Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | dopamine receptor D4 | Starlite/ChEMBL | References |
Homo sapiens | dopamine receptor D2 | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | acetylcholinesterase | 0.5706 | 1 | 1 |
Mycobacterium tuberculosis | Carboxylesterase LipT | 0.0964 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.5706 | 1 | 1 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0964 | 0 | 0.5 |
Onchocerca volvulus | 0.0964 | 0 | 0.5 | |
Onchocerca volvulus | 0.0964 | 0 | 0.5 | |
Schistosoma mansoni | memapsin-2 (A01 family) | 0.3213 | 0.4743 | 0.4743 |
Echinococcus multilocularis | acetylcholinesterase | 0.5706 | 1 | 1 |
Trichomonas vaginalis | spcc417.12 protein, putative | 0.0964 | 0 | 0.5 |
Onchocerca volvulus | 0.0964 | 0 | 0.5 | |
Onchocerca volvulus | 0.0964 | 0 | 0.5 | |
Echinococcus granulosus | carboxylesterase 5A | 0.5706 | 1 | 1 |
Onchocerca volvulus | 0.0964 | 0 | 0.5 | |
Echinococcus granulosus | acetylcholinesterase | 0.5706 | 1 | 1 |
Mycobacterium ulcerans | carboxylesterase, LipT | 0.0964 | 0 | 0.5 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.5706 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.5706 | 1 | 1 |
Brugia malayi | Carboxylesterase family protein | 0.5706 | 1 | 1 |
Echinococcus multilocularis | carboxylesterase 5A | 0.5706 | 1 | 1 |
Echinococcus multilocularis | acetylcholinesterase | 0.5706 | 1 | 1 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0964 | 0 | 0.5 |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.5706 | 1 | 1 |
Trichomonas vaginalis | carboxylesterase domain containing protein, putative | 0.0964 | 0 | 0.5 |
Loa Loa (eye worm) | carboxylesterase | 0.5706 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Ki (binding) | = 84 nM | Ability to displace [3H]-spiperone from cloned human Dopamine receptor D4 expressed in CHO K-1 cells in vitro | ChEMBL. | 9276014 |
Ki (binding) | = 84 nM | Ability to displace [3H]-spiperone from cloned human Dopamine receptor D4 expressed in CHO K-1 cells in vitro | ChEMBL. | 9276014 |
Ki (binding) | > 5800 nM | Ability to displace [3H]-spiperone from human cloned Dopamine receptor D2 expressed in CHO K-1 cells in vitro. | ChEMBL. | 9276014 |
Ki (binding) | > 5800 nM | Ability to displace [3H]-spiperone from human cloned Dopamine receptor D2 expressed in CHO K-1 cells in vitro. | ChEMBL. | 9276014 |
Ki ratio (binding) | = 69 | Relative binding to dopamine D2 and D4 receptor, ratio of Ki | ChEMBL. | 9276014 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.