Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | metabotropic glutamate receptor 2 3 (mglur group 2) | 0.009 | 0.0322 | 0.0516 |
Loa Loa (eye worm) | hypothetical protein | 0.0098 | 0.0423 | 1 |
Echinococcus multilocularis | metabotropic glutamate receptor 5 | 0.0098 | 0.0423 | 0.0423 |
Schistosoma mansoni | hypothetical protein | 0.0182 | 0.1569 | 0.2516 |
Plasmodium falciparum | sortilin | 0.0744 | 0.9175 | 0.5 |
Echinococcus granulosus | sortilin | 0.0744 | 0.9175 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0217 | 0.2039 | 0.327 |
Schistosoma mansoni | sortilin | 0.0527 | 0.6236 | 1 |
Plasmodium vivax | sortilin, putative | 0.0744 | 0.9175 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0182 | 0.1569 | 0.2516 |
Echinococcus multilocularis | sortilin | 0.0744 | 0.9175 | 0.9175 |
Toxoplasma gondii | sortilin, putative | 0.0744 | 0.9175 | 0.5 |
Echinococcus granulosus | metabotropic glutamate receptor 5 | 0.0098 | 0.0423 | 0.0461 |
Brugia malayi | Metabotropic glutamate receptor precursor. | 0.0079 | 0.0174 | 1 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.