine oxidase, flavin-containing family protein | 0.0111 | 0.1188 | 0.454 |
Toxoplasma gondii | transporter, cation channel family protein | 0.0056 | 0.053 | 0.1104 |
Echinococcus multilocularis | voltage dependent calcium channel | 0.0161 | 0.1797 | 0.1797 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (binding) | Induction of PXR-mediated CYP3A4 gene expression in human HepG2 cells at 50 uM by RT-PCR analysis | ChEMBL. | 21141967 | |
Activity (binding) | Induction of PXR-mediated MDR1 gene expression in human HepG2 cells at 50 uM by RT-PCR analysis | ChEMBL. | 21141967 | |
FC (binding) | = 4 | Transactivation of PXR in human HepG2 cells assessed as induction of beta-galactosidase activity at 50 uM by luciferase reporter gene assay relative to control | ChEMBL. | 21141967 |
Inhibition (functional) | = 50 % | Immunomodulatory activity in mouse RAW264.7 cells assessed as inhibition of IL1-beta mRNA expression at 50 uM by RT-PCR analysis | ChEMBL. | 21141967 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.