Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | glucagon-like peptide 1 receptor | Starlite/ChEMBL | No references |
Homo sapiens | GNAS complex locus | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Loa Loa (eye worm) | pigment dispersing factor receptor c | glucagon-like peptide 1 receptor | 463 aa | 388 aa | 25.8 % |
Schistosoma mansoni | GTP-binding protein alpha subunit gna | GNAS complex locus | 394 aa | 450 aa | 28.7 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0055 | 0.1021 | 0.1066 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0041 | 0.0717 | 0.3056 |
Plasmodium falciparum | peptide deformylase | 0.0471 | 1 | 1 |
Entamoeba histolytica | exodeoxyribonuclease III, putative | 0.0018 | 0.0225 | 0.5 |
Loa Loa (eye worm) | exodeoxyribonuclease III family protein | 0.0018 | 0.0225 | 0.0959 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0117 | 0.2346 | 1 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0055 | 0.1021 | 1 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0117 | 0.2346 | 1 |
Loa Loa (eye worm) | latrophilin receptor protein 2 | 0.0019 | 0.024 | 0.1022 |
Brugia malayi | Latrophilin receptor protein 2 | 0.0019 | 0.024 | 0.1022 |
Toxoplasma gondii | hypothetical protein | 0.0471 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0019 | 0.024 | 0.1022 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0055 | 0.1021 | 0.1066 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.006 | 0.1128 | 0.4809 |
Schistosoma mansoni | ap endonuclease | 0.0018 | 0.0225 | 0.2204 |
Plasmodium vivax | peptide deformylase, putative | 0.0471 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0041 | 0.0717 | 0.3056 |
Schistosoma mansoni | hypothetical protein | 0.0019 | 0.024 | 0.2348 |
Schistosoma mansoni | hypothetical protein | 0.0019 | 0.024 | 0.2348 |
Schistosoma mansoni | hypothetical protein | 0.0041 | 0.0717 | 0.7022 |
Trypanosoma brucei | Peptide deformylase 2 | 0.018 | 0.371 | 1 |
Echinococcus multilocularis | neuropeptide receptor A26 | 0.0452 | 0.9578 | 1 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.006 | 0.1128 | 0.4809 |
Echinococcus granulosus | GPCR family 2 | 0.0019 | 0.024 | 0.025 |
Trypanosoma cruzi | polypeptide deformylase-like protein, putative | 0.018 | 0.371 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0019 | 0.024 | 0.2348 |
Echinococcus granulosus | neuropeptide receptor A26 | 0.0452 | 0.9578 | 1 |
Trypanosoma cruzi | Peptide deformylase 2, putative | 0.018 | 0.371 | 1 |
Echinococcus granulosus | DNA apurinic or apyrimidinic site lyase | 0.0018 | 0.0225 | 0.0235 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0055 | 0.1021 | 0.4352 |
Echinococcus multilocularis | cadherin EGF LAG seven pass G type receptor | 0.0019 | 0.024 | 0.025 |
Leishmania major | polypeptide deformylase-like protein, putative | 0.018 | 0.371 | 1 |
Trichomonas vaginalis | ap endonuclease, putative | 0.0018 | 0.0225 | 0.5 |
Trichomonas vaginalis | ap endonuclease, putative | 0.0018 | 0.0225 | 0.5 |
Wolbachia endosymbiont of Brugia malayi | peptide deformylase | 0.0471 | 1 | 1 |
Mycobacterium ulcerans | peptide deformylase | 0.0471 | 1 | 1 |
Echinococcus multilocularis | DNA (apurinic or apyrimidinic site) lyase | 0.0018 | 0.0225 | 0.0235 |
Mycobacterium tuberculosis | Probable polypeptide deformylase Def (PDF) (formylmethionine deformylase) | 0.0471 | 1 | 1 |
Mycobacterium leprae | PROBABLE POLYPEPTIDE DEFORMYLASE DEF (PDF) (FORMYLMETHIONINE DEFORMYLASE) | 0.0471 | 1 | 0.5 |
Echinococcus multilocularis | neuropeptide s receptor | 0.0452 | 0.9578 | 1 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0055 | 0.1021 | 1 |
Brugia malayi | exodeoxyribonuclease III family protein | 0.0018 | 0.0225 | 0.0959 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0055 | 0.1021 | 0.1066 |
Echinococcus granulosus | cadherin EGF LAG seven pass G type receptor | 0.0019 | 0.024 | 0.025 |
Giardia lamblia | Endonuclease/Exonuclease/phosphatase | 0.0018 | 0.0225 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.006 | 0.1128 | 0.4809 |
Treponema pallidum | polypeptide deformylase (def) | 0.0471 | 1 | 1 |
Brugia malayi | calcium-independent alpha-latrotoxin receptor 2, putative | 0.0019 | 0.024 | 0.1022 |
Trypanosoma cruzi | polypeptide deformylase-like protein, putative | 0.018 | 0.371 | 1 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0055 | 0.1021 | 0.4352 |
Schistosoma mansoni | hypothetical protein | 0.0019 | 0.024 | 0.2348 |
Trypanosoma brucei | Polypeptide deformylase 1 | 0.018 | 0.371 | 1 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.006 | 0.1128 | 0.4809 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0055 | 0.1021 | 0.1066 |
Echinococcus granulosus | neuropeptide s receptor | 0.0452 | 0.9578 | 1 |
Echinococcus multilocularis | GPCR, family 2 | 0.0019 | 0.024 | 0.025 |
Schistosoma mansoni | ap endonuclease | 0.0018 | 0.0225 | 0.2204 |
Trypanosoma cruzi | Peptide deformylase 2, putative | 0.018 | 0.371 | 1 |
Echinococcus multilocularis | diuretic hormone 44 receptor GPRdih2 | 0.0019 | 0.024 | 0.025 |
Brugia malayi | MH2 domain containing protein | 0.0117 | 0.2346 | 1 |
Echinococcus granulosus | diuretic hormone 44 receptor GPRdih2 | 0.0019 | 0.024 | 0.025 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0055 | 0.1021 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 4.4668 uM | PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 11.2202 uM | PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 18.526 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Potency (functional) | 25.929 uM | PUBCHEM_BIOASSAY: Nrf2 qHTS screen for inhibitors. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493153, AID493163, AID504648] | ChEMBL. | No reference |
Potency (functional) | 39.8107 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] | ChEMBL. | No reference |
Potency (functional) | 79.4328 uM | PubChem BioAssay. qHTS for Antagonist of cAMP-regulated guanine nucleotide exchange factor 3 (EPAC1): primary screen. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 89.1251 uM | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504404] | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Plasmodium falciparum | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.