Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | chemokine (C-X-C motif) receptor 3 | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trichomonas vaginalis | hypothetical protein | 0.0764 | 1 | 0.5 |
Trypanosoma cruzi | oxidoreductase-like protein, putative | 0.0052 | 0 | 0.5 |
Trypanosoma cruzi | beta-ketoacyl-ACP reductase | 0.0052 | 0 | 0.5 |
Brugia malayi | oxidoreductase, short chain dehydrogenase/reductase family protein | 0.0052 | 0 | 0.5 |
Schistosoma mansoni | dihydropteridine reductase | 0.0052 | 0 | 0.5 |
Entamoeba histolytica | 3-oxoacyl-(acyl-carrier protein) reductase, putative | 0.0052 | 0 | 0.5 |
Mycobacterium ulcerans | enoyl-(acyl carrier protein) reductase | 0.0764 | 1 | 1 |
Trypanosoma brucei | pteridine reductase 1 | 0.0052 | 0 | 0.5 |
Toxoplasma gondii | enoyl-acyl carrier reductase ENR | 0.0764 | 1 | 1 |
Onchocerca volvulus | 0.0052 | 0 | 0.5 | |
Loa Loa (eye worm) | oxidoreductase | 0.0052 | 0 | 0.5 |
Leishmania major | dehydrogenase/oxidoreductase-like protein | 0.0052 | 0 | 0.5 |
Trypanosoma cruzi | beta-ketoacyl-ACP reductase | 0.0052 | 0 | 0.5 |
Echinococcus multilocularis | 3 oxoacyl acyl carrier protein reductase | 0.0052 | 0 | 0.5 |
Schistosoma mansoni | 3-oxoacyl-[ACP] reductase | 0.0052 | 0 | 0.5 |
Trypanosoma brucei | oxidoreductase-like protein | 0.0052 | 0 | 0.5 |
Mycobacterium tuberculosis | NADH-dependent enoyl-[acyl-carrier-protein] reductase InhA (NADH-dependent enoyl-ACP reductase) | 0.0764 | 1 | 1 |
Trypanosoma brucei | beta-ketoacyl-ACP reductase | 0.0052 | 0 | 0.5 |
Plasmodium vivax | enoyl-acyl carrier protein reductase | 0.0764 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0052 | 0 | 0.5 |
Plasmodium falciparum | enoyl-acyl carrier reductase | 0.0764 | 1 | 1 |
Mycobacterium leprae | NADH-DEPENDENT ENOYL-[ACYL-CARRIER-PROTEIN] REDUCTASE INHA (NADH-DEPENDENT ENOYL-ACP REDUCTASE) | 0.0764 | 1 | 1 |
Leishmania major | 3-oxoacyl-ACP reductase, putative | 0.0052 | 0 | 0.5 |
Leishmania major | oxidoreductase-like protein | 0.0052 | 0 | 0.5 |
Onchocerca volvulus | 0.0052 | 0 | 0.5 | |
Loa Loa (eye worm) | retinol dehydrogenase 12 | 0.0052 | 0 | 0.5 |
Leishmania major | pteridine reductase 1 | 0.0052 | 0 | 0.5 |
Echinococcus granulosus | 3 oxoacyl acyl carrier protein reductase | 0.0052 | 0 | 0.5 |
Brugia malayi | oxidoreductase, short chain dehydrogenase/reductase family protein | 0.0052 | 0 | 0.5 |
Loa Loa (eye worm) | 3-hydroxyacyl-CoA dehydrogenase type II | 0.0052 | 0 | 0.5 |
Wolbachia endosymbiont of Brugia malayi | enoyl-ACP reductase | 0.0764 | 1 | 1 |
Leishmania major | dehydrogenase/oxidoreductase-like protein | 0.0052 | 0 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | = 3 nM | Antagonist activity at human CXCR3 | ChEMBL. | 21277198 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.