TDR Targets

Basic information

Technical information

TDR Targets ID: 1499395
Name: N-cyclohexyl-5-methyl-4-nitro-1,2-oxazole-3-c arboxamide
MW: 253.254 | Formula: C11H15N3O4
H donors: 1 H acceptors: 4 LogP: 2.02 Rotable bonds: 4
Rule of 5 violations (Lipinski): 1
SMILES: O=C(c1noc(c1[N+](=O)[O-])C)NC1CCCCC1
InChi: 1S/C11H15N3O4/c1-7-10(14(16)17)9(13-18-7)11(15)12-8-5-3-2-4-6-8/h8H,2-6H2,1H3,(H,12,15)
InChiKey: KSHBLOBHIQVQNY-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

N-cyclohexyl-5-methyl-4-nitro-isoxazole-3-carboxamide
N-cyclohexyl-5-methyl-4-nitro-3-isoxazolecarboxamide

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	ataxin 2	Starlite/ChEMBL	No references

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Mycobacterium tuberculosis	Thymidylate kinase Tmk (dTMP kinase) (thymidylic acid kinase) (TMPK)	0.0073	0.2864	0.5
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0434	0.0434
Echinococcus multilocularis	peptide (allatostatin:somatostatin)	0.0041	0.0434	0.0434
Schistosoma mansoni	peptide (allatostatin)-like receptor	0.0041	0.0434	0.0434
Echinococcus multilocularis	neuropeptide s receptor	0.0041	0.0434	0.0434
Echinococcus granulosus	g-protein coupled receptor	0.0041	0.0434	0.0434
Schistosoma mansoni	hypothetical protein	0.0041	0.0434	0.0434
Echinococcus multilocularis	allatostatin A receptor	0.0041	0.0434	0.0434
Onchocerca volvulus		0.0041	0.0434	0.1251
Schistosoma mansoni	biogenic amine receptor	0.0041	0.0434	0.0434
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0434	0.0434
Onchocerca volvulus		0.0041	0.0434	0.1251
Echinococcus granulosus	allatostatin A receptor	0.0041	0.0434	0.0434
Schistosoma mansoni	amine GPCR	0.0041	0.0434	0.0434
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0041	0.0434	0.0434
Echinococcus granulosus	tm gpcr rhodopsin	0.0041	0.0434	0.0434
Echinococcus granulosus	rhodopsin orphan GPCR	0.0041	0.0434	0.0434
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0434	0.0434
Echinococcus multilocularis	thyrotropin releasing hormone receptor	0.0041	0.0434	0.0434
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0434	0.0434
Loa Loa (eye worm)	neuropeptide F receptor	0.0041	0.0434	0.0434
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0434	0.0434
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0434	0.0434
Onchocerca volvulus		0.0041	0.0434	0.1251
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0434	0.0434
Schistosoma mansoni	hypothetical protein	0.0041	0.0434	0.0434
Loa Loa (eye worm)	5-hydroxytryptamine 2C receptor	0.0041	0.0434	0.0434
Schistosoma mansoni	growth hormone secretagogue receptor	0.0041	0.0434	0.0434
Brugia malayi	Melatonin receptor type 1A	0.0041	0.0434	0.0434
Brugia malayi	Dopamine receptor protein 1	0.0041	0.0434	0.0434
Echinococcus granulosus	neuropeptide Y receptor	0.0041	0.0434	0.0434
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0434	0.0434
Treponema pallidum	thymidylate kinase (tmk)	0.0073	0.2864	0.5
Trypanosoma brucei	Eukaryotic translation initiation factor 4E-1	0.0169	1	1
Echinococcus granulosus	neuropeptides capa receptor	0.0041	0.0434	0.0434
Plasmodium vivax	thymidylate kinase, putative	0.0073	0.2864	1
Echinococcus granulosus	rhodopsin orphan GPCR	0.0041	0.0434	0.0434
Schistosoma mansoni	amine GPCR	0.0041	0.0434	0.0434
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0041	0.0434	0.0434
Echinococcus granulosus	g protein coupled receptor	0.0041	0.0434	0.0434
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0041	0.0434	0.0434
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0434	0.0434
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0434	0.0434
