Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | glutamate receptor, metabotropic 2 | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | Metabotropic glutamate receptor precursor. | 0.0061 | 0.4011 | 0.4011 |
Echinococcus multilocularis | metabotropic glutamate receptor 5 | 0.0075 | 0.5819 | 0.4241 |
Loa Loa (eye worm) | glycogen phosphorylase | 0.0108 | 1 | 1 |
Schistosoma mansoni | glycogen phosphorylase | 0.0047 | 0.2159 | 0.2159 |
Entamoeba histolytica | glycogen phosphorylase, putative | 0.0108 | 1 | 1 |
Echinococcus granulosus | glycogen phosphorylase | 0.0108 | 1 | 1 |
Schistosoma mansoni | metabotropic glutamate receptor | 0.0051 | 0.2741 | 0.2741 |
Echinococcus granulosus | Glycosyl transferase family 35 | 0.0108 | 1 | 1 |
Onchocerca volvulus | Glycogen phosphorylase homolog | 0.0108 | 1 | 0.5 |
Echinococcus granulosus | metabotropic glutamate receptor 5 | 0.0075 | 0.5819 | 0.4241 |
Loa Loa (eye worm) | hypothetical protein | 0.0075 | 0.5819 | 0.3019 |
Brugia malayi | metabotropic glutamate receptor subtype 5a (mGluR5a), putative | 0.0055 | 0.3275 | 0.3275 |
Entamoeba histolytica | glycogen phosphorylase, putative | 0.0108 | 1 | 1 |
Echinococcus granulosus | glycogen phosphorylase | 0.0108 | 1 | 1 |
Mycobacterium ulcerans | glycogen phosphorylase GlgP | 0.0047 | 0.2159 | 0.5 |
Chlamydia trachomatis | glycogen phosphorylase | 0.0108 | 1 | 0.5 |
Echinococcus multilocularis | glycogen phosphorylase | 0.0108 | 1 | 1 |
Schistosoma mansoni | metabotropic glutamate receptor 2 3 (mglur group 2) | 0.0069 | 0.5084 | 0.5084 |
Mycobacterium tuberculosis | Probable glycogen phosphorylase GlgP | 0.0047 | 0.2159 | 0.5 |
Schistosoma mansoni | glycogen phosphorylase | 0.0108 | 1 | 1 |
Echinococcus multilocularis | Glycosyl transferase, family 35 | 0.0108 | 1 | 1 |
Trichomonas vaginalis | glycogen phosphorylase, putative | 0.0108 | 1 | 0.5 |
Trichomonas vaginalis | glycogen phosphorylase, putative | 0.0108 | 1 | 0.5 |
Schistosoma mansoni | glycogen phosphorylase | 0.0108 | 1 | 1 |
Echinococcus multilocularis | glycogen phosphorylase | 0.0108 | 1 | 1 |
Giardia lamblia | Glycogen phosphorylase | 0.0108 | 1 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
EC50 (binding) | = 5.5 | Agonist activity at human mGluR2 expressed in CHO cells at by [S35]GTPgammaS binding assay | ChEMBL. | 21232953 |
Emax (binding) | = 82 % | Agonist activity at human mGluR2 expressed in CHO cells at by [S35]GTPgammaS binding assay relative to glutamate | ChEMBL. | 21232953 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.