Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | glucagon-like peptide 1 receptor | Starlite/ChEMBL | No references |
Homo sapiens | geminin, DNA replication inhibitor | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Brugia malayi | Hypothetical 65.5 kDa Trp-Asp repeats containing protein F02E8.5 inchromosome X | geminin, DNA replication inhibitor | 209 aa | 176 aa | 27.8 % |
Loa Loa (eye worm) | pigment dispersing factor receptor c | glucagon-like peptide 1 receptor | 463 aa | 388 aa | 25.8 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Toxoplasma gondii | histone lysine-specific demethylase | 0.015 | 0 | 0.5 |
Echinococcus multilocularis | geminin | 0.0205 | 0.0553 | 0.0553 |
Toxoplasma gondii | histone lysine-specific demethylase LSD1/BHC110/KDMA1A | 0.015 | 0 | 0.5 |
Plasmodium vivax | protoporphyrinogen oxidase, putative | 0.015 | 0 | 0.5 |
Plasmodium falciparum | protoporphyrinogen oxidase | 0.015 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.015 | 0 | 0.5 |
Plasmodium vivax | hypothetical protein, conserved | 0.015 | 0 | 0.5 |
Brugia malayi | amine oxidase, flavin-containing family protein | 0.015 | 0 | 0.5 |
Brugia malayi | SWIRM domain containing protein | 0.015 | 0 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0205 | 0.0553 | 0.0553 |
Onchocerca volvulus | 0.015 | 0 | 0.5 | |
Loa Loa (eye worm) | hypothetical protein | 0.015 | 0 | 0.5 |
Plasmodium vivax | lysine-specific histone demethylase 1, putative | 0.015 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.015 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.015 | 0 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0205 | 0.0553 | 0.0553 |
Loa Loa (eye worm) | hypothetical protein | 0.015 | 0 | 0.5 |
Mycobacterium tuberculosis | Probable protoporphyrinogen oxidase HemY (protoporphyrinogen-IX oxidase) (protoporphyrinogenase) (PPO) | 0.0989 | 0.8485 | 1 |
Mycobacterium leprae | PROBABLE PROTOPORPHYRINOGEN OXIDASE HEMY (PROTOPORPHYRINOGEN-IX OXIDASE) (PROTOPORPHYRINOGENASE) (PPO) | 0.1139 | 1 | 0.5 |
Echinococcus granulosus | geminin | 0.0205 | 0.0553 | 0.0652 |
Mycobacterium ulcerans | protoporphyrinogen oxidase | 0.1139 | 1 | 1 |
Plasmodium falciparum | lysine-specific histone demethylase 1, putative | 0.015 | 0 | 0.5 |
Leishmania major | UDP-galactopyranose mutase | 0.015 | 0 | 0.5 |
Brugia malayi | hypothetical protein | 0.015 | 0 | 0.5 |
Schistosoma mansoni | Protoporphyrinogen oxidase chloroplast/mitochondrial precursor | 0.1139 | 1 | 1 |
Trypanosoma cruzi | UDP-galactopyranose mutase | 0.015 | 0 | 0.5 |
Plasmodium vivax | hypothetical protein, conserved | 0.015 | 0 | 0.5 |
Echinococcus multilocularis | protoporphyrinogen oxidase | 0.1139 | 1 | 1 |
Plasmodium falciparum | conserved Plasmodium protein, unknown function | 0.015 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.015 | 0 | 0.5 |
Trypanosoma cruzi | UDP-galactopyranose mutase | 0.015 | 0 | 0.5 |
Echinococcus granulosus | protoporphyrinogen oxidase | 0.0989 | 0.8485 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 4.1095 uM | PubChem BioAssay. A quantitative high throughput screen for small molecules that induce DNA re-replication in SW480 colon adenocarcinoma cells. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 8.9125 uM | PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 10.4179 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Potency (functional) | 28.1838 uM | PubChem BioAssay. qHTS for Activators of Integrin-Mediated Alleviation for Muscular Dystrophy. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 100 uM | PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Plasmodium falciparum | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.