Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hexokinase | 0.0397 | 0.4604 | 0.4604 |
Brugia malayi | Hexokinase family protein | 0.0397 | 0.4604 | 0.4604 |
Loa Loa (eye worm) | hypothetical protein | 0.0201 | 0.0123 | 0.0123 |
Brugia malayi | hexokinase type II | 0.0201 | 0.0123 | 0.0123 |
Loa Loa (eye worm) | hypothetical protein | 0.0432 | 0.5396 | 0.5396 |
Loa Loa (eye worm) | hypothetical protein | 0.0201 | 0.0123 | 0.0123 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (binding) | = 64.54 nmol/min/mg | Activity at human recombinant N6-methyl-AMP deaminase assessed as reaction rate after 60 mins by HPLC analysis | ChEMBL. | 21429755 |
CC50 (ADMET) | > 278 uM | Cytotoxicity against human CEM cells assessed as inhibition of cell proliferation after 72 hrs by coulter counter analysis | ChEMBL. | 21429755 |
MCC (ADMET) | > 100 uM | Cytotoxicity against human CEM cells assessed as minimum concentration required for morphological alteration by microscopic analysis | ChEMBL. | 21429755 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.