Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | kinase insert domain receptor | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Onchocerca volvulus | Get druggable targets OG5_130320 | All targets in OG5_130320 | |
Onchocerca volvulus | Tyrosine kinase homolog | Get druggable targets OG5_130320 | All targets in OG5_130320 |
Brugia malayi | Immunoglobulin I-set domain containing protein | Get druggable targets OG5_130320 | All targets in OG5_130320 |
Loa Loa (eye worm) | TK/KIN16 protein kinase | Get druggable targets OG5_130320 | All targets in OG5_130320 |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Toxoplasma gondii | apocytochrome b, putative | 0.0517 | 1 | 0.5 |
Schistosoma mansoni | Neurotrimin precursor (hNT) | 0.0011 | 0.0072 | 0.0072 |
Toxoplasma gondii | cytochrome b | 0.0517 | 1 | 0.5 |
Echinococcus granulosus | neurotracting:lsamp:neurotrimin:obcam | 0.0015 | 0.0144 | 0.0072 |
Loa Loa (eye worm) | hypothetical protein | 0.0015 | 0.0144 | 0.0072 |
Schistosoma mansoni | vesicular amine transporter | 0.0011 | 0.0072 | 0.0072 |
Echinococcus granulosus | twitchin | 0.0014 | 0.0129 | 0.0057 |
Brugia malayi | Immunoglobulin I-set domain containing protein | 0.0183 | 0.3439 | 0.3391 |
Echinococcus multilocularis | roundabout 2 | 0.0018 | 0.0201 | 1 |
Onchocerca volvulus | Tyrosine kinase homolog | 0.0171 | 0.3203 | 1 |
Wolbachia endosymbiont of Brugia malayi | cytochrome b subunit of the bc complex | 0.0517 | 1 | 0.5 |
Schistosoma mansoni | nephrin | 0.0014 | 0.0129 | 0.0129 |
Echinococcus multilocularis | neuroglian | 0.0014 | 0.0129 | 0.4393 |
Schistosoma mansoni | defective proboscis extension response (dpr)-related | 0.0011 | 0.0072 | 0.0072 |
Plasmodium vivax | cytochrome b | 0.0517 | 1 | 0.5 |
Plasmodium falciparum | cytochrome b | 0.0517 | 1 | 0.5 |
Schistosoma mansoni | cytochrome b | 0.0517 | 1 | 1 |
Echinococcus granulosus | cytochrome B | 0.0517 | 1 | 1 |
Echinococcus granulosus | neuroglian | 0.0014 | 0.0129 | 0.0057 |
Loa Loa (eye worm) | cytochrome b | 0.0517 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0018 | 0.0201 | 0.0129 |
Schistosoma mansoni | cytochrome b | 0.0517 | 1 | 1 |
Loa Loa (eye worm) | TK/KIN16 protein kinase | 0.0183 | 0.3439 | 0.3391 |
Echinococcus granulosus | roundabout 2 | 0.0018 | 0.0201 | 0.0129 |
Loa Loa (eye worm) | hypothetical protein | 0.0018 | 0.0201 | 0.0129 |
Schistosoma mansoni | cell adhesion molecule | 0.0015 | 0.0144 | 0.0144 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 25 nM | Inhibition of VEGFR2 | ChEMBL. | 21316232 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.