Brugia malayi	hypothetical protein	0.0041	0.0434	0.0434
Echinococcus multilocularis	neuropeptide receptor	0.0041	0.0434	0.0434
Onchocerca volvulus		0.0041	0.0434	0.1251
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0434	0.0434
Schistosoma mansoni	neuropeptide F-like receptor	0.0041	0.0434	0.0434
Echinococcus granulosus	g protein coupled receptor	0.0041	0.0434	0.0434
Echinococcus multilocularis	neuropeptide Y receptor	0.0041	0.0434	0.0434
Echinococcus granulosus	rhodopsin orphan GPCR	0.0041	0.0434	0.0434
Mycobacterium leprae	probable thymidylate kinase Tmk (dTMP KINASE) (THYMIDYLIC ACID KINASE) (TMPK)	0.0073	0.2864	0.5
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0041	0.0434	0.0434
Echinococcus multilocularis	neuropeptide FF receptor 2	0.0041	0.0434	0.0434
Onchocerca volvulus		0.0041	0.0434	0.1251
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0434	0.0434
Schistosoma mansoni	aminoadipate-semialdehyde dehydrogenase	0.0082	0.3468	0.3468
Echinococcus multilocularis	tachykinin peptides receptor 99D	0.0041	0.0434	0.0434
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0434	0.0434
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0041	0.0434	0.0434
Echinococcus granulosus	fmrfamide receptor	0.0041	0.0434	0.0434
Brugia malayi	hypothetical protein	0.0041	0.0434	0.0434
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0434	0.0434
Brugia malayi	Serotonin/octopamine receptor family protein 7	0.0041	0.0434	0.0434
Schistosoma mansoni	amine GPCR	0.0041	0.0434	0.0434
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0041	0.0434	0.0434
Schistosoma mansoni	neuropeptide receptor	0.0041	0.0434	0.0434
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0041	0.0434	0.0434
Echinococcus granulosus	neuropeptide Y receptor	0.0041	0.0434	0.0434
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0041	0.0434	0.0434
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0434	0.0434
Echinococcus multilocularis	g protein coupled receptor	0.0041	0.0434	0.0434
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0041	0.0434	0.0434
Schistosoma mansoni	opsin-like receptor	0.0041	0.0434	0.0434
Wolbachia endosymbiont of Brugia malayi	thymidylate kinase	0.0073	0.2864	0.5
Echinococcus granulosus	neuropeptide FF receptor 2	0.0041	0.0434	0.0434
Echinococcus granulosus	orexin receptor type 2	0.0041	0.0434	0.0434
Schistosoma mansoni	hypothetical protein	0.0041	0.0434	0.0434
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0434	0.0434
Echinococcus granulosus	peptide allatostatin:somatostatin	0.0041	0.0434	0.0434
Brugia malayi	G protein-coupled receptor	0.0041	0.0434	0.0434
Echinococcus multilocularis	dro:myosuppressin receptor	0.0041	0.0434	0.0434
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0041	0.0434	0.0434
Echinococcus granulosus	tachykinin peptides receptor 99D	0.0041	0.0434	0.0434
Echinococcus multilocularis	neuropeptides capa receptor	0.0041	0.0434	0.0434
Onchocerca volvulus		0.0041	0.0434	0.1251
Echinococcus multilocularis	growth hormone secretagogue receptor type 1	0.0041	0.0434	0.0434
Echinococcus multilocularis	G protein coupled receptor 139	0.0041	0.0434	0.0434
Onchocerca volvulus		0.0041	0.0434	0.1251
Schistosoma mansoni	histamine-responsive GPCR (AAF21638)	0.0041	0.0434	0.0434
Trichomonas vaginalis	eukaryotic translation initiation factor 4E, putative	0.0169	1	1
Schistosoma mansoni	hypothetical protein	0.0041	0.0434	0.0434
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0041	0.0434	0.0434
Echinococcus multilocularis	G-protein coupled receptor, putative	0.0041	0.0434	0.0434
Echinococcus granulosus	neuropeptide receptor	0.0041	0.0434	0.0434
