Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | phosphodiesterase 3B, cGMP-inhibited | References | |
Homo sapiens | phosphodiesterase 3A, cGMP-inhibited | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Brugia malayi | 3'5'-cyclic nucleotide phosphodiesterase family protein | Get druggable targets OG5_132613 | All targets in OG5_132613 |
Loa Loa (eye worm) | hypothetical protein | Get druggable targets OG5_132613 | All targets in OG5_132613 |
Loa Loa (eye worm) | hypothetical protein | Get druggable targets OG5_132613 | All targets in OG5_132613 |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trichomonas vaginalis | conserved hypothetical protein | 0.0179 | 0.0279 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0179 | 0.0279 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0179 | 0.0279 | 1 |
Giardia lamblia | NADPH oxidoreductase, putative | 0.0179 | 0.0279 | 0.5 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0179 | 0.0279 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0179 | 0.0279 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0179 | 0.0279 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0179 | 0.0279 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0179 | 0.0279 | 1 |
Trichomonas vaginalis | NAD(P)H dehydrogenase, putative | 0.0179 | 0.0279 | 1 |
Brugia malayi | 3'5'-cyclic nucleotide phosphodiesterase family protein | 0.1027 | 0.5596 | 0.5 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0179 | 0.0279 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0179 | 0.0279 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.1027 | 0.5596 | 1 |
Giardia lamblia | NADPH oxidoreductase, putative | 0.0179 | 0.0279 | 0.5 |
Trichomonas vaginalis | NAD(P)H dehydrogenase, putative | 0.0179 | 0.0279 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0179 | 0.0279 | 1 |
Giardia lamblia | NADPH oxidoreductase, putative | 0.0179 | 0.0279 | 0.5 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0179 | 0.0279 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0179 | 0.0279 | 1 |
Mycobacterium tuberculosis | Probable UDP-N-acetylglucosamine pyrophosphorylase GlmU | 0.173 | 1 | 1 |
Trichomonas vaginalis | NAD(P)H dehydrogenase, putative | 0.0179 | 0.0279 | 1 |
Toxoplasma gondii | eukaryotic initiation factor-2B, gamma subunit, putative | 0.0317 | 0.1149 | 0.5 |
Mycobacterium ulcerans | bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase | 0.173 | 1 | 1 |
Wolbachia endosymbiont of Brugia malayi | N-acetylglucosamine-1-phosphate uridyltransferase | 0.173 | 1 | 0.5 |
Treponema pallidum | licC protein (licC) | 0.0317 | 0.1149 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
EC50 (functional) | = 0.054 uM | Inhibition of ADP-induced aggregation of human platelets | ChEMBL. | 1321911 |
EC50 (functional) | = 0.054 uM | Inhibition of ADP-induced aggregation of human platelets | ChEMBL. | 1321911 |
IC50 (binding) | = 0.2 nM | Inhibition of human platelet c-AMP phosphodiesterase PDE 3 | ChEMBL. | 1321911 |
IC50 (binding) | = 0.2 nM | Inhibition of human platelet c-AMP phosphodiesterase PDE 3 | ChEMBL. | 1321911 |
S | < 10 mg ml-1 | Aqueous solubility | ChEMBL. | 1321911 |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Homo sapiens | ChEMBL23 | 1321911 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.