Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Entamoeba histolytica | phosphatidylinositol 3-kinase, putative | phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha | 1068 aa | 927 aa | 29.0 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trichomonas vaginalis | phopsphatidylinositol 3-kinase, drosophila, putative | 0.0118 | 0.4304 | 1 |
Brugia malayi | alpha1,3-fucosyltransferase homologue | 0.0111 | 0.3927 | 0.9126 |
Brugia malayi | phosphoinositide 3'-hydroxykinase p110-alpha subunit, putative | 0.0104 | 0.3533 | 0.8209 |
Trypanosoma cruzi | phosphatidylinositol 3-kinase 2, putative | 0.0118 | 0.4304 | 1 |
Schistosoma mansoni | alpha(13)fucosyltransferase | 0.0111 | 0.3927 | 0.3927 |
Brugia malayi | Phosphatidylinositol 3- and 4-kinase family protein | 0.0077 | 0.2025 | 0.4706 |
Loa Loa (eye worm) | fucosyl transferase | 0.0111 | 0.3927 | 0.4452 |
Echinococcus multilocularis | phosphatidylinositol 4 phosphate 3 kinase C2 | 0.0077 | 0.2025 | 0.1674 |
Trichomonas vaginalis | phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative | 0.0081 | 0.2278 | 0.5294 |
Onchocerca volvulus | Alpha 1,3 fucosyltransferase homolog | 0.0047 | 0.0422 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0111 | 0.3927 | 0.4452 |
Giardia lamblia | Phosphoinositide-3-kinase, catalytic, alpha polypeptide | 0.0057 | 0.0958 | 0.5 |
Schistosoma mansoni | alpha 13/4 fucosyltransferase Lewis 1 | 0.0064 | 0.1342 | 0.1342 |
Entamoeba histolytica | phosphatidylinositol 3-kinase, putative | 0.0052 | 0.0704 | 0.1637 |
Loa Loa (eye worm) | hypothetical protein | 0.0047 | 0.0422 | 0.0359 |
Loa Loa (eye worm) | hypothetical protein | 0.0077 | 0.2025 | 0.223 |
Entamoeba histolytica | hypothetical protein | 0.0094 | 0.2983 | 0.6931 |
Schistosoma mansoni | alpha(13)fucosyltransferase | 0.0111 | 0.3927 | 0.3927 |
Trichomonas vaginalis | phosphatidylinositol 3-kinase catalytic subunit gamma, putative | 0.0118 | 0.4304 | 1 |
Trichomonas vaginalis | phosphatidylinositol 3-kinase class, putative | 0.0081 | 0.2278 | 0.5294 |
Echinococcus granulosus | phosphatidylinositol 4 phosphate 3 kinase C2 | 0.0077 | 0.2025 | 0.1674 |
Entamoeba histolytica | phosphatidylinositol 3-kinase, putative | 0.0118 | 0.4304 | 1 |
Loa Loa (eye worm) | phosphatidylinositol 3 | 0.0198 | 0.8679 | 1 |
Trichomonas vaginalis | phosphatidylinositol kinase, putative | 0.0118 | 0.4304 | 1 |
Schistosoma mansoni | alpha(13)fucosyltransferase | 0.0111 | 0.3927 | 0.3927 |
Entamoeba histolytica | phosphatidylinositol 3-kinase, putative | 0.0094 | 0.2983 | 0.6931 |
Schistosoma mansoni | alpha(13)fucosyltransferase | 0.0111 | 0.3927 | 0.3927 |
Brugia malayi | Phosphatidylinositol 3- and 4-kinase family protein | 0.0118 | 0.4304 | 1 |
Schistosoma mansoni | alpha(13)fucosyltransferase | 0.0111 | 0.3927 | 0.3927 |
Entamoeba histolytica | phosphatidylinositol 3-kinase 1, putative | 0.0115 | 0.4112 | 0.9555 |
Trypanosoma cruzi | phosphatidylinositol 3-kinase 2, putative | 0.0118 | 0.4304 | 1 |
Brugia malayi | Fucosyl transferase family protein | 0.0111 | 0.3927 | 0.9126 |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Homo sapiens | ChEMBL23 | 24900252 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.