Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trichomonas vaginalis | Sentrin-specific protease, putative | 0.0111 | 0.1933 | 0.5 |
Trichomonas vaginalis | Clan CE, family C48, Ulp1-like cysteine peptidase | 0.0111 | 0.1933 | 0.5 |
Echinococcus multilocularis | caspase | 0.012 | 0.2633 | 0.2633 |
Trypanosoma cruzi | hypothetical protein | 0.0111 | 0.1933 | 0.5 |
Schistosoma mansoni | caspase-3 (C14 family) | 0.012 | 0.2633 | 0.0868 |
Echinococcus multilocularis | caspase 3, apoptosis cysteine peptidase | 0.012 | 0.2633 | 0.2633 |
Echinococcus multilocularis | expressed conserved protein | 0.0163 | 0.616 | 0.616 |
Trichomonas vaginalis | Clan CE, family C48, Ulp1-like cysteine peptidase | 0.0111 | 0.1933 | 0.5 |
Echinococcus granulosus | expressed conserved protein | 0.0163 | 0.616 | 0.616 |
Schistosoma mansoni | caspase-7 (C14 family) | 0.012 | 0.2633 | 0.0868 |
Echinococcus granulosus | caspase 3 apoptosis cysteine peptidase | 0.012 | 0.2633 | 0.2633 |
Echinococcus granulosus | caspase | 0.012 | 0.2633 | 0.2633 |
Brugia malayi | Ulp1 protease family, C-terminal catalytic domain containing protein | 0.0111 | 0.1933 | 0.5 |
Echinococcus multilocularis | sentrin specific protease 8 | 0.0111 | 0.1933 | 0.1933 |
Echinococcus granulosus | sentrin specific protease 8 | 0.0111 | 0.1933 | 0.1933 |
Trichomonas vaginalis | Clan CE, family C48, Ulp1-like cysteine peptidase | 0.0111 | 0.1933 | 0.5 |
Loa Loa (eye worm) | Ulp1 protease | 0.0111 | 0.1933 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
EC50 (functional) | > 30 uM | Activation of UTRN promoter in mouse H2K cells assessed as upregulation of UTRN production after 48 hrs by luciferase reporter linked assay | ChEMBL. | 21456623 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.