Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Entamoeba histolytica | hypothetical protein | 0.0036 | 0.0094 | 0.5 |
Echinococcus multilocularis | lysine specific histone demethylase 1A | 0.0152 | 0.1124 | 0.1039 |
Trypanosoma brucei | PAB1-binding protein , putative | 0.0025 | 0 | 0.5 |
Brugia malayi | hypothetical protein | 0.0152 | 0.1124 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0036 | 0.0094 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0152 | 0.1124 | 1 |
Plasmodium falciparum | protoporphyrinogen oxidase | 0.0152 | 0.1124 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0152 | 0.1124 | 1 |
Onchocerca volvulus | 0.0152 | 0.1124 | 0.5 | |
Trypanosoma cruzi | UDP-galactopyranose mutase | 0.0152 | 0.1124 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0152 | 0.1124 | 1 |
Plasmodium vivax | lysine-specific histone demethylase 1, putative | 0.0152 | 0.1124 | 1 |
Leishmania major | UDP-galactopyranose mutase | 0.0152 | 0.1124 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0152 | 0.1124 | 1 |
Echinococcus granulosus | lysine specific histone demethylase 1A | 0.0152 | 0.1124 | 0.1202 |
Plasmodium vivax | protoporphyrinogen oxidase, putative | 0.0152 | 0.1124 | 1 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0034 | 0.0078 | 0.0692 |
Plasmodium vivax | hypothetical protein, conserved | 0.0152 | 0.1124 | 1 |
Mycobacterium leprae | PROBABLE PROTOPORPHYRINOGEN OXIDASE HEMY (PROTOPORPHYRINOGEN-IX OXIDASE) (PROTOPORPHYRINOGENASE) (PPO) | 0.1156 | 1 | 0.5 |
Echinococcus granulosus | protoporphyrinogen oxidase | 0.1004 | 0.8655 | 1 |
Schistosoma mansoni | Protoporphyrinogen oxidase chloroplast/mitochondrial precursor | 0.1156 | 1 | 1 |
Echinococcus granulosus | lysine specific histone demethylase 1A | 0.0152 | 0.1124 | 0.1202 |
Toxoplasma gondii | histone lysine-specific demethylase | 0.0152 | 0.1124 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0152 | 0.1124 | 1 |
Plasmodium vivax | hypothetical protein, conserved | 0.0152 | 0.1124 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0036 | 0.0094 | 0.5 |
Brugia malayi | amine oxidase, flavin-containing family protein | 0.0152 | 0.1124 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0152 | 0.1124 | 1 |
Mycobacterium tuberculosis | Probable protoporphyrinogen oxidase HemY (protoporphyrinogen-IX oxidase) (protoporphyrinogenase) (PPO) | 0.1004 | 0.8655 | 1 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0049 | 0.0216 | 0.1924 |
Brugia malayi | hypothetical protein | 0.0036 | 0.0094 | 0.0841 |
Loa Loa (eye worm) | hypothetical protein | 0.0049 | 0.0216 | 0.1924 |
Echinococcus multilocularis | 0.0152 | 0.1124 | 0.1039 | |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0036 | 0.0094 | 0.0017 |
Schistosoma mansoni | Lysine-specific histone demethylase 1 | 0.0152 | 0.1124 | 0.1054 |
Loa Loa (eye worm) | hypothetical protein | 0.0034 | 0.0078 | 0.0692 |
Brugia malayi | SWIRM domain containing protein | 0.0152 | 0.1124 | 1 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0049 | 0.0216 | 0.1924 |
Echinococcus multilocularis | protoporphyrinogen oxidase | 0.1156 | 1 | 1 |
Toxoplasma gondii | histone lysine-specific demethylase LSD1/BHC110/KDMA1A | 0.0152 | 0.1124 | 1 |
Plasmodium falciparum | lysine-specific histone demethylase 1, putative | 0.0152 | 0.1124 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0036 | 0.0094 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0036 | 0.0094 | 0.0017 |
Schistosoma mansoni | amine oxidase | 0.0152 | 0.1124 | 0.1054 |
Plasmodium falciparum | conserved Plasmodium protein, unknown function | 0.0152 | 0.1124 | 1 |
Schistosoma mansoni | amine oxidase | 0.0152 | 0.1124 | 0.1054 |
Trypanosoma cruzi | UDP-galactopyranose mutase | 0.0152 | 0.1124 | 1 |
Mycobacterium ulcerans | protoporphyrinogen oxidase | 0.1156 | 1 | 1 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0049 | 0.0216 | 0.1924 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
EC50 | > 49.75 um | PUBCHEM_BIOASSAY: Late stage results from the probe development effort to identify inhibitors of Wee1 degradation. (Class of assay: screening) [Related pubchem assays (depositor defined):AID1321, AID1410, AID1412, AID1413, AID1414, AID1807, AID434972] Panel member name: Wee1 Degradation | ChEMBL. | No reference |
EC50 | > 49.75 um | PUBCHEM_BIOASSAY: Late stage results from the probe development effort to identify inhibitors of Wee1 degradation. (Class of assay: screening) [Related pubchem assays (depositor defined):AID1321, AID1410, AID1412, AID1413, AID1414, AID1807, AID434972] Panel member name: Cyclin B Degradation | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.