Loa Loa (eye worm)	gonadotropin-releasing hormone receptor 2	0.0041	0.0434	0.0434
Schistosoma mansoni	opsin-like receptor	0.0041	0.0434	0.0434
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0434	0.0434
Brugia malayi	G protein-coupled receptor F59B2.13	0.0041	0.0434	0.0434
Echinococcus granulosus	serotonin receptor	0.0041	0.0434	0.0434
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0041	0.0434	0.0434
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0434	0.0434
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0041	0.0434	0.0434
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0434	0.0434
Trichomonas vaginalis	eukaryotic translation initiation factor 4E, putative	0.0169	1	1
Loa Loa (eye worm)	G-protein coupled receptor	0.0041	0.0434	0.0434
Echinococcus granulosus	G protein coupled receptor 139	0.0041	0.0434	0.0434
Plasmodium falciparum	thymidylate kinase	0.0073	0.2864	1
Echinococcus granulosus	sex peptide receptor	0.0041	0.0434	0.0434
Schistosoma mansoni	biogenic amine (octopamine/dopamine) receptor	0.0041	0.0434	0.0434
Echinococcus granulosus	rhodopsin orphan GPCR	0.0041	0.0434	0.0434
Toxoplasma gondii	eukaryotic initiation factor-4E, putative	0.0169	1	1
Schistosoma mansoni	eukaryotic translation initiation factor 4e	0.0169	1	1
Echinococcus multilocularis	somatostatin receptor	0.0041	0.0434	0.0434
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0434	0.0434
Brugia malayi	larval opioid receptor	0.0041	0.0434	0.0434
Echinococcus multilocularis	neuropeptides capa receptor	0.0041	0.0434	0.0434
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0434	0.0434
Onchocerca volvulus		0.0041	0.0434	0.1251
Brugia malayi	Tachykinin-like peptides receptor 99D	0.0041	0.0434	0.0434
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0041	0.0434	0.0434
Schistosoma mansoni	ancient conserved domain protein 2 (cyclin m2)	0.0041	0.0434	0.0434
Schistosoma mansoni	biogenic amine receptor	0.0041	0.0434	0.0434
Brugia malayi	Serotonin receptor	0.0041	0.0434	0.0434
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0041	0.0434	0.0434
Brugia malayi	Dopamine receptor	0.0041	0.0434	0.0434
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0434	0.0434
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0041	0.0434	0.0434
Brugia malayi	putative neuropeptide receptor NPR1	0.0041	0.0434	0.0434
Echinococcus granulosus	thymidylate kinase	0.0073	0.2864	0.2864
Onchocerca volvulus	Putative thymidylate kinase	0.0073	0.2864	0.8257
Brugia malayi	G-protein coupled receptor	0.0041	0.0434	0.0434
Schistosoma mansoni	opsin-like receptor	0.0041	0.0434	0.0434
Brugia malayi	hypothetical protein	0.0041	0.0434	0.0434
Echinococcus granulosus	neuropeptide receptor	0.0041	0.0434	0.0434
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0041	0.0434	0.0434
Schistosoma mansoni	neuropeptide receptor	0.0041	0.0434	0.0434
Echinococcus granulosus	hypothetical protein	0.0041	0.0434	0.0434
Loa Loa (eye worm)	thymidylate kinase	0.0073	0.2864	0.2864
Echinococcus multilocularis	sex peptide receptor	0.0041	0.0434	0.0434
Echinococcus granulosus	growth hormone secretagogue receptor type 1	0.0041	0.0434	0.0434
Leishmania major	thymidylate kinase-like protein	0.0073	0.2864	0.2864
Echinococcus granulosus	g protein coupled receptor	0.0041	0.0434	0.0434
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0434	0.0434
Brugia malayi	G-protein coupled receptor	0.0041	0.0434	0.0434
Echinococcus granulosus	7tm_1 domain containing protein	0.0041	0.0434	0.0434
Schistosoma mansoni	neuropeptide receptor	0.0041	0.0434	0.0434
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0434	0.0434
Brugia malayi	GnHR receptor homolog	0.0041	0.0434	0.0434
