Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | insulin growth factor 1 receptor beta | 0.0860596 | 0.979841 | 1 |
Schistosoma mansoni | tyrosine kinase | 0.0379382 | 0.350876 | 0.34412 |
Echinococcus multilocularis | fibroblast growth factor receptor 4 | 0.0674939 | 0.737181 | 0.752347 |
Schistosoma mansoni | tyrosine kinase | 0.0379382 | 0.350876 | 0.34412 |
Trypanosoma brucei | dihydrofolate reductase-thymidylate synthase | 0.0320125 | 0.273426 | 0.5 |
Brugia malayi | Protein kinase domain containing protein | 0.0481214 | 0.483974 | 0.391315 |
Echinococcus granulosus | thymidylate synthase | 0.0227399 | 0.152229 | 0.136972 |
Loa Loa (eye worm) | hypothetical protein | 0.0159267 | 0.0631781 | 0.0432017 |
Echinococcus granulosus | epidermal growth factor receptor | 0.0397748 | 0.374882 | 0.369152 |
Echinococcus multilocularis | insulin receptor | 0.0860596 | 0.979841 | 1 |
Echinococcus multilocularis | epidermal growth factor receptor | 0.0397748 | 0.374882 | 0.382594 |
Onchocerca volvulus | Tyrosine kinase homolog | 0.0781478 | 0.876431 | 1 |
Schistosoma mansoni | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0227399 | 0.152229 | 0.136972 |
Schistosoma mansoni | tyrosine kinase | 0.0860596 | 0.979841 | 1 |
Schistosoma mansoni | tyrosine kinase | 0.0674939 | 0.737181 | 0.746955 |
Schistosoma mansoni | nephrin | 0.0143207 | 0.0421866 | 0.02222 |
Loa Loa (eye worm) | hypothetical protein | 0.0159267 | 0.0631781 | 0.0432017 |
Echinococcus granulosus | twitchin | 0.0143207 | 0.0421866 | 0.02222 |
Brugia malayi | Furin-like cysteine rich region family protein | 0.0397748 | 0.374882 | 0.262633 |
Schistosoma mansoni | tyrosine kinase | 0.0379382 | 0.350876 | 0.34412 |
Echinococcus multilocularis | thymidylate synthase | 0.0227399 | 0.152229 | 0.155361 |
Schistosoma mansoni | tyrosine kinase | 0.0397748 | 0.374882 | 0.369152 |
Mycobacterium tuberculosis | Probable thymidylate synthase ThyA (ts) (TSASE) | 0.0227399 | 0.152229 | 0.5 |
Echinococcus granulosus | fibroblast growth factor receptor 4 | 0.0674939 | 0.737181 | 0.746955 |
Loa Loa (eye worm) | TK/EGFR protein kinase | 0.0397748 | 0.374882 | 0.361552 |
Schistosoma mansoni | tyrosine kinase | 0.0860596 | 0.979841 | 1 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase | 0.0320125 | 0.273426 | 0.5 |
Echinococcus multilocularis | epidermal growth factor receptor | 0.0397748 | 0.374882 | 0.382594 |
Toxoplasma gondii | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0320125 | 0.273426 | 0.5 |
Loa Loa (eye worm) | TK/KIN16 protein kinase | 0.0876019 | 1 | 1 |
Echinococcus granulosus | basic fibroblast growth factor receptor 1 A | 0.0674939 | 0.737181 | 0.746955 |
Plasmodium falciparum | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0320125 | 0.273426 | 0.5 |
Echinococcus granulosus | insulin receptor | 0.0860596 | 0.979841 | 1 |
Loa Loa (eye worm) | TK/INSR protein kinase | 0.0860596 | 0.979841 | 0.979411 |
Mycobacterium leprae | PROBABLE THYMIDYLATE SYNTHASE THYA (TS) (TSASE) | 0.0227399 | 0.152229 | 0.5 |
Leishmania major | dihydrofolate reductase-thymidylate synthase | 0.0320125 | 0.273426 | 0.5 |
Echinococcus granulosus | melanoma receptor tyrosine protein kinase | 0.0397748 | 0.374882 | 0.369152 |
Brugia malayi | Immunoglobulin I-set domain containing protein | 0.0876019 | 1 | 1 |
Echinococcus multilocularis | basic fibroblast growth factor receptor 1 A | 0.0674939 | 0.737181 | 0.752347 |
Loa Loa (eye worm) | hypothetical protein | 0.0462847 | 0.459969 | 0.448454 |
Loa Loa (eye worm) | TK protein kinase | 0.0707302 | 0.779481 | 0.774778 |
Loa Loa (eye worm) | thymidylate synthase | 0.0227399 | 0.152229 | 0.134152 |
Echinococcus multilocularis | roundabout 2 | 0.0159267 | 0.0631781 | 0.0644779 |
Onchocerca volvulus | 0.0730748 | 0.810126 | 0.908444 | |
Mycobacterium ulcerans | thymidylate synthase | 0.0227399 | 0.152229 | 0.5 |
Echinococcus granulosus | neuroglian | 0.0143207 | 0.0421866 | 0.02222 |
Echinococcus multilocularis | insulin growth factor 1 receptor beta | 0.0860596 | 0.979841 | 1 |
Plasmodium vivax | bifunctional dihydrofolate reductase-thymidylate synthase, putative | 0.0320125 | 0.273426 | 0.5 |
Schistosoma mansoni | tyrosine kinase | 0.0397748 | 0.374882 | 0.369152 |
Echinococcus granulosus | epidermal growth factor receptor | 0.0397748 | 0.374882 | 0.369152 |
Brugia malayi | Protein kinase domain containing protein | 0.0860596 | 0.979841 | 0.976221 |
Echinococcus multilocularis | neuroglian | 0.0143207 | 0.0421866 | 0.0430545 |
Brugia malayi | Immunoglobulin I-set domain containing protein | 0.0707302 | 0.779481 | 0.739883 |
Schistosoma mansoni | tyrosine kinase | 0.0397748 | 0.374882 | 0.369152 |
Echinococcus granulosus | roundabout 2 | 0.0159267 | 0.0631781 | 0.0441098 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | = 18.85 nM | Antimalarial activity against chloroquine-resistant Plasmodium falciparum 3D7 infected in erythrocytes after 72 hrs by syber green 1 assay | ChEMBL. | 21194812 |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Plasmodium falciparum | ChEMBL23 | 21194812 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.