Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | ATPase family, AAA domain containing 5 | Starlite/ChEMBL | No references |
Homo sapiens | SMAD family member 2 | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Loa Loa (eye worm) | transcription factor SMAD2 | Get druggable targets OG5_131716 | All targets in OG5_131716 |
Echinococcus multilocularis | atpase aaa+ type core atpase aaa type core | Get druggable targets OG5_139225 | All targets in OG5_139225 |
Brugia malayi | MH2 domain containing protein | Get druggable targets OG5_131716 | All targets in OG5_131716 |
Loa Loa (eye worm) | MH2 domain-containing protein | Get druggable targets OG5_131716 | All targets in OG5_131716 |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Brugia malayi | MH2 domain containing protein | SMAD family member 2 | 467 aa | 405 aa | 31.6 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | MH2 domain containing protein | 0.0144 | 0.0758 | 0.4531 |
Echinococcus granulosus | cytochrome B | 0.0502 | 0.2775 | 1 |
Plasmodium vivax | cytochrome b | 0.0502 | 0.2775 | 0.5 |
Schistosoma mansoni | cytochrome b | 0.0306 | 0.1674 | 0.603 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0144 | 0.0758 | 0.4531 |
Mycobacterium ulcerans | ubiquinol-cytochrome C reductase QcrB | 0.1782 | 1 | 0.5 |
Toxoplasma gondii | cytochrome b | 0.0502 | 0.2775 | 1 |
Echinococcus multilocularis | atpase aaa+ type core atpase aaa type core | 0.0979 | 0.5471 | 1 |
Wolbachia endosymbiont of Brugia malayi | cytochrome b subunit of the bc complex | 0.0502 | 0.2775 | 0.5 |
Brugia malayi | cytochrome b | 0.0306 | 0.1674 | 1 |
Mycobacterium tuberculosis | Probable ubiquinol-cytochrome C reductase QcrB (cytochrome B subunit) | 0.1782 | 1 | 0.5 |
Onchocerca volvulus | 0.1782 | 1 | 0.5 | |
Schistosoma mansoni | cytochrome b | 0.0502 | 0.2775 | 1 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0144 | 0.0758 | 0.4531 |
Toxoplasma gondii | apocytochrome b, putative | 0.0502 | 0.2775 | 1 |
Loa Loa (eye worm) | cytochrome b | 0.0306 | 0.1674 | 1 |
Plasmodium falciparum | cytochrome b | 0.0502 | 0.2775 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 4.609 uM | PUBCHEM_BIOASSAY: qHTS screen for small molecules that inhibit ELG1-dependent DNA repair in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493107, AID493125] | ChEMBL. | No reference |
Potency (functional) | 7.0795 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588856, AID588860] | ChEMBL. | No reference |
Potency (functional) | 89.1251 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.