Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | euchromatic histone-lysine N-methyltransferase 2 | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Brugia malayi | Pre-SET motif family protein | Get druggable targets OG5_131470 | All targets in OG5_131470 |
Trichomonas vaginalis | set domain proteins, putative | Get druggable targets OG5_131470 | All targets in OG5_131470 |
Loa Loa (eye worm) | pre-SET domain-containing protein family protein | Get druggable targets OG5_131470 | All targets in OG5_131470 |
Onchocerca volvulus | Get druggable targets OG5_131470 | All targets in OG5_131470 |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Plasmodium vivax | lysine-specific histone demethylase 1, putative | 0.0111 | 0.0929 | 1 |
Plasmodium vivax | hypothetical protein, conserved | 0.0111 | 0.0929 | 1 |
Plasmodium vivax | protoporphyrinogen oxidase, putative | 0.0111 | 0.0929 | 1 |
Toxoplasma gondii | histone lysine-specific demethylase LSD1/BHC110/KDMA1A | 0.0111 | 0.0929 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0111 | 0.0929 | 0.3487 |
Plasmodium falciparum | lysine-specific histone demethylase 1, putative | 0.0111 | 0.0929 | 0.5 |
Onchocerca volvulus | 0.0286 | 0.3092 | 1 | |
Onchocerca volvulus | 0.0111 | 0.0929 | 0.3003 | |
Leishmania major | UDP-galactopyranose mutase | 0.0111 | 0.0929 | 0.5 |
Trypanosoma cruzi | UDP-galactopyranose mutase | 0.0111 | 0.0929 | 0.5 |
Loa Loa (eye worm) | pre-SET domain-containing protein family protein | 0.0251 | 0.2663 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0111 | 0.0929 | 0.3487 |
Echinococcus multilocularis | lysine specific histone demethylase 1A | 0.0111 | 0.0929 | 0.0929 |
Brugia malayi | amine oxidase, flavin-containing family protein | 0.0111 | 0.0929 | 0.3487 |
Brugia malayi | hypothetical protein | 0.0111 | 0.0929 | 0.3487 |
Schistosoma mansoni | Lysine-specific histone demethylase 1 | 0.0111 | 0.0929 | 0.0929 |
Mycobacterium leprae | PROBABLE PROTOPORPHYRINOGEN OXIDASE HEMY (PROTOPORPHYRINOGEN-IX OXIDASE) (PROTOPORPHYRINOGENASE) (PPO) | 0.0845 | 1 | 0.5 |
Echinococcus multilocularis | protoporphyrinogen oxidase | 0.0845 | 1 | 1 |
Plasmodium falciparum | conserved Plasmodium protein, unknown function | 0.0111 | 0.0929 | 0.5 |
Plasmodium falciparum | protoporphyrinogen oxidase | 0.0111 | 0.0929 | 0.5 |
Plasmodium vivax | hypothetical protein, conserved | 0.0111 | 0.0929 | 1 |
Echinococcus granulosus | lysine specific histone demethylase 1A | 0.0111 | 0.0929 | 0.1077 |
Echinococcus multilocularis | 0.0111 | 0.0929 | 0.0929 | |
Trypanosoma cruzi | UDP-galactopyranose mutase | 0.0111 | 0.0929 | 0.5 |
Schistosoma mansoni | amine oxidase | 0.0111 | 0.0929 | 0.0929 |
Echinococcus granulosus | protoporphyrinogen oxidase | 0.0733 | 0.8626 | 1 |
Toxoplasma gondii | histone lysine-specific demethylase | 0.0111 | 0.0929 | 1 |
Echinococcus granulosus | lysine specific histone demethylase 1A | 0.0111 | 0.0929 | 0.1077 |
Loa Loa (eye worm) | hypothetical protein | 0.0111 | 0.0929 | 0.3487 |
Schistosoma mansoni | amine oxidase | 0.0111 | 0.0929 | 0.0929 |
Loa Loa (eye worm) | hypothetical protein | 0.0111 | 0.0929 | 0.3487 |
Loa Loa (eye worm) | hypothetical protein | 0.0111 | 0.0929 | 0.3487 |
Brugia malayi | Pre-SET motif family protein | 0.0251 | 0.2663 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0111 | 0.0929 | 0.3487 |
Brugia malayi | SWIRM domain containing protein | 0.0111 | 0.0929 | 0.3487 |
Trichomonas vaginalis | set domain proteins, putative | 0.0286 | 0.3092 | 0.5 |
Schistosoma mansoni | Protoporphyrinogen oxidase chloroplast/mitochondrial precursor | 0.0845 | 1 | 1 |
Mycobacterium ulcerans | protoporphyrinogen oxidase | 0.0845 | 1 | 1 |
Mycobacterium tuberculosis | Probable protoporphyrinogen oxidase HemY (protoporphyrinogen-IX oxidase) (protoporphyrinogenase) (PPO) | 0.0733 | 0.8626 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 7.0795 uM | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504404] | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.