Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | ATPase family, AAA domain containing 5 | Starlite/ChEMBL | No references |
Homo sapiens | nuclear factor, erythroid 2-like 2 | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Echinococcus multilocularis | atpase aaa+ type core atpase aaa type core | Get druggable targets OG5_139225 | All targets in OG5_139225 |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0087 | 0.0314 | 0.1189 |
Trypanosoma cruzi | inositol 1,4,5-trisphosphate receptor, putative | 0.0172 | 0.1238 | 0.5 |
Schistosoma mansoni | ryanodine receptor related | 0.0478 | 0.4554 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0118 | 0.0647 | 0.1421 |
Loa Loa (eye worm) | hypothetical protein | 0.0091 | 0.0355 | 0.1344 |
Loa Loa (eye worm) | hypothetical protein | 0.0302 | 0.2643 | 1 |
Trypanosoma brucei | inositol 1,4,5-trisphosphate receptor | 0.0172 | 0.1238 | 0.5 |
Loa Loa (eye worm) | ryanodine receptor | 0.0113 | 0.0592 | 0.224 |
Echinococcus granulosus | ryanodine receptor 44f | 0.0387 | 0.3567 | 1 |
Loa Loa (eye worm) | ryanodine receptor | 0.0178 | 0.1305 | 0.4938 |
Schistosoma mansoni | inositol 145-trisphosphate receptor | 0.0146 | 0.0954 | 0.2094 |
Echinococcus multilocularis | ryanodine receptor 44f | 0.0387 | 0.3567 | 0.1255 |
Leishmania major | hypothetical protein, conserved | 0.0117 | 0.0639 | 0.5 |
Brugia malayi | Ryanodine Receptor TM 4-6 family protein | 0.0478 | 0.4554 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 11.5774 uM | PUBCHEM_BIOASSAY: qHTS screen for small molecules that inhibit ELG1-dependent DNA repair in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493107, AID493125] | ChEMBL. | No reference |
Potency (functional) | 16.3601 uM | PUBCHEM_BIOASSAY: Nrf2 qHTS screen for inhibitors. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493153, AID493163, AID504648] | ChEMBL. | No reference |
Potency (functional) | 22.3872 uM | PubChem BioAssay. qHTS for Antagonist of cAMP-regulated guanine nucleotide exchange factor 2 (EPAC2): primary screen. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 23.1093 uM | PubChem BioAssay. qHTS for induction of synthetic lethality in tumor cells producing 2HG: qHTS for the HT-1080-NT fibrosarcoma cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 25.1189 uM | PubChem BioAssay. qHTS for Inhibitors of ATXN expression. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 28.1838 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] | ChEMBL. | No reference |
Potency (functional) | 50.1187 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Eta. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588636] | ChEMBL. | No reference |
Potency (functional) | 50.1187 uM | PubChem BioAssay. qHTS for Antagonist of cAMP-regulated guanine nucleotide exchange factor 3 (EPAC1): primary screen. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 75.6863 uM | PubChem BioAssay. qHTS Assay to Find Inhibitors of Pin1. (Class of assay: confirmatory) | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.