Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | MDM2 proto-oncogene, E3 ubiquitin protein ligase | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Toxoplasma gondii | histone lysine-specific demethylase LSD1/BHC110/KDMA1A | 0.0341 | 0.1272 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0341 | 0.1272 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0341 | 0.1272 | 1 |
Echinococcus granulosus | lysine specific histone demethylase 1A | 0.0341 | 0.1272 | 0.1466 |
Loa Loa (eye worm) | hypothetical protein | 0.0341 | 0.1272 | 1 |
Mycobacterium ulcerans | protoporphyrinogen oxidase | 0.2588 | 1 | 1 |
Mycobacterium tuberculosis | Probable protoporphyrinogen oxidase HemY (protoporphyrinogen-IX oxidase) (protoporphyrinogenase) (PPO) | 0.2247 | 0.8678 | 1 |
Schistosoma mansoni | Protoporphyrinogen oxidase chloroplast/mitochondrial precursor | 0.2588 | 1 | 1 |
Echinococcus granulosus | lysine specific histone demethylase 1A | 0.0341 | 0.1272 | 0.1466 |
Plasmodium falciparum | lysine-specific histone demethylase 1, putative | 0.0341 | 0.1272 | 1 |
Plasmodium falciparum | protoporphyrinogen oxidase | 0.0341 | 0.1272 | 1 |
Brugia malayi | amine oxidase, flavin-containing family protein | 0.0341 | 0.1272 | 1 |
Onchocerca volvulus | 0.0341 | 0.1272 | 1 | |
Trypanosoma cruzi | UDP-galactopyranose mutase | 0.0341 | 0.1272 | 0.5 |
Echinococcus multilocularis | protoporphyrinogen oxidase | 0.2588 | 1 | 1 |
Mycobacterium leprae | PROBABLE PROTOPORPHYRINOGEN OXIDASE HEMY (PROTOPORPHYRINOGEN-IX OXIDASE) (PROTOPORPHYRINOGENASE) (PPO) | 0.2588 | 1 | 0.5 |
Plasmodium vivax | protoporphyrinogen oxidase, putative | 0.0341 | 0.1272 | 1 |
Toxoplasma gondii | histone lysine-specific demethylase | 0.0341 | 0.1272 | 1 |
Leishmania major | UDP-galactopyranose mutase | 0.0341 | 0.1272 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0341 | 0.1272 | 1 |
Echinococcus granulosus | protoporphyrinogen oxidase | 0.2247 | 0.8678 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0013 | 0 | 0.5 |
Plasmodium falciparum | conserved Plasmodium protein, unknown function | 0.0341 | 0.1272 | 1 |
Brugia malayi | hypothetical protein | 0.0341 | 0.1272 | 1 |
Plasmodium vivax | hypothetical protein, conserved | 0.0341 | 0.1272 | 1 |
Plasmodium vivax | lysine-specific histone demethylase 1, putative | 0.0341 | 0.1272 | 1 |
Schistosoma mansoni | Lysine-specific histone demethylase 1 | 0.0341 | 0.1272 | 0.1272 |
Schistosoma mansoni | amine oxidase | 0.0341 | 0.1272 | 0.1272 |
Loa Loa (eye worm) | hypothetical protein | 0.0341 | 0.1272 | 1 |
Schistosoma mansoni | amine oxidase | 0.0341 | 0.1272 | 0.1272 |
Brugia malayi | SWIRM domain containing protein | 0.0341 | 0.1272 | 1 |
Echinococcus multilocularis | lysine specific histone demethylase 1A | 0.0341 | 0.1272 | 0.1272 |
Echinococcus multilocularis | 0.0341 | 0.1272 | 0.1272 | |
Trypanosoma cruzi | UDP-galactopyranose mutase | 0.0341 | 0.1272 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0341 | 0.1272 | 1 |
Plasmodium vivax | hypothetical protein, conserved | 0.0341 | 0.1272 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 0.7 uM | Inhibition of Mdm2 -p53 protein interaction by ELISA | ChEMBL. | 21314128 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.