Detailed view for LmjF.34.3250

Basic information

TDR Targets ID: 29221
Leishmania major, putative pyruvate/indole-pyruvate carboxylase, putative
Source Database / ID:  TriTrypDB  GeneDB

pI: 5.9994 | Length (AA): 550 | MW (Da): 60261 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG2

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00205   Thiamine pyrophosphate enzyme, central domain
PF02775   Thiamine pyrophosphate enzyme, C-terminal TPP binding domain
PF02776   Thiamine pyrophosphate enzyme, N-terminal TPP binding domain

Gene Ontology

Mouse over links to read term descriptions.
GO:0030976   thiamin pyrophosphate binding  
GO:0016831   carboxy-lyase activity  
GO:0003824   catalytic activity  
GO:0000287   magnesium ion binding  

Metabolic Pathways

Tryptophan metabolism (KEGG)
Global map (KEGG)

Structural information

Modbase 3D models:

There are 6 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
1 550 1ozh (A) 7 557 19.00 0 1 1.12 -0.72
4 536 1ovm (A) 3 536 41.00 0 1 1.57 -1.33
2 550 5fem (A) 88 663 21.00 0 1 1.20668 -0.1
4 542 1ovm (A) 3 542 40.00 0 1 1.4855 -0.57
6 550 2wvg (A) 3 557 27.00 0 1 1.36871 -0.62
6 550 2vbi (A) 3 549 26.00 0 1 1.37871 -0.71

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

Upregulation Percent Ranking Stage Dataset
Upper 60-80% percentile amastigotes, metacyclic. Fernandes MC
Show/Hide expression data references
  • Fernandes MC Dual Transcriptome Profiling of Leishmania-Infected Human Macrophages Reveals Distinct Reprogramming Signatures.

Orthologs

Ortholog group members (OG5_129158)

Species Accession Gene Product
Arabidopsis thaliana AT4G33070   pyruvate decarboxylase 1
Arabidopsis thaliana AT5G01320   pyruvate decarboxylase 4
Arabidopsis thaliana AT5G01330   pyruvate decarboxylase-3
Arabidopsis thaliana AT5G54960   pyruvate decarboxylase-2
Candida albicans CaO19.12078   pyruvate decarboxylase
Candida albicans CaO19.10395   pyruvate decarboxylase
Candida albicans CaO19.4608   pyruvate decarboxylase
Candida albicans CaO19.2877   pyruvate decarboxylase
Cryptosporidium hominis Chro.70351   TPP_enzymes_N, Thiamine pyrophosphate enzyme, N-terminal TPP binding domain
Cryptosporidium parvum cgd7_3120   pyruvate decarboxylase
Leishmania braziliensis LbrM.20.2830   putative pyruvate/indole-pyruvate carboxylase, putative
Leishmania donovani LdBPK_343030.1   Alpha-keto-acid decarboxylase, putative
Leishmania infantum LinJ.34.3030   putative pyruvate/indole-pyruvate carboxylase, putative
Leishmania major LmjF.34.3250   putative pyruvate/indole-pyruvate carboxylase, putative
Leishmania mexicana LmxM.33.3250   putative pyruvate/indole-pyruvate carboxylase, putative
Mycobacterium leprae ML2167   PROBABLE PYRUVATE OR INDOLE-3-PYRUVATE DECARBOXYLASE PDC
Mycobacterium tuberculosis Rv0853c   Probable pyruvate or indole-3-pyruvate decarboxylase Pdc
Mycobacterium ulcerans MUL_0302   pyruvate or indole-3-pyruvate decarboxylase Pdc
Oryza sativa 4339066   Os05g0469600
Oryza sativa 4332519   Os03g0293500
Oryza sativa 4324066   Os01g0160100
Oryza sativa 4339068   Os05g0469800
Oryza sativa 4344382   Os07g0693100
Saccharomyces cerevisiae YGR087C   indolepyruvate decarboxylase 6
Saccharomyces cerevisiae YLR044C   indolepyruvate decarboxylase 1
Saccharomyces cerevisiae YLR134W   indolepyruvate decarboxylase 5
Schmidtea mediterranea mk4.035992.00  

