Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | ubiquitin specific peptidase 1 | Starlite/ChEMBL | No references |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0286 | 0.0584 | 0.5 |
Echinococcus granulosus | lysine specific histone demethylase 1A | 0.0286 | 0.0584 | 0.0681 |
Loa Loa (eye worm) | hypothetical protein | 0.0286 | 0.0584 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0286 | 0.0584 | 0.5 |
Toxoplasma gondii | histone lysine-specific demethylase LSD1/BHC110/KDMA1A | 0.0286 | 0.0584 | 0.5 |
Echinococcus granulosus | lysine specific histone demethylase 1A | 0.0286 | 0.0584 | 0.0681 |
Schistosoma mansoni | Protoporphyrinogen oxidase chloroplast/mitochondrial precursor | 0.2172 | 1 | 1 |
Mycobacterium ulcerans | protoporphyrinogen oxidase | 0.2172 | 1 | 1 |
Mycobacterium tuberculosis | Probable protoporphyrinogen oxidase HemY (protoporphyrinogen-IX oxidase) (protoporphyrinogenase) (PPO) | 0.1886 | 0.8573 | 1 |
Plasmodium vivax | protoporphyrinogen oxidase, putative | 0.0286 | 0.0584 | 0.5 |
Mycobacterium leprae | PROBABLE PROTOPORPHYRINOGEN OXIDASE HEMY (PROTOPORPHYRINOGEN-IX OXIDASE) (PROTOPORPHYRINOGENASE) (PPO) | 0.2172 | 1 | 0.5 |
Echinococcus multilocularis | protoporphyrinogen oxidase | 0.2172 | 1 | 1 |
Trypanosoma cruzi | UDP-galactopyranose mutase | 0.0286 | 0.0584 | 0.5 |
Onchocerca volvulus | 0.0286 | 0.0584 | 0.5 | |
Plasmodium falciparum | lysine-specific histone demethylase 1, putative | 0.0286 | 0.0584 | 0.5 |
Brugia malayi | amine oxidase, flavin-containing family protein | 0.0286 | 0.0584 | 0.5 |
Plasmodium falciparum | protoporphyrinogen oxidase | 0.0286 | 0.0584 | 0.5 |
Echinococcus granulosus | protoporphyrinogen oxidase | 0.1886 | 0.8573 | 1 |
Leishmania major | UDP-galactopyranose mutase | 0.0286 | 0.0584 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0286 | 0.0584 | 0.5 |
Toxoplasma gondii | histone lysine-specific demethylase | 0.0286 | 0.0584 | 0.5 |
Plasmodium vivax | hypothetical protein, conserved | 0.0286 | 0.0584 | 0.5 |
Brugia malayi | hypothetical protein | 0.0286 | 0.0584 | 0.5 |
Plasmodium falciparum | conserved Plasmodium protein, unknown function | 0.0286 | 0.0584 | 0.5 |
Schistosoma mansoni | Lysine-specific histone demethylase 1 | 0.0286 | 0.0584 | 0.0584 |
Plasmodium vivax | lysine-specific histone demethylase 1, putative | 0.0286 | 0.0584 | 0.5 |
Schistosoma mansoni | amine oxidase | 0.0286 | 0.0584 | 0.0584 |
Loa Loa (eye worm) | hypothetical protein | 0.0286 | 0.0584 | 0.5 |
Schistosoma mansoni | amine oxidase | 0.0286 | 0.0584 | 0.0584 |
Plasmodium vivax | hypothetical protein, conserved | 0.0286 | 0.0584 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0286 | 0.0584 | 0.5 |
Trypanosoma cruzi | UDP-galactopyranose mutase | 0.0286 | 0.0584 | 0.5 |
Echinococcus multilocularis | 0.0286 | 0.0584 | 0.0584 | |
Echinococcus multilocularis | lysine specific histone demethylase 1A | 0.0286 | 0.0584 | 0.0584 |
Brugia malayi | SWIRM domain containing protein | 0.0286 | 0.0584 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 0.1 uM | PubChem BioAssay. Inhibitors of USP1/UAF1: Primary Screen. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 25.1189 uM | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Mammalian Selenoprotein Thioredoxin Reductase 1 (TrxR1): qHTS. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488771] | ChEMBL. | No reference |
Potency (functional) | 25.1189 uM | PubChem BioAssay. qHTS Assay for Activators of ClpP. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 32.6427 uM | PUBCHEM_BIOASSAY: Nrf2 qHTS screen for inhibitors. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493153, AID493163, AID504648] | ChEMBL. | No reference |
Potency (functional) | 44.6684 uM | PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] | ChEMBL. | No reference |
Potency (functional) | 70.7946 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of mutant isocitrate dehydrogenase 1 (IDH1): qHTS. (Class of assay: confirmatory) | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.