Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Loa Loa (eye worm) | integrin beta-2 | Get druggable targets OG5_127959 | All targets in OG5_127959 |
Schistosoma japonicum | Integrin beta-PS precursor, putative | Get druggable targets OG5_127959 | All targets in OG5_127959 |
Schistosoma japonicum | Integrin beta-3 precursor, putative | Get druggable targets OG5_127959 | All targets in OG5_127959 |
Echinococcus multilocularis | integrin beta 2 | Get druggable targets OG5_127959 | All targets in OG5_127959 |
Echinococcus granulosus | integrin beta 2 | Get druggable targets OG5_127959 | All targets in OG5_127959 |
Schistosoma mansoni | integrin beta subunit | Get druggable targets OG5_127959 | All targets in OG5_127959 |
Brugia malayi | Integrin beta pat-3 precursor | Get druggable targets OG5_127959 | All targets in OG5_127959 |
Schistosoma japonicum | ko:K06464 integrin beta 2, putative | Get druggable targets OG5_127959 | All targets in OG5_127959 |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | integrin beta subunit | 0.0223 | 0 | 0.5 |
Treponema pallidum | licC protein (licC) | 0.1154 | 0.1426 | 0.5 |
Echinococcus multilocularis | integrin beta 2 | 0.028 | 0.0088 | 0.5 |
Mycobacterium tuberculosis | Probable UDP-N-acetylglucosamine pyrophosphorylase GlmU | 0.675 | 1 | 1 |
Echinococcus granulosus | integrin beta 2 | 0.028 | 0.0088 | 0.5 |
Mycobacterium ulcerans | bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase | 0.675 | 1 | 1 |
Wolbachia endosymbiont of Brugia malayi | N-acetylglucosamine-1-phosphate uridyltransferase | 0.675 | 1 | 0.5 |
Brugia malayi | Integrin beta pat-3 precursor | 0.0378 | 0.0238 | 0.5 |
Loa Loa (eye worm) | integrin beta-2 | 0.0378 | 0.0238 | 0.5 |
Toxoplasma gondii | eukaryotic initiation factor-2B, gamma subunit, putative | 0.1154 | 0.1426 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = -0.65 nM | Inhibitory activity against very late antigen-4 (VLA-4) using VCAM-Ig ligand. | ChEMBL. | 11844689 |
IC50 (functional) | = 0.63 nM | Antagonistic activity against VLA-4 integrin of human jurkat cells using [125I]-VCAM-Ig as radioligand | ChEMBL. | 11591507 |
IC50 (functional) | = 0.63 nM | Antagonistic activity against VLA-4 integrin of human jurkat cells using [125I]-VCAM-Ig as radioligand | ChEMBL. | 11591507 |
IC50 (binding) | = 0.65 nM | Inhibitory activity against very late antigen-4 (VLA-4) using VCAM-Ig ligand. | ChEMBL. | 11844689 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
2 literature references were collected for this gene.