Essentiality

No essentiality data collected for this gene and/or its orthologs.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Druggability index (range: 0 to 1): 0.2

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
Species Target Length Identity Alignment span Linked Drugs Reference
Lolium rigidum Acetolactate synthase 516 aa 23.1% 463 aa Compounds References
Obtained from network model

Ranking Plot

Putative Drugs List

Compound Raw Global Species
0.0449 0.4858 1
0.0134 0.307 1
0.0205 0.4506 1
0.033 0.3914 1
0.0076 0.4677 1
0.0317 0.5333 1
0.0271 0.281 1
0.013 0.2531 1
0.0257 0.5211 1
0.0076 0.3143 1
0.0841 0.5661 1
0.0249 0.4994 1
0.0076 0.3611 1
0.014 0.4798 1
0.0249 0.4994 1
0.0213 0.2567 1
0.0249 0.4994 1
0.0689 0.5616 1
0.0139 0.4994 1
0.0261 0.2894 1
0.0249 0.4994 1
0.0076 0.2864 1
0.0249 0.4994 1
0.0152 0.2525 0.5
0.0325 0.3495 1
0.0249 0.4994 1
0.0076 0.4798 1
0.0448 0.4994 1
0.0576 0.5641 1
0.0138 0.4798 1
0.033 0.3914 1
0.0386 0.4994 1
0.0664 0.5588 1
0.0317 0.368 1
0.0249 0.4994 1
0.0221 0.5526 1
0.0134 0.4198 1
0.0127 0.4752 1
0.033 0.3914 1
0.0076 0.2525 1
0.0441 0.5511 1
0.0645 0.5652 1
0.0435 0.4994 1
0.0251 0.5452 1
0.0282 0.2722 1
0.0132 0.4798 1
0.0134 0.4798 1
0.0076 0.2525 0.5
0.044 0.5446 1
0.0073 0.368 0.5627
0.0122 0.4774 1
0.0205 0.535 1
0.0188 0.4798 1
0.0293 0.368 1
0.0311 0.2525 0.5
0.0249 0.4994 1
0.0126 0.4798 1
0.0191 0.5034 1
0.0125 0.4798 1
0.0257 0.5211 1
0.0251 0.5452 1
0.0317 0.5487 1
0.0148 0.5468 1
0.0195 0.4798 1
0.0131 0.4535 1
0.0282 0.2722 1
0.0338 0.4844 1
0.0076 0.2525 0.5
0.0131 0.4535 1
0.0249 0.4994 1
0.0131 0.3822 1
0.0249 0.4994 1
0.0186 0.5286 1
0.0249 0.4994 1
0.0514 0.5547 1
0.0257 0.5253 1
0.0076 0.368 1
0.0319 0.3116 1
0.0195 0.2689 1
0.0217 0.368 1
0.065 0.5582 1
0.0076 0.368 1
0.0249 0.4994 1
0.0192 0.5014 1
0.0076 0.2525 0.5
0.0249 0.4994 1
0.047 0.5471 1
0.0462 0.5397 1
0.0656 0.5586 1
0.0264 0.2525 0.5
0.0267 0.2853 1
0.0249 0.4994 1
0.0123 0.4994 1
0.0384 0.5581 1
0.0797 0.5608 1
0.0386 0.4264 1
0.0133 0.4759 1
0.0246 0.4994 1
0.0704 0.562 1
0.0457 0.3807 1
0.013 0.2531 1
0.0132 0.2525 0.5
0.0506 0.5475 1
0.0204 0.368 1
0.0146 0.256 1
0.0076 0.368 1
0.0221 0.5526 1
0.0125 0.2525 0.5
0.0147 0.4442 1
0.0793 0.5661 1
0.0076 0.3143 1
0.0253 0.2724 1
0.0249 0.4994 1
0.0076 0.2525 0.5
0.0662 0.5586 1
0.0249 0.4994 1
0.044 0.5446 1
0.0448 0.5521 1
0.0355 0.3463 1
0.0459 0.5438 1
0.0316 0.5357 1
0.0327 0.5325 1
0.0257 0.4798 1

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

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Gene identifier LmjF.34.3250 (Leishmania major), putative pyruvate/indole-pyruvate carboxylase, putative
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