Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Candida albicans | beta-1,3-glucan synthase similar to S. cerevisiae GSC2 (YGR032W) and FKS1 (YLR342W) beta-1,3-glucan synthase | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | aldehyde dehydrogenase, mitochondrial | 0.0188 | 0.308 | 1 |
Echinococcus granulosus | geminin | 0.0182 | 0.2928 | 0.9505 |
Schistosoma mansoni | hypothetical protein | 0.0182 | 0.2928 | 0.9497 |
Schistosoma mansoni | hypothetical protein | 0.0182 | 0.2928 | 0.9497 |
Echinococcus multilocularis | geminin | 0.0182 | 0.2928 | 0.9497 |
Trichomonas vaginalis | set domain proteins, putative | 0.048 | 1 | 0.5 |
Toxoplasma gondii | aldehyde dehydrogenase | 0.0188 | 0.308 | 0.6533 |
Plasmodium vivax | SET domain protein, putative | 0.0061 | 0.0053 | 0.5 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0188 | 0.308 | 0.5 |
Brugia malayi | Pre-SET motif family protein | 0.0422 | 0.8618 | 1 |
Toxoplasma gondii | 1,3-beta-glucan synthase component protein | 0.0256 | 0.4687 | 1 |
Mycobacterium tuberculosis | Probable aldehyde dehydrogenase | 0.0188 | 0.308 | 0.5 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0188 | 0.308 | 0.5 |
Loa Loa (eye worm) | pre-SET domain-containing protein family protein | 0.0422 | 0.8618 | 1 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.0188 | 0.308 | 1 |
Echinococcus granulosus | aldehyde dehydrogenase mitochondrial | 0.0188 | 0.308 | 1 |
Leishmania major | aldehyde dehydrogenase, mitochondrial precursor | 0.0188 | 0.308 | 0.5 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.0188 | 0.308 | 1 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0188 | 0.308 | 0.5 |
Echinococcus granulosus | histone lysine methyltransferase setb | 0.0061 | 0.0053 | 0.0171 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.