Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Schistosoma japonicum | Integrin beta-3 precursor, putative | Get druggable targets OG5_127959 | All targets in OG5_127959 |
Loa Loa (eye worm) | integrin beta-2 | Get druggable targets OG5_127959 | All targets in OG5_127959 |
Echinococcus multilocularis | integrin beta 2 | Get druggable targets OG5_127959 | All targets in OG5_127959 |
Schistosoma mansoni | integrin beta subunit | Get druggable targets OG5_127959 | All targets in OG5_127959 |
Schistosoma japonicum | ko:K06464 integrin beta 2, putative | Get druggable targets OG5_127959 | All targets in OG5_127959 |
Schistosoma japonicum | Integrin beta-PS precursor, putative | Get druggable targets OG5_127959 | All targets in OG5_127959 |
Echinococcus granulosus | integrin beta 2 | Get druggable targets OG5_127959 | All targets in OG5_127959 |
Brugia malayi | Integrin beta pat-3 precursor | Get druggable targets OG5_127959 | All targets in OG5_127959 |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | integrin beta 2 | 0.028 | 0.0088 | 0.5 |
Treponema pallidum | licC protein (licC) | 0.1154 | 0.1426 | 0.5 |
Toxoplasma gondii | eukaryotic initiation factor-2B, gamma subunit, putative | 0.1154 | 0.1426 | 0.5 |
Mycobacterium ulcerans | bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase | 0.675 | 1 | 1 |
Echinococcus granulosus | integrin beta 2 | 0.028 | 0.0088 | 0.5 |
Loa Loa (eye worm) | integrin beta-2 | 0.0378 | 0.0238 | 0.5 |
Schistosoma mansoni | integrin beta subunit | 0.0223 | 0 | 0.5 |
Brugia malayi | Integrin beta pat-3 precursor | 0.0378 | 0.0238 | 0.5 |
Wolbachia endosymbiont of Brugia malayi | N-acetylglucosamine-1-phosphate uridyltransferase | 0.675 | 1 | 0.5 |
Mycobacterium tuberculosis | Probable UDP-N-acetylglucosamine pyrophosphorylase GlmU | 0.675 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = -0.65 nM | Inhibitory activity against very late antigen-4 (VLA-4) using VCAM-Ig ligand. | ChEMBL. | 11844689 |
IC50 (functional) | = 0.63 nM | Antagonistic activity against VLA-4 integrin of human jurkat cells using [125I]-VCAM-Ig as radioligand | ChEMBL. | 11591507 |
IC50 (functional) | = 0.63 nM | Antagonistic activity against VLA-4 integrin of human jurkat cells using [125I]-VCAM-Ig as radioligand | ChEMBL. | 11591507 |
IC50 (binding) | = 0.65 nM | Inhibitory activity against very late antigen-4 (VLA-4) using VCAM-Ig ligand. | ChEMBL. | 11844689 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
2 literature references were collected for this gene.