Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | euchromatic histone-lysine N-methyltransferase 2 | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Trichomonas vaginalis | set domain proteins, putative | Get druggable targets OG5_131470 | All targets in OG5_131470 |
Loa Loa (eye worm) | pre-SET domain-containing protein family protein | Get druggable targets OG5_131470 | All targets in OG5_131470 |
Onchocerca volvulus | Get druggable targets OG5_131470 | All targets in OG5_131470 | |
Brugia malayi | Pre-SET motif family protein | Get druggable targets OG5_131470 | All targets in OG5_131470 |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma cruzi | inositol 1,4,5-trisphosphate receptor, putative | 0.0174 | 0.2771 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0119 | 0.1483 | 0.1483 |
Brugia malayi | Pre-SET motif family protein | 0.0251 | 0.4587 | 0.1636 |
Loa Loa (eye worm) | ryanodine receptor | 0.018 | 0.2918 | 0.4938 |
Trypanosoma brucei | inositol 1,4,5-trisphosphate receptor | 0.0174 | 0.2771 | 0.5 |
Loa Loa (eye worm) | pre-SET domain-containing protein family protein | 0.0251 | 0.4587 | 0.7835 |
Schistosoma mansoni | inositol 145-trisphosphate receptor | 0.0147 | 0.2151 | 0.2151 |
Schistosoma mansoni | ryanodine receptor related | 0.0482 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0088 | 0.0757 | 0.1189 |
Leishmania major | hypothetical protein, conserved | 0.0118 | 0.1466 | 0.5 |
Echinococcus granulosus | ryanodine receptor 44f | 0.039 | 0.7849 | 1 |
Echinococcus multilocularis | ryanodine receptor 44f | 0.039 | 0.7849 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0092 | 0.0846 | 0.1344 |
Trichomonas vaginalis | set domain proteins, putative | 0.0286 | 0.5401 | 0.5 |
Loa Loa (eye worm) | ryanodine receptor | 0.0114 | 0.1363 | 0.224 |
Schistosoma mansoni | inositol 145-trisphosphate receptor | 0.0059 | 0.0072 | 0.0072 |
Onchocerca volvulus | 0.0286 | 0.5401 | 0.5 | |
Loa Loa (eye worm) | hypothetical protein | 0.0305 | 0.5835 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 6.3096 uM | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504404] | ChEMBL. | No reference |
Potency (functional) | 10.4179 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Potency (functional) | 18.526 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Potency (functional) | 35.4813 uM | PUBCHEM_BIOASSAY: qHTS assay for re-activators of p53 using a Luc reporter. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504709] | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Plasmodium falciparum | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.