Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | glucagon-like peptide 1 receptor | Starlite/ChEMBL | No references |
Homo sapiens | geminin, DNA replication inhibitor | Starlite/ChEMBL | No references |
Homo sapiens | SMAD family member 2 | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Loa Loa (eye worm) | transcription factor SMAD2 | Get druggable targets OG5_131716 | All targets in OG5_131716 |
Loa Loa (eye worm) | MH2 domain-containing protein | Get druggable targets OG5_131716 | All targets in OG5_131716 |
Brugia malayi | MH2 domain containing protein | Get druggable targets OG5_131716 | All targets in OG5_131716 |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Brugia malayi | Hypothetical 65.5 kDa Trp-Asp repeats containing protein F02E8.5 inchromosome X | geminin, DNA replication inhibitor | 209 aa | 176 aa | 27.8 % |
Brugia malayi | MH2 domain containing protein | SMAD family member 2 | 467 aa | 405 aa | 31.6 % |
Loa Loa (eye worm) | pigment dispersing factor receptor c | glucagon-like peptide 1 receptor | 463 aa | 388 aa | 25.8 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Entamoeba histolytica | hypothetical protein | 0.0043 | 0.001 | 0.5 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0043 | 0.001 | 0.014 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.006 | 0.0086 | 0.0119 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.006 | 0.0086 | 0.0119 |
Entamoeba histolytica | hypothetical protein | 0.0043 | 0.001 | 0.5 |
Brugia malayi | MH2 domain containing protein | 0.0144 | 0.0466 | 0.0646 |
Schistosoma mansoni | hypothetical protein | 0.0205 | 0.0739 | 1 |
Toxoplasma gondii | RNA-directed DNA polymerase | 0.0615 | 0.2596 | 0.5 |
Entamoeba histolytica | hypothetical protein | 0.0043 | 0.001 | 0.5 |
Leishmania major | telomerase reverse transcriptase, putative | 0.0615 | 0.2596 | 0.5 |
Brugia malayi | hypothetical protein | 0.0043 | 0.001 | 0.0014 |
Loa Loa (eye worm) | hypothetical protein | 0.006 | 0.0086 | 0.1849 |
Brugia malayi | Telomerase reverse transcriptase | 0.1637 | 0.7218 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0205 | 0.0739 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0043 | 0.001 | 0.5 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0144 | 0.0466 | 1 |
Trypanosoma cruzi | telomerase reverse transcriptase, putative | 0.0615 | 0.2596 | 0.5 |
Plasmodium vivax | telomerase reverse transcriptase, putative | 0.0615 | 0.2596 | 0.5 |
Plasmodium falciparum | telomerase reverse transcriptase | 0.0615 | 0.2596 | 0.5 |
Trypanosoma brucei | telomerase reverse transcriptase | 0.0615 | 0.2596 | 0.5 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0144 | 0.0466 | 1 |
Giardia lamblia | Telomerase catalytic subunit | 0.0615 | 0.2596 | 0.5 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.006 | 0.0086 | 0.1849 |
Trypanosoma cruzi | telomerase reverse transcriptase, putative | 0.0615 | 0.2596 | 0.5 |
Echinococcus granulosus | geminin | 0.0205 | 0.0739 | 1 |
Echinococcus multilocularis | geminin | 0.0205 | 0.0739 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0043 | 0.001 | 0.014 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 10 uM | PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 12.5893 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588856, AID588860] | ChEMBL. | No reference |
Potency (functional) | 14.581 uM | PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in SW480 colon adenocarcinoma cells. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 25.1189 uM | PubChem BioAssay. qHTS for Inhibitors of ATXN expression. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 29.081 uM | PUBCHEM_BIOASSAY: qHTS screen for small molecules that inhibit ELG1-dependent DNA repair in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493107, AID493125] | ChEMBL. | No reference |
Potency (functional) | 29.0929 uM | PUBCHEM_BIOASSAY: Nrf2 qHTS screen for inhibitors. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493153, AID493163, AID504648] | ChEMBL. | No reference |
Potency (functional) | 29.0929 uM | PubChem BioAssay. qHTS for induction of synthetic lethality in tumor cells producing 2HG: qHTS for the HT-1080-NT fibrosarcoma cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.