Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | isocitrate dehydrogenase 1 (NADP+), soluble | Starlite/ChEMBL | No references |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0108 | 0.111 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0108 | 0.111 | 1 |
Echinococcus granulosus | lysine specific histone demethylase 1A | 0.0108 | 0.111 | 0.1282 |
Brugia malayi | SWIRM domain containing protein | 0.0108 | 0.111 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0108 | 0.111 | 1 |
Mycobacterium ulcerans | protoporphyrinogen oxidase | 0.0823 | 1 | 1 |
Echinococcus granulosus | protoporphyrinogen oxidase | 0.0715 | 0.8653 | 1 |
Plasmodium vivax | hypothetical protein, conserved | 0.0108 | 0.111 | 1 |
Echinococcus multilocularis | protoporphyrinogen oxidase | 0.0823 | 1 | 1 |
Schistosoma mansoni | amine oxidase | 0.0108 | 0.111 | 0.111 |
Mycobacterium leprae | PROBABLE PROTOPORPHYRINOGEN OXIDASE HEMY (PROTOPORPHYRINOGEN-IX OXIDASE) (PROTOPORPHYRINOGENASE) (PPO) | 0.0823 | 1 | 0.5 |
Trypanosoma brucei | isocitrate dehydrogenase [NADP], mitochondrial precursor, putative | 0.0019 | 0 | 0.5 |
Schistosoma mansoni | amine oxidase | 0.0108 | 0.111 | 0.111 |
Trypanosoma cruzi | UDP-galactopyranose mutase | 0.0108 | 0.111 | 1 |
Schistosoma mansoni | Lysine-specific histone demethylase 1 | 0.0108 | 0.111 | 0.111 |
Trypanosoma brucei | isocitrate dehydrogenase, putative | 0.0019 | 0 | 0.5 |
Schistosoma mansoni | Protoporphyrinogen oxidase chloroplast/mitochondrial precursor | 0.0823 | 1 | 1 |
Plasmodium vivax | lysine-specific histone demethylase 1, putative | 0.0108 | 0.111 | 1 |
Plasmodium falciparum | lysine-specific histone demethylase 1, putative | 0.0108 | 0.111 | 1 |
Toxoplasma gondii | histone lysine-specific demethylase LSD1/BHC110/KDMA1A | 0.0108 | 0.111 | 1 |
Mycobacterium tuberculosis | Probable protoporphyrinogen oxidase HemY (protoporphyrinogen-IX oxidase) (protoporphyrinogenase) (PPO) | 0.0715 | 0.8653 | 1 |
Mycobacterium tuberculosis | Conserved hypothetical protein | 0.0108 | 0.111 | 0.1282 |
Brugia malayi | hypothetical protein | 0.0108 | 0.111 | 1 |
Plasmodium falciparum | protoporphyrinogen oxidase | 0.0108 | 0.111 | 1 |
Plasmodium falciparum | conserved Plasmodium protein, unknown function | 0.0108 | 0.111 | 1 |
Echinococcus granulosus | lysine specific histone demethylase 1A | 0.0108 | 0.111 | 0.1282 |
Trypanosoma cruzi | UDP-galactopyranose mutase | 0.0108 | 0.111 | 1 |
Echinococcus multilocularis | lysine specific histone demethylase 1A | 0.0108 | 0.111 | 0.111 |
Toxoplasma gondii | histone lysine-specific demethylase | 0.0108 | 0.111 | 1 |
Brugia malayi | amine oxidase, flavin-containing family protein | 0.0108 | 0.111 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0108 | 0.111 | 1 |
Plasmodium vivax | protoporphyrinogen oxidase, putative | 0.0108 | 0.111 | 1 |
Onchocerca volvulus | 0.0108 | 0.111 | 0.5 | |
Mycobacterium tuberculosis | Possible oxidoreductase | 0.0108 | 0.111 | 0.1282 |
Loa Loa (eye worm) | hypothetical protein | 0.0108 | 0.111 | 1 |
Plasmodium vivax | hypothetical protein, conserved | 0.0108 | 0.111 | 1 |
Echinococcus multilocularis | 0.0108 | 0.111 | 0.111 | |
Loa Loa (eye worm) | hypothetical protein | 0.0108 | 0.111 | 1 |
Leishmania major | UDP-galactopyranose mutase | 0.0108 | 0.111 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 7.3753 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Potency (functional) | 16.3601 uM | PubChem BioAssay. qHTS for induction of synthetic lethality in tumor cells producing 2HG: qHTS for the HT-1080-NT fibrosarcoma cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 25.1189 uM | PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 100 uM | PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Plasmodium falciparum | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.