Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | phosphodiesterase 3A, cGMP-inhibited | Starlite/ChEMBL | References |
Homo sapiens | phosphodiesterase 3B, cGMP-inhibited | References |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | Get druggable targets OG5_132613 | All targets in OG5_132613 |
Brugia malayi | 3'5'-cyclic nucleotide phosphodiesterase family protein | Get druggable targets OG5_132613 | All targets in OG5_132613 |
Loa Loa (eye worm) | hypothetical protein | Get druggable targets OG5_132613 | All targets in OG5_132613 |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Toxoplasma gondii | eukaryotic initiation factor-2B, gamma subunit, putative | 0.0317 | 0.1149 | 0.5 |
Trichomonas vaginalis | NAD(P)H dehydrogenase, putative | 0.0179 | 0.0279 | 1 |
Giardia lamblia | NADPH oxidoreductase, putative | 0.0179 | 0.0279 | 0.5 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0179 | 0.0279 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0179 | 0.0279 | 1 |
Trichomonas vaginalis | NAD(P)H dehydrogenase, putative | 0.0179 | 0.0279 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.1027 | 0.5596 | 1 |
Brugia malayi | 3'5'-cyclic nucleotide phosphodiesterase family protein | 0.1027 | 0.5596 | 0.5 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0179 | 0.0279 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0179 | 0.0279 | 1 |
Wolbachia endosymbiont of Brugia malayi | N-acetylglucosamine-1-phosphate uridyltransferase | 0.173 | 1 | 0.5 |
Giardia lamblia | NADPH oxidoreductase, putative | 0.0179 | 0.0279 | 0.5 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0179 | 0.0279 | 1 |
Treponema pallidum | licC protein (licC) | 0.0317 | 0.1149 | 0.5 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0179 | 0.0279 | 1 |
Mycobacterium ulcerans | bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase | 0.173 | 1 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0179 | 0.0279 | 1 |
Trichomonas vaginalis | NAD(P)H dehydrogenase, putative | 0.0179 | 0.0279 | 1 |
Mycobacterium tuberculosis | Probable UDP-N-acetylglucosamine pyrophosphorylase GlmU | 0.173 | 1 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0179 | 0.0279 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0179 | 0.0279 | 1 |
Giardia lamblia | NADPH oxidoreductase, putative | 0.0179 | 0.0279 | 0.5 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0179 | 0.0279 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0179 | 0.0279 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0179 | 0.0279 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0179 | 0.0279 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (ADMET) | = 21.7 % | % metabolized in monkey S-9 after 2 hours (10 ug/ml) | ChEMBL. | 8230115 |
Activity (ADMET) | = 40.6 % | % metabolized in monkey S-9 after 2 hours (1 ug/ml) | ChEMBL. | 8230115 |
EC50 (functional) | = 0.51 uM | Inhibition of ADP-induced aggregation of human platelets | ChEMBL. | 1321911 |
EC50 (functional) | = 0.51 uM | Inhibition of ADP-induced aggregation of human platelets | ChEMBL. | 1321911 |
IC50 (binding) | = 0.4 nM | Inhibition of human platelet c-AMP phosphodiesterase PDE 3 | ChEMBL. | 1321911 |
IC50 (binding) | = 0.4 nM | Inhibition of human platelet c-AMP phosphodiesterase PDE 3 | ChEMBL. | 1321911 |
IC50 (functional) | = 0.1 uM | Inhibition of ADP induced aggregation of human platelets after 15 min of incubation of the drug with PRP prior to the addition of ADP | ChEMBL. | 1321911 |
IC50 (functional) | = 0.1 uM | Inhibition of ADP induced aggregation of human platelets after 15 min of incubation of the drug with PRP prior to the addition of ADP | ChEMBL. | 1321911 |
Inhibition (functional) | = 72 % | Inhibition of laser induced thrombus formation in microvasculature of rabbit ear chamber at a peroral dose of 0.1 mg/kg | ChEMBL. | 1321911 |
S | > 10 mg ml-1 | Aqueous solubility | ChEMBL. | 1321911 |
T1/2 (ADMET) | = 144 min | half-life (t1/2 min) | ChEMBL. | 8230115 |
T1/2 (ADMET) | = 333 min | half-life (t1/2 min) | ChEMBL. | 8230115 |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Homo sapiens | ChEMBL23 | 1321911 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
2 literature references were collected for this gene.