Echinococcus multilocularis	g protein coupled receptor	0.0041	0.0434	0.0434
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0041	0.0434	0.0434
Loa Loa (eye worm)	G-protein-linked acetylcholine receptor protein 2	0.0041	0.0434	0.0434
Echinococcus granulosus	neuropeptide s receptor	0.0041	0.0434	0.0434
Onchocerca volvulus		0.0041	0.0434	0.1251
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0434	0.0434
Onchocerca volvulus		0.0041	0.0434	0.1251
Brugia malayi	hypothetical protein	0.0041	0.0434	0.0434
Onchocerca volvulus		0.0041	0.0434	0.1251
Leishmania major	eukaryotic translation initiation factor eIF-4E, putative	0.0169	1	1
Schistosoma mansoni	thyrotropin-releasing hormone receptor	0.0041	0.0434	0.0434
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0041	0.0434	0.0434
Brugia malayi	G-protein-linked acetylcholine receptor protein 2, putative	0.0041	0.0434	0.0434
Schistosoma mansoni	thymidylate kinase	0.0073	0.2864	0.2864
Schistosoma mansoni	histamine h1 receptor	0.0041	0.0434	0.0434
Schistosoma mansoni	adenoreceptor	0.0041	0.0434	0.0434
Onchocerca volvulus		0.0082	0.3468	1
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0434	0.0434
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0434	0.0434
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0041	0.0434	0.0434
Brugia malayi	hypothetical protein	0.0041	0.0434	0.0434
Echinococcus multilocularis	eukaryotic translation initiation factor 4E	0.0169	1	1
Brugia malayi	Dopamine receptor protein 1, putative (partial)	0.0041	0.0434	0.0434
Brugia malayi	Unidentified vitellogenin-linked transcript protein 6, putative	0.0041	0.0434	0.0434
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0434	0.0434
Echinococcus granulosus	tm gpcr rhodopsin	0.0041	0.0434	0.0434
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0041	0.0434	0.0434
Brugia malayi	ORL1-like opioid receptor	0.0041	0.0434	0.0434
Echinococcus multilocularis	L aminoadipate semialdehyde	0.0082	0.3468	0.3468
Echinococcus granulosus	thyrotropin releasing hormone receptor	0.0041	0.0434	0.0434
Echinococcus multilocularis	fmrfamide receptor	0.0041	0.0434	0.0434
Brugia malayi	RE15519p	0.0041	0.0434	0.0434
Chlamydia trachomatis	thymidylate kinase	0.0073	0.2864	0.5
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0434	0.0434
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0041	0.0434	0.0434
Brugia malayi	hypothetical protein	0.0041	0.0434	0.0434
Brugia malayi	gonadotropin-releasing hormone receptor 2	0.0041	0.0434	0.0434
Echinococcus granulosus	dro:myosuppressin receptor	0.0041	0.0434	0.0434
Echinococcus multilocularis	neuropeptide receptor	0.0041	0.0434	0.0434
Loa Loa (eye worm)	G-protein coupled receptor	0.0041	0.0434	0.0434
Brugia malayi	Serotonin receptor	0.0041	0.0434	0.0434
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0041	0.0434	0.0434
Trypanosoma cruzi	thymidylate kinase, putative	0.0073	0.2864	0.2864
Brugia malayi	hypothetical protein	0.0041	0.0434	0.0434
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0434	0.0434
Brugia malayi	hypothetical protein	0.0041	0.0434	0.0434
Brugia malayi	Dopamine receptor protein 2	0.0041	0.0434	0.0434
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0041	0.0434	0.0434
Schistosoma mansoni	biogenic amine receptor	0.0041	0.0434	0.0434
Trypanosoma cruzi	Eukaryotic translation initiation factor 4E-1	0.0169	1	1
Onchocerca volvulus	Neuropeptide F receptor homolog	0.0041	0.0434	0.1251
Onchocerca volvulus		0.0041	0.0434	0.1251
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0434	0.0434
Schistosoma mansoni	peptide (allatostatin/somatostatin)-like receptor	0.0041	0.0434	0.0434
