Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Treponema pallidum | licC protein (licC) | 0.0625 | 0 | 0.5 |
Mycobacterium ulcerans | bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase | 0.341 | 1 | 1 |
Wolbachia endosymbiont of Brugia malayi | N-acetylglucosamine-1-phosphate uridyltransferase | 0.341 | 1 | 0.5 |
Toxoplasma gondii | eukaryotic initiation factor-2B, gamma subunit, putative | 0.0625 | 0 | 0.5 |
Mycobacterium tuberculosis | Probable UDP-N-acetylglucosamine pyrophosphorylase GlmU | 0.341 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
ED50 (functional) | > 10 mg kg-1 | Inhibition of antigen-induced bronchoconstriction in anesthetized guinea pig at 3 mg/kg intravenous dose | ChEMBL. | 8709099 |
Heart rate (functional) | = 1 beats min-1 | Change in heart rate in guinea pigs after 3 mg/kg intravenous dose | ChEMBL. | 8709099 |
IC50 (binding) | = 0.3 uM | Inhibition in vitro of Phosphodiesterase 4 activity isolated from guinea pig lung | ChEMBL. | 8709099 |
IC50 (binding) | = 4 uM | Inhibition in vitro of Phosphodiesterase 5 isolated from guinea pig lung | ChEMBL. | 8709099 |
IC50 (binding) | = 20 uM | Inhibition in vitro of Phosphodiesterase 5 isolated from guinea pig lung | ChEMBL. | 8709099 |
IC50 (binding) | = 20 uM | Inhibition in vitro of Phosphodiesterase 4 activity isolated from guinea pig lung | ChEMBL. | 8709099 |
IC50 (binding) | = 30 uM | Inhibition in vitro of Phosphodiesterase 3 isolated from guinea pig cardiac ventricle | ChEMBL. | 8709099 |
IC50 (binding) | = 80 uM | Inhibition in vitro of Phosphodiesterase 3 isolated from guinea pig cardiac ventricle | ChEMBL. | 8709099 |
IC50 (binding) | > 100 uM | Inhibition in vitro of Phosphodiesterase 1 isolated from guinea pig cardiac ventricle | ChEMBL. | 8709099 |
Ratio (binding) | = 4 | Selectivity as ratio of IC50 against PDE III to IC50 against PDE IV from guinea pig | ChEMBL. | 8709099 |
Ratio (binding) | = 100 | Selectivity as ratio of IC50 against PDE III to IC50 against PDE IV from guinea pig | ChEMBL. | 8709099 |
Reduction (functional) | = 79 % | Reduced histamine-induced bronchoconstriction in anesthetized guinea pig at 3 mg/kg intravenous dose | ChEMBL. | 8709099 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.