Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Plasmodium vivax | acyl-CoA synthetase, putative | 0.0311 | 0.2525 | 0.5 |
Mycobacterium ulcerans | putative oxalyl-CoA decarboxylase | 0.0544 | 1 | 1 |
Mycobacterium ulcerans | acetolactate synthase 1 catalytic subunit | 0.0544 | 1 | 1 |
Schistosoma mansoni | acetolactate synthase | 0.0465 | 0.7458 | 0.5 |
Mycobacterium tuberculosis | Probable oxalyl-CoA decarboxylase OxcA | 0.0544 | 1 | 1 |
Mycobacterium tuberculosis | Probable acetolactate synthase IlvG (acetohydroxy-acid synthase)(ALS) | 0.0544 | 1 | 1 |
Mycobacterium leprae | Probable Acetolactate synthase IlvG (Acetohydroxy-acid synthase)(ALS) | 0.0544 | 1 | 0.5 |
Mycobacterium leprae | PROBABLE ACETOLACTATE SYNTHASE (LARGE SUBUNIT) ILVB (ACETOHYDROXY-ACID SYNTHASE) | 0.0544 | 1 | 0.5 |
Mycobacterium ulcerans | hypothetical protein | 0.0544 | 1 | 1 |
Leishmania major | putative pyruvate/indole-pyruvate carboxylase, putative | 0.0311 | 0.2525 | 0.5 |
Schistosoma mansoni | acetolactate synthase | 0.0465 | 0.7458 | 0.5 |
Plasmodium falciparum | acyl-CoA synthetase | 0.0311 | 0.2525 | 0.5 |
Loa Loa (eye worm) | ILVBL protein | 0.0329 | 0.3106 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | = 21.2 ug ml-1 | Cytotoxicity against human MCF7 cells assessed as loss of cell monolayers after 96 hrs | ChEMBL. | 21130542 |
IC50 (functional) | = 25.1 ug ml-1 | Cytotoxicity against human HepG2 cells assessed as loss of cell monolayers after 96 hrs | ChEMBL. | 21130542 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.