Echinococcus granulosus	biogenic amine 5HT receptor	0.0041	0.0434	0.0434
Brugia malayi	AKH receptor	0.0041	0.0434	0.0434
Echinococcus granulosus	eukaryotic translation initiation factor 4E	0.0169	1	1
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0041	0.0434	0.0434
Leishmania major	eukaryotic translation initiation factor-like	0.0169	1	1
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0434	0.0434
Onchocerca volvulus		0.0041	0.0434	0.1251
Onchocerca volvulus	Dopamine\/Ecdysteroid receptor homolog	0.0041	0.0434	0.1251
Schistosoma mansoni	amine GPCR	0.0041	0.0434	0.0434
Onchocerca volvulus		0.0041	0.0434	0.1251
Echinococcus granulosus	L aminoadipate semialdehyde	0.0082	0.3468	0.3468
Schistosoma mansoni	neuropeptide receptor	0.0041	0.0434	0.0434
Trypanosoma cruzi	thymidylate kinase, putative	0.0073	0.2864	0.2864
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0434	0.0434
Loa Loa (eye worm)	hypothetical protein	0.0082	0.3468	0.3468
Brugia malayi	putative neuropeptide receptor	0.0041	0.0434	0.0434
Echinococcus multilocularis	g-protein coupled receptor	0.0041	0.0434	0.0434
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0041	0.0434	0.0434
Echinococcus granulosus	rhodopsin orphan GPCR	0.0041	0.0434	0.0434
Entamoeba histolytica	eukaryotic translation initiation factor 4E, putative	0.0169	1	1
Echinococcus multilocularis	thymidylate kinase	0.0073	0.2864	0.2864
Echinococcus multilocularis	g protein coupled receptor	0.0041	0.0434	0.0434
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0434	0.0434
Brugia malayi	neuropeptide F receptor	0.0041	0.0434	0.0434
Schistosoma mansoni	peptide (FMRFamide/neurokinin-3)-like receptor	0.0041	0.0434	0.0434
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0041	0.0434	0.0434
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0434	0.0434
Brugia malayi	thymidylate kinase	0.0073	0.2864	0.2864
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0041	0.0434	0.0434
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0434	0.0434
Onchocerca volvulus		0.0041	0.0434	0.1251
Schistosoma mansoni	muscarinic acetylcholine (GAR) receptor	0.0041	0.0434	0.0434
Echinococcus granulosus	neuropeptide receptor A26	0.0041	0.0434	0.0434
Toxoplasma gondii	thymidylate kinase	0.0073	0.2864	0.2864
Echinococcus multilocularis	G protein coupled 5 hydroxytryptamine receptor	0.0041	0.0434	0.0434
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0434	0.0434
Mycobacterium ulcerans	thymidylate kinase	0.0073	0.2864	0.5
Schistosoma mansoni	myosin xvIII	0.0041	0.0434	0.0434
Echinococcus granulosus	7TM GPCR rhodopsin	0.0041	0.0434	0.0434
Loa Loa (eye worm)	unidentified vitellogenin-linked transcript protein 6	0.0041	0.0434	0.0434
Echinococcus granulosus	pyroglutamylated rfamide peptide receptor	0.0041	0.0434	0.0434
Entamoeba histolytica	eukaryotic translation initiation factor 4E, putative	0.0169	1	1
Brugia malayi	hypothetical protein	0.0041	0.0434	0.0434
Echinococcus granulosus	tm gpcr rhodopsin	0.0041	0.0434	0.0434
Brugia malayi	follicle stimulating hormone receptor	0.0041	0.0434	0.0434
Echinococcus multilocularis	serotonin receptor	0.0041	0.0434	0.0434
Schistosoma mansoni	neuropeptide f receptor 76f	0.0041	0.0434	0.0434
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0434	0.0434
Echinococcus multilocularis	orexin receptor type 2	0.0041	0.0434	0.0434
Schistosoma mansoni	alpha-1 adrenergic receptor	0.0041	0.0434	0.0434
Loa Loa (eye worm)	melatonin receptor type 1A	0.0041	0.0434	0.0434
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0434	0.0434
Loa Loa (eye worm)	neuropeptide F receptor	0.0041	0.0434	0.0434
Echinococcus multilocularis	biogenic amine (5HT) receptor	0.0041	0.0434	0.0434
