Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | glutathione reductase | 0.0044 | 0.2628 | 0.2669 |
Trichomonas vaginalis | mercuric reductase, putative | 0.0015 | 0.044 | 0.5 |
Mycobacterium tuberculosis | Probable membrane NADH dehydrogenase NdhA | 0.01 | 0.6916 | 0.8837 |
Mycobacterium ulcerans | dihydrolipoamide dehydrogenase, LpdB | 0.0015 | 0.044 | 0.5 |
Echinococcus granulosus | dihydrolipoamide dehydrogenase | 0.0015 | 0.044 | 0.0627 |
Brugia malayi | glutathione reductase | 0.0044 | 0.2628 | 0.2669 |
Mycobacterium tuberculosis | Probable dehydrogenase | 0.01 | 0.6916 | 0.8837 |
Mycobacterium tuberculosis | NAD(P)H quinone reductase LpdA | 0.0111 | 0.7768 | 1 |
Plasmodium falciparum | thioredoxin reductase | 0.0044 | 0.2628 | 1 |
Plasmodium vivax | thioredoxin reductase, putative | 0.0044 | 0.2628 | 1 |
Echinococcus multilocularis | dihydrolipoamide dehydrogenase | 0.0015 | 0.044 | 0.0627 |
Schistosoma mansoni | dihydrolipoamide dehydrogenase | 0.0015 | 0.044 | 0.044 |
Trypanosoma cruzi | trypanothione reductase, putative | 0.0044 | 0.2628 | 1 |
Mycobacterium tuberculosis | Probable reductase | 0.01 | 0.6916 | 0.8837 |
Chlamydia trachomatis | dihydrolipoyl dehydrogenase | 0.0015 | 0.044 | 0.5 |
Mycobacterium tuberculosis | Probable NADH dehydrogenase Ndh | 0.01 | 0.6916 | 0.8837 |
Mycobacterium tuberculosis | Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras | 0.0111 | 0.7768 | 1 |
Wolbachia endosymbiont of Brugia malayi | dihydrolipoamide dehydrogenase E3 component | 0.0015 | 0.044 | 0.5 |
Plasmodium falciparum | glutathione reductase | 0.0044 | 0.2628 | 1 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0101 | 0.7023 | 1 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0101 | 0.7023 | 0.7023 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0101 | 0.7023 | 0.7134 |
Mycobacterium tuberculosis | Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB | 0.01 | 0.6916 | 0.8837 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0138 | 0.9844 | 1 |
Mycobacterium tuberculosis | Putative ferredoxin reductase | 0.01 | 0.6916 | 0.8837 |
Mycobacterium tuberculosis | NADPH-dependent mycothiol reductase Mtr | 0.0044 | 0.2628 | 0.2985 |
Toxoplasma gondii | thioredoxin reductase | 0.0044 | 0.2628 | 1 |
Mycobacterium ulcerans | dihydrolipoamide dehydrogenase | 0.0015 | 0.044 | 0.5 |
Mycobacterium tuberculosis | Probable oxidoreductase | 0.0111 | 0.7768 | 1 |
Trichomonas vaginalis | glutathione reductase, putative | 0.0015 | 0.044 | 0.5 |
Mycobacterium leprae | DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE | 0.0111 | 0.7768 | 1 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0101 | 0.7023 | 1 |
Brugia malayi | MH2 domain containing protein | 0.0138 | 0.9844 | 1 |
Plasmodium vivax | glutathione reductase, putative | 0.0044 | 0.2628 | 1 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0138 | 0.9844 | 1 |
Loa Loa (eye worm) | thioredoxin reductase | 0.0044 | 0.2628 | 0.2669 |
Wolbachia endosymbiont of Brugia malayi | dihydrolipoamide dehydrogenase E3 component | 0.0015 | 0.044 | 0.5 |
Echinococcus multilocularis | thioredoxin glutathione reductase | 0.0044 | 0.2672 | 0.3805 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0101 | 0.7023 | 1 |
Brugia malayi | dihydrolipoyl dehydrogenase, mitochondrial precursor, putative | 0.0015 | 0.044 | 0.0447 |
Leishmania major | trypanothione reductase | 0.0044 | 0.2628 | 1 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0101 | 0.7023 | 0.7023 |
Trypanosoma brucei | trypanothione reductase | 0.0044 | 0.2628 | 1 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0101 | 0.7023 | 1 |
Echinococcus granulosus | thioredoxin glutathione reductase | 0.0044 | 0.2672 | 0.3805 |
Brugia malayi | Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein | 0.0011 | 0.0132 | 0.0134 |
Brugia malayi | Thioredoxin reductase | 0.0044 | 0.2628 | 0.2669 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0101 | 0.7023 | 0.7134 |
Brugia malayi | alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase | 0.0011 | 0.0132 | 0.0134 |
Mycobacterium ulcerans | flavoprotein disulfide reductase | 0.0015 | 0.044 | 0.5 |
Giardia lamblia | NADH oxidase lateral transfer candidate | 0.0015 | 0.044 | 0.5 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0101 | 0.7023 | 0.7023 |
Treponema pallidum | NADH oxidase | 0.0015 | 0.044 | 0.5 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.