Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | integrin, beta 2 (complement component 3 receptor 3 and 4 subunit) | Starlite/ChEMBL | References |
Homo sapiens | intercellular adhesion molecule 1 | References | |
Homo sapiens | integrin, alpha L (antigen CD11A (p180), lymphocyte function-associated antigen 1 | References |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Echinococcus multilocularis | integrin beta 2 | Get druggable targets OG5_127959 | All targets in OG5_127959 |
Brugia malayi | Integrin beta pat-3 precursor | Get druggable targets OG5_127959 | All targets in OG5_127959 |
Schistosoma mansoni | integrin beta subunit | Get druggable targets OG5_127959 | All targets in OG5_127959 |
Echinococcus granulosus | integrin beta 2 | Get druggable targets OG5_127959 | All targets in OG5_127959 |
Schistosoma japonicum | ko:K06464 integrin beta 2, putative | Get druggable targets OG5_127959 | All targets in OG5_127959 |
Schistosoma japonicum | Integrin beta-3 precursor, putative | Get druggable targets OG5_127959 | All targets in OG5_127959 |
Loa Loa (eye worm) | integrin beta-2 | Get druggable targets OG5_127959 | All targets in OG5_127959 |
Schistosoma japonicum | Integrin beta-PS precursor, putative | Get druggable targets OG5_127959 | All targets in OG5_127959 |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Toxoplasma gondii | histone lysine-specific demethylase LSD1/BHC110/KDMA1A | 0.0087 | 0 | 0.5 |
Loa Loa (eye worm) | integrin beta-2 | 0.0439 | 0.3904 | 0.3904 |
Schistosoma mansoni | integrin beta subunit | 0.0253 | 0.1835 | 0.2881 |
Leishmania major | UDP-galactopyranose mutase | 0.0087 | 0 | 0.5 |
Plasmodium vivax | hypothetical protein, conserved | 0.0087 | 0 | 0.5 |
Chlamydia trachomatis | protoporphyrinogen oxidase | 0.0662 | 0.6371 | 0.5 |
Brugia malayi | Integrin alpha cytoplasmic region family protein | 0.0112 | 0.0273 | 0.0273 |
Schistosoma mansoni | Protoporphyrinogen oxidase chloroplast/mitochondrial precursor | 0.0662 | 0.6371 | 1 |
Trypanosoma cruzi | UDP-galactopyranose mutase | 0.0087 | 0 | 0.5 |
Trypanosoma cruzi | UDP-galactopyranose mutase | 0.0087 | 0 | 0.5 |
Echinococcus multilocularis | protoporphyrinogen oxidase | 0.0662 | 0.6371 | 1 |
Plasmodium falciparum | lysine-specific histone demethylase 1, putative | 0.0087 | 0 | 0.5 |
Plasmodium falciparum | protoporphyrinogen oxidase | 0.0087 | 0 | 0.5 |
Plasmodium vivax | lysine-specific histone demethylase 1, putative | 0.0087 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0989 | 1 | 1 |
Echinococcus granulosus | integrin beta 2 | 0.0322 | 0.26 | 0.481 |
Onchocerca volvulus | 0.0087 | 0 | 0.5 | |
Toxoplasma gondii | histone lysine-specific demethylase | 0.0087 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0963 | 0.971 | 0.971 |
Echinococcus granulosus | protoporphyrinogen oxidase | 0.0575 | 0.5405 | 1 |
Mycobacterium leprae | PROBABLE PROTOPORPHYRINOGEN OXIDASE HEMY (PROTOPORPHYRINOGEN-IX OXIDASE) (PROTOPORPHYRINOGENASE) (PPO) | 0.0662 | 0.6371 | 0.5 |
Mycobacterium ulcerans | protoporphyrinogen oxidase | 0.0662 | 0.6371 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0112 | 0.0273 | 0.0273 |
Plasmodium falciparum | conserved Plasmodium protein, unknown function | 0.0087 | 0 | 0.5 |
Plasmodium vivax | hypothetical protein, conserved | 0.0087 | 0 | 0.5 |
Mycobacterium tuberculosis | Probable protoporphyrinogen oxidase HemY (protoporphyrinogen-IX oxidase) (protoporphyrinogenase) (PPO) | 0.0575 | 0.5405 | 1 |
Loa Loa (eye worm) | integrin alpha pat-2 | 0.0146 | 0.0656 | 0.0656 |
Echinococcus multilocularis | integrin beta 2 | 0.0322 | 0.26 | 0.4081 |
Plasmodium vivax | protoporphyrinogen oxidase, putative | 0.0087 | 0 | 0.5 |
Brugia malayi | Integrin beta pat-3 precursor | 0.0439 | 0.3904 | 0.3904 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.