Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | expressed protein | 0.0367 | 0.4781 | 0.2127 |
Echinococcus granulosus | expressed protein | 0.0367 | 0.4781 | 0.2127 |
Loa Loa (eye worm) | ryanodine receptor | 0.0106 | 0.0402 | 0.1193 |
Schistosoma mansoni | ryanodine receptor related | 0.0448 | 0.6135 | 0.5939 |
Brugia malayi | Ryanodine Receptor TM 4-6 family protein | 0.0448 | 0.6135 | 1 |
Schistosoma mansoni | microtubule-associated protein tau | 0.0679 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0085 | 0.0059 | 0.0175 |
Leishmania major | hypothetical protein, conserved | 0.011 | 0.047 | 0.5 |
Echinococcus multilocularis | microtubule associated protein 2 | 0.0679 | 1 | 1 |
Echinococcus multilocularis | ryanodine receptor 44f | 0.0363 | 0.4707 | 0.2016 |
Trypanosoma brucei | inositol 1,4,5-trisphosphate receptor | 0.0162 | 0.1337 | 0.5 |
Trypanosoma cruzi | inositol 1,4,5-trisphosphate receptor, putative | 0.0162 | 0.1337 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0283 | 0.337 | 1 |
Loa Loa (eye worm) | ryanodine receptor | 0.0167 | 0.1434 | 0.4255 |
Schistosoma mansoni | inositol 145-trisphosphate receptor | 0.0137 | 0.0925 | 0.0466 |
Echinococcus granulosus | ryanodine receptor 44f | 0.0363 | 0.4707 | 0.2016 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | Inhibition of Plasmodium falciparum falcipain 3 incubated with compound for 10 mins before addition of 25 uM Z-Leu-Arg-AMC substrate by fluorescence spectrophotometry | ChEMBL. | 21295887 | |
IC50 (binding) | > 50 uM | Inhibition of Plasmodium falciparum falcipain 2 incubated with compound for 10 mins before addition of 25 uM Z-Leu-Arg-AMC substrate by fluorescence spectrophotometry | ChEMBL. | 21295887 |
IC50 (functional) | > 50 uM | Antiplasmodial activity against chloroquine-resistant Plasmodium falciparum W2 infected in human red blood cells assessed as inhibition of ring-stage parasite growth after 48 hrs by flow cytometry | ChEMBL. | 21295887 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.