Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0029 | 0.032 | 0.3019 |
Plasmodium vivax | lysine-specific histone demethylase 1, putative | 0.0045 | 0.0809 | 1 |
Mycobacterium ulcerans | flavin-containing monoamine oxidase AofH | 0.0045 | 0.0809 | 0.0709 |
Trichomonas vaginalis | DNA polymerase eta, putative | 0.0023 | 0.0108 | 0.5 |
Echinococcus granulosus | lysine specific histone demethylase 1A | 0.0045 | 0.0809 | 0.0825 |
Brugia malayi | Ets-domain containing protein | 0.0085 | 0.2012 | 0.2758 |
Brugia malayi | Ets-domain containing protein | 0.0085 | 0.2012 | 0.2758 |
Loa Loa (eye worm) | hypothetical protein | 0.0045 | 0.0809 | 0.0976 |
Mycobacterium ulcerans | oxidoreductase | 0.0045 | 0.0809 | 0.0709 |
Trichomonas vaginalis | DNA polymerase IV / kappa, putative | 0.0023 | 0.0108 | 0.5 |
Brugia malayi | ImpB/MucB/SamB family protein | 0.0023 | 0.0108 | 0.0149 |
Brugia malayi | hypothetical protein | 0.0029 | 0.032 | 0.0439 |
Brugia malayi | hypothetical protein | 0.0045 | 0.0809 | 0.111 |
Echinococcus granulosus | GA binding protein alpha chain | 0.0085 | 0.2012 | 0.2239 |
Echinococcus granulosus | protoporphyrinogen oxidase | 0.03 | 0.8607 | 1 |
Plasmodium falciparum | conserved Plasmodium protein, unknown function | 0.0045 | 0.0809 | 1 |
Leishmania major | hypothetical protein, conserved | 0.0029 | 0.032 | 0.3019 |
Plasmodium vivax | hypothetical protein, conserved | 0.0045 | 0.0809 | 1 |
Toxoplasma gondii | histone lysine-specific demethylase LSD1/BHC110/KDMA1A | 0.0045 | 0.0809 | 1 |
Mycobacterium tuberculosis | Conserved hypothetical protein | 0.0045 | 0.0809 | 0.0825 |
Loa Loa (eye worm) | hypothetical protein | 0.0045 | 0.0809 | 0.0976 |
Loa Loa (eye worm) | hypothetical protein | 0.0029 | 0.032 | 0.0295 |
Leishmania major | UDP-galactopyranose mutase | 0.0045 | 0.0809 | 1 |
Mycobacterium ulcerans | protoporphyrinogen oxidase | 0.0346 | 1 | 1 |
Schistosoma mansoni | gabp alpha | 0.0085 | 0.2012 | 0.1924 |
Echinococcus granulosus | lysine specific histone demethylase 1A | 0.0045 | 0.0809 | 0.0825 |
Plasmodium falciparum | protoporphyrinogen oxidase | 0.0045 | 0.0809 | 1 |
Toxoplasma gondii | histone lysine-specific demethylase | 0.0045 | 0.0809 | 1 |
Echinococcus multilocularis | lysine specific histone demethylase 1A | 0.0045 | 0.0809 | 0.0709 |
Loa Loa (eye worm) | hypothetical protein | 0.0045 | 0.0809 | 0.0976 |
Loa Loa (eye worm) | D-ets-4 DNA binding domain-containing protein | 0.0085 | 0.2012 | 0.2649 |
Mycobacterium ulcerans | dehydrogenase | 0.0045 | 0.0809 | 0.0709 |
Schistosoma mansoni | Lysine-specific histone demethylase 1 | 0.0045 | 0.0809 | 0.0709 |
Loa Loa (eye worm) | hypothetical protein | 0.0045 | 0.0809 | 0.0976 |
Brugia malayi | amine oxidase, flavin-containing family protein | 0.0045 | 0.0809 | 0.111 |
Trypanosoma brucei | PAB1-binding protein , putative | 0.0029 | 0.032 | 1 |
Plasmodium falciparum | lysine-specific histone demethylase 1, putative | 0.0045 | 0.0809 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0045 | 0.0809 | 0.0976 |
Trypanosoma cruzi | UDP-galactopyranose mutase | 0.0045 | 0.0809 | 1 |
Echinococcus multilocularis | 0.0045 | 0.0809 | 0.0709 | |
Schistosoma mansoni | amine oxidase | 0.0045 | 0.0809 | 0.0709 |
Loa Loa (eye worm) | hypothetical protein | 0.0045 | 0.0809 | 0.0976 |
Brugia malayi | Fli-1 protein | 0.0257 | 0.7294 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0072 | 0.1635 | 0.2125 |
Onchocerca volvulus | 0.0045 | 0.0809 | 0.5 | |
Mycobacterium tuberculosis | Possible oxidoreductase | 0.0045 | 0.0809 | 0.0825 |
Loa Loa (eye worm) | fli-1 protein | 0.0257 | 0.7294 | 1 |
Echinococcus multilocularis | GA binding protein alpha chain | 0.0085 | 0.2012 | 0.1924 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0029 | 0.032 | 0.3019 |
Schistosoma mansoni | ets-related | 0.0257 | 0.7294 | 0.7264 |
Mycobacterium leprae | PROBABLE PROTOPORPHYRINOGEN OXIDASE HEMY (PROTOPORPHYRINOGEN-IX OXIDASE) (PROTOPORPHYRINOGENASE) (PPO) | 0.0346 | 1 | 0.5 |
Schistosoma mansoni | Protoporphyrinogen oxidase chloroplast/mitochondrial precursor | 0.0346 | 1 | 1 |
Giardia lamblia | DINP protein human, muc B family | 0.0023 | 0.0108 | 0.5 |
Echinococcus multilocularis | protoporphyrinogen oxidase | 0.0346 | 1 | 1 |
Plasmodium vivax | hypothetical protein, conserved | 0.0045 | 0.0809 | 1 |
Mycobacterium ulcerans | flavin-containing monoamine oxidase AofH | 0.0045 | 0.0809 | 0.0709 |
Plasmodium vivax | protoporphyrinogen oxidase, putative | 0.0045 | 0.0809 | 1 |
Brugia malayi | ImpB/MucB/SamB family protein | 0.0023 | 0.0108 | 0.0149 |
Mycobacterium ulcerans | monoamine oxidase | 0.0045 | 0.0809 | 0.0709 |
Trypanosoma cruzi | UDP-galactopyranose mutase | 0.0045 | 0.0809 | 1 |
Entamoeba histolytica | deoxycytidyl transferase, putative | 0.0023 | 0.0108 | 0.5 |
Mycobacterium tuberculosis | Probable protoporphyrinogen oxidase HemY (protoporphyrinogen-IX oxidase) (protoporphyrinogenase) (PPO) | 0.03 | 0.8607 | 1 |
Schistosoma mansoni | amine oxidase | 0.0045 | 0.0809 | 0.0709 |
Brugia malayi | SWIRM domain containing protein | 0.0045 | 0.0809 | 0.111 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.