Brugia malayi	neuropeptide F receptor	0.0041	0.0434	0.0434
Trypanosoma cruzi	Eukaryotic translation initiation factor 4E-1	0.0169	1	1
Echinococcus granulosus	rhodopsin orphan GPCR	0.0041	0.0434	0.0434
Loa Loa (eye worm)	TYRA-2 protein	0.0041	0.0434	0.0434
Echinococcus multilocularis	fmrfamide receptor	0.0041	0.0434	0.0434
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0434	0.0434
Echinococcus multilocularis	pyroglutamylated rfamide peptide receptor	0.0041	0.0434	0.0434
Trichomonas vaginalis	eukaryotic translation initiation factor 4E, putative	0.0169	1	1
Echinococcus multilocularis	neuropeptide receptor A26	0.0041	0.0434	0.0434
Schistosoma mansoni	neuropeptide F-like receptor	0.0041	0.0434	0.0434
Echinococcus multilocularis	7TM GPCR, rhodopsin	0.0041	0.0434	0.0434
Echinococcus multilocularis	alpha 1A adrenergic receptor	0.0041	0.0434	0.0434
Echinococcus granulosus	alpha 1A adrenergic receptor	0.0041	0.0434	0.0434
Echinococcus granulosus	rhodopsin orphan GPCR	0.0041	0.0434	0.0434
Echinococcus multilocularis	serotonin receptor	0.0041	0.0434	0.0434
Schistosoma mansoni	amine GPCR	0.0041	0.0434	0.0434
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0041	0.0434	0.0434
Onchocerca volvulus		0.0041	0.0434	0.1251
Loa Loa (eye worm)	translation initiation factor 4E	0.0169	1	1
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0434	0.0434
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0434	0.0434
Onchocerca volvulus		0.0041	0.0434	0.1251
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0434	0.0434
Echinococcus multilocularis	neuropeptide Y receptor	0.0041	0.0434	0.0434
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0434	0.0434
Schistosoma mansoni	hypothetical protein	0.0073	0.2864	0.2864
Loa Loa (eye worm)	hypothetical protein	0.0041	0.0434	0.0434
Loa Loa (eye worm)	follicle stimulating hormone receptor	0.0041	0.0434	0.0434
Leishmania major	eukaryotic translation initiation factor-like protein	0.0169	1	1
Brugia malayi	aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase	0.0082	0.3468	0.3468
Echinococcus granulosus	biogenic amine 5HT receptor	0.0041	0.0434	0.0434
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0041	0.0434	0.0434
Brugia malayi	sulfakinin receptor protein	0.0041	0.0434	0.0434
Echinococcus granulosus	somatostatin receptor	0.0041	0.0434	0.0434
Trichomonas vaginalis	eukaryotic translation initiation factor 4E, putative	0.0169	1	1
Schistosoma mansoni	thymidylate kinase	0.0073	0.2864	0.2864
Brugia malayi	hypothetical protein	0.0041	0.0434	0.0434
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0041	0.0434	0.0434
Giardia lamblia	CDC8	0.0073	0.2864	0.5
Echinococcus granulosus	neuropeptides capa receptor	0.0041	0.0434	0.0434
Echinococcus granulosus	G protein coupled 5 hydroxytryptamine receptor	0.0041	0.0434	0.0434

Activities

Activity type	Activity value	Assay description	Source	Reference
Potency (functional)	1.122 uM	PubChem BioAssay. qHTS for Inhibitors of ATXN expression. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	18.526 uM	PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850]	ChEMBL.	No reference
Potency (functional)	50.1187 uM	PUBCHEM_BIOASSAY: qHTS assay for re-activators of p53 using a Luc reporter. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504709]	ChEMBL.	No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name	Source	Reference	Is orphan
Plasmodium falciparum	ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL1715836

Bibliographic References

No literature references available for this target.

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Detailed information for compound 1499395