Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma cruzi | trans-sialidase, Group I, putative | 0.0171 | 0.1915 | 1 |
Trypanosoma cruzi | trans-sialidase, putative | 0.0171 | 0.1915 | 0.9998 |
Brugia malayi | Probable ClpP-like protease | 0.008 | 0.0476 | 0.0476 |
Trypanosoma cruzi | trans-sialidase, Group I, putative | 0.0171 | 0.1915 | 1 |
Mycobacterium leprae | PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) | 0.008 | 0.0476 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0173 | 0.1941 | 0.1941 |
Plasmodium falciparum | ATP-dependent Clp protease proteolytic subunit | 0.008 | 0.0476 | 0.5 |
Trypanosoma cruzi | trans-sialidase, putative | 0.0171 | 0.1915 | 0.9998 |
Schistosoma mansoni | microtubule-associated protein tau | 0.0671 | 0.9788 | 0.9788 |
Loa Loa (eye worm) | hypothetical protein | 0.008 | 0.0476 | 0.0476 |
Chlamydia trachomatis | ATP-dependent Clp protease proteolytic subunit | 0.008 | 0.0476 | 0.5 |
Trypanosoma cruzi | trans-sialidase, Group I, putative | 0.0171 | 0.1915 | 1 |
Trypanosoma brucei | trans-sialidase, putative | 0.0171 | 0.1915 | 1 |
Trypanosoma cruzi | trans-sialidase, Group I, putative | 0.0171 | 0.1915 | 1 |
Trypanosoma cruzi | trans-sialidase, Group I, putative | 0.0171 | 0.1915 | 1 |
Trypanosoma cruzi | trans-sialidase, putative | 0.0171 | 0.1915 | 1 |
Treponema pallidum | ATP-dependent Clp protease proteolytic subunit | 0.008 | 0.0476 | 0.5 |
Loa Loa (eye worm) | protein-tyrosine phosphatase | 0.0684 | 1 | 1 |
Mycobacterium ulcerans | ATP-dependent Clp protease proteolytic subunit | 0.008 | 0.0476 | 0.5 |
Schistosoma mansoni | protein tyrosine phosphatase non-receptor type nt1 | 0.0684 | 1 | 1 |
Trypanosoma cruzi | trans-sialidase, putative | 0.0171 | 0.1915 | 1 |
Trypanosoma cruzi | trans-sialidase, putative | 0.0171 | 0.1915 | 1 |
Echinococcus granulosus | peptidase Clp S14 family | 0.0052 | 0.0043 | 0.0043 |
Leishmania major | mitogen activated protein kinase, putative,map kinase, putative | 0.005 | 0 | 0.5 |
Echinococcus multilocularis | tyrosine protein phosphatase non receptor type | 0.0684 | 1 | 1 |
Echinococcus granulosus | microtubule associated protein 2 | 0.0671 | 0.9788 | 0.9788 |
Echinococcus granulosus | tyrosine protein phosphatase non receptor type | 0.0684 | 1 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0513 | 0.7307 | 1 |
Echinococcus multilocularis | peptidase Clp (S14 family) | 0.0052 | 0.0043 | 0.0043 |
Trypanosoma brucei | trans-sialidase, putative | 0.0171 | 0.1915 | 1 |
Chlamydia trachomatis | ATP-dependent Clp protease proteolytic subunit | 0.008 | 0.0476 | 0.5 |
Mycobacterium tuberculosis | Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2) | 0.0052 | 0.0043 | 0.5 |
Giardia lamblia | Kinase, CMGC MAPK | 0.005 | 0 | 0.5 |
Trypanosoma cruzi | trans-sialidase, putative | 0.0171 | 0.1915 | 0.9998 |
Trypanosoma cruzi | trans-sialidase, Group I, putative | 0.0171 | 0.1915 | 1 |
Trichomonas vaginalis | Sialidase-1 precursor, putative | 0.0513 | 0.7307 | 1 |
Schistosoma mansoni | peptidase Clp (S14 family) | 0.008 | 0.0476 | 0.0476 |
Echinococcus granulosus | geminin | 0.0173 | 0.1941 | 0.1941 |
Echinococcus granulosus | ATP dependent Clp protease proteolytic subunit | 0.008 | 0.0476 | 0.0476 |
Trypanosoma brucei | trans-sialidase, putative | 0.0171 | 0.1915 | 1 |
Echinococcus multilocularis | geminin | 0.0173 | 0.1941 | 0.1941 |
Echinococcus multilocularis | microtubule associated protein 2 | 0.0671 | 0.9788 | 0.9788 |
Trypanosoma cruzi | trans-sialidase, Group I, putative | 0.0171 | 0.1915 | 1 |
Trypanosoma cruzi | trans-sialidase, Group I, putative | 0.0171 | 0.1915 | 1 |
Trypanosoma cruzi | trans-sialidase, Group I, putative | 0.0171 | 0.1915 | 1 |
Toxoplasma gondii | ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein | 0.008 | 0.0476 | 1 |
Toxoplasma gondii | ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein | 0.008 | 0.0476 | 1 |
Trypanosoma cruzi | trans-sialidase, Group I, putative | 0.0171 | 0.1915 | 1 |
Leishmania major | mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 | 0.005 | 0 | 0.5 |
Wolbachia endosymbiont of Brugia malayi | ATP-dependent Clp protease proteolytic subunit | 0.008 | 0.0476 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0173 | 0.1941 | 0.1941 |
Trypanosoma cruzi | trans-sialidase, Group I, putative | 0.0171 | 0.1915 | 1 |
Plasmodium vivax | ATP-dependent Clp protease proteolytic subunit, putative | 0.008 | 0.0476 | 0.5 |
Trypanosoma brucei | trans-sialidase | 0.0171 | 0.1915 | 1 |
Echinococcus multilocularis | ATP dependent Clp protease proteolytic subunit | 0.008 | 0.0476 | 0.0476 |
Trypanosoma brucei | trans-sialidase, putative | 0.0171 | 0.1915 | 1 |
Mycobacterium tuberculosis | Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP) | 0.0052 | 0.0043 | 0.5 |
Trypanosoma cruzi | trans-sialidase, putative | 0.0171 | 0.1915 | 0.9998 |
Mycobacterium ulcerans | ATP-dependent Clp protease proteolytic subunit | 0.008 | 0.0476 | 0.5 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0319 | 0.4249 | 0.5815 |
Trypanosoma brucei | trans-sialidase, putative | 0.0171 | 0.1915 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Inhibition (binding) | Inhibition of human recombinant MAOA expressed in baculovirus-infected BTI insect cells at 100 uM after 15 mins by fluorimetric assay | ChEMBL. | 21194943 | |
Inhibition (binding) | Inhibition of human recombinant MAOB expressed in baculovirus-infected BTI insect cells at 100 uM after 15 mins by fluorimetric assay | ChEMBL. | 21194943 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.