Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Mus musculus | melanocortin 3 receptor | Starlite/ChEMBL | References |
Mus musculus | melanocortin 5 receptor | Starlite/ChEMBL | References |
Mus musculus | melanocortin 1 receptor | Starlite/ChEMBL | References |
Mus musculus | melanocortin 4 receptor | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Brugia malayi | hypothetical protein | melanocortin 5 receptor | 372 aa | 314 aa | 21.0 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium ulcerans | protoporphyrinogen oxidase | 0.0481 | 1 | 0.5 |
Echinococcus multilocularis | protoporphyrinogen oxidase | 0.0481 | 1 | 0.5 |
Mycobacterium leprae | PROBABLE PROTOPORPHYRINOGEN OXIDASE HEMY (PROTOPORPHYRINOGEN-IX OXIDASE) (PROTOPORPHYRINOGENASE) (PPO) | 0.0481 | 1 | 0.5 |
Mycobacterium tuberculosis | Probable protoporphyrinogen oxidase HemY (protoporphyrinogen-IX oxidase) (protoporphyrinogenase) (PPO) | 0.0418 | 0 | 0.5 |
Echinococcus granulosus | protoporphyrinogen oxidase | 0.0418 | 0 | 0.5 |
Schistosoma mansoni | Protoporphyrinogen oxidase chloroplast/mitochondrial precursor | 0.0481 | 1 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
EC50 (binding) | = 0.17 nM | Agonist activity at mouse MC4 receptor expressed in HEK293 cells after 6 hrs by cAMP-based beta-galactosidase reporter gene assay | ChEMBL. | 23432160 |
EC50 (functional) | = 0.27 nM | Agonist activity at mouse melanocortin 4 receptor expressed in HEK293 cells after 48 hrs by cAMP based beta-galactosidase reporter gene assay | ChEMBL. | 21306168 |
EC50 (binding) | = 0.3 nM | Agonist activity at mouse MC1 receptor expressed in HEK293 cells after 6 hrs by cAMP-based beta-galactosidase reporter gene assay | ChEMBL. | 23432160 |
EC50 (functional) | = 0.35 nM | Agonist activity at mouse melanocortin 1 receptor expressed in HEK293 cells after 48 hrs by cAMP based beta-galactosidase reporter gene assay | ChEMBL. | 21306168 |
EC50 (binding) | = 1.45 nM | Agonist activity at mouse MC5 receptor expressed in HEK293 cells after 6 hrs by cAMP-based beta-galactosidase reporter gene assay | ChEMBL. | 23432160 |
EC50 (binding) | = 1.7 nM | Agonist activity at mouse MC3 receptor expressed in HEK293 cells after 6 hrs by cAMP-based beta-galactosidase reporter gene assay | ChEMBL. | 23432160 |
EC50 (functional) | = 2 nM | Agonist activity at mouse melanocortin 3 receptor expressed in HEK293 cells after 48 hrs by cAMP based beta-galactosidase reporter gene assay | ChEMBL. | 21306168 |
EC50 (functional) | = 2.3 nM | Agonist activity at mouse melanocortin 5 receptor expressed in HEK293 cells after 48 hrs by cAMP based beta-galactosidase reporter gene assay | ChEMBL. | 21306168 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
2 literature references were collected for this gene.