Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Human immunodeficiency virus 1 | Reverse transcriptase | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Trypanosoma congolense | RNA helicase, putative | Get druggable targets OG5_139608 | All targets in OG5_139608 |
Plasmodium yoelii | integrase-related | Get druggable targets OG5_139608 | All targets in OG5_139608 |
Schistosoma mansoni | hypothetical protein | Get druggable targets OG5_139608 | All targets in OG5_139608 |
Trypanosoma brucei | RNA helicase, putative | Get druggable targets OG5_139608 | All targets in OG5_139608 |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | glutamate receptor ionotropic kainate 3 | 0.0262 | 0.4822 | 0.4822 |
Echinococcus granulosus | Glutamate receptor ionotropic kainate 2 | 0.0415 | 1 | 1 |
Echinococcus granulosus | glutamate receptor ionotropic kainate | 0.0262 | 0.4822 | 0.4822 |
Echinococcus multilocularis | glutamate receptor ionotropic kainate | 0.0262 | 0.4822 | 0.4822 |
Schistosoma mansoni | glutamate receptor NMDA | 0.0187 | 0.227 | 0.0941 |
Schistosoma mansoni | glutamate receptor AMPA | 0.0187 | 0.227 | 0.0941 |
Echinococcus multilocularis | glutamate receptor, ionotrophic, AMPA 3 | 0.0273 | 0.5178 | 0.5178 |
Echinococcus granulosus | glutamate receptor ionotrophic AMPA 3 | 0.0273 | 0.5178 | 0.5178 |
Echinococcus multilocularis | glutamate receptor 2 | 0.0204 | 0.284 | 0.284 |
Brugia malayi | Glutamate receptor 2 precursor | 0.0237 | 0.398 | 0.5 |
Echinococcus granulosus | glutamate receptor 2 | 0.0273 | 0.5178 | 0.5178 |
Echinococcus multilocularis | Glutamate receptor, ionotropic kainate 3 | 0.0262 | 0.4822 | 0.4822 |
Schistosoma mansoni | glutamate receptor NMDA | 0.0222 | 0.3469 | 0.2604 |
Echinococcus multilocularis | Glutamate receptor, ionotropic kainate 2 | 0.0415 | 1 | 1 |
Schistosoma mansoni | glutamate receptor kainate | 0.038 | 0.8801 | 1 |
Schistosoma mansoni | glutamate receptor AMPA | 0.0187 | 0.227 | 0.0941 |
Echinococcus granulosus | glutamate NMDA receptor subunit | 0.0187 | 0.227 | 0.227 |
Echinococcus multilocularis | Glutamate receptor, ionotropic kainate 2 | 0.0415 | 1 | 1 |
Echinococcus multilocularis | glutamate (NMDA) receptor subunit | 0.0187 | 0.227 | 0.227 |
Echinococcus multilocularis | glutamate receptor 2 | 0.0273 | 0.5178 | 0.5178 |
Trypanosoma brucei | RNA helicase, putative | 0.0167 | 0.1592 | 0.5 |
Loa Loa (eye worm) | glutamate receptor 1 | 0.0237 | 0.398 | 1 |
Echinococcus multilocularis | Glutamate receptor, ionotropic kainate 2 | 0.0415 | 1 | 1 |
Echinococcus granulosus | glutamate receptor 2 | 0.0204 | 0.284 | 0.284 |
Schistosoma mansoni | ATP-binding cassette transporter | 0.0187 | 0.227 | 0.0941 |
Echinococcus multilocularis | glutamate receptor 2 | 0.0237 | 0.398 | 0.398 |
Schistosoma mansoni | glutamate receptor kainate | 0.038 | 0.8801 | 1 |
Echinococcus multilocularis | NMDA receptor | 0.0262 | 0.4822 | 0.4822 |
Echinococcus granulosus | Glutamate receptor ionotropic kainate 2 | 0.0415 | 1 | 1 |
Schistosoma mansoni | glutamate receptor kainate | 0.0187 | 0.227 | 0.0941 |
Brugia malayi | Glutamate receptor 1 precursor | 0.0237 | 0.398 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 80 nM | Inhibition of Human immunodeficiency virus 1 reverse transcriptase | ChEMBL. | 21272964 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.