Detailed view for Bm1_00150

Basic information

TDR Targets ID: 239187
Brugia malayi, hexokinase type II

Source Database / ID:  GenBank

pI: 6.6272 | Length (AA): 227 | MW (Da): 25156 | Paralog Number: 2891

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG2

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00349   Hexokinase

Gene Ontology

Mouse over links to read term descriptions.
GO:0016773   phosphotransferase activity, alcohol group as acceptor  
GO:0005536   glucose binding  
GO:0004396   hexokinase activity  
GO:0001678   cellular glucose homeostasis  
GO:0005524   ATP binding  
GO:0005975   carbohydrate metabolic process  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 3 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
5 227 1bg3 (A) 456 680 49.00 0 1 1.56878 -0.21
12 227 1bdg (A) 15 232 44.00 0 1 1.51244 -0.55
14 227 2nzt (A) 17 232 51.00 0 1 1.56533 -0.41

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

This protein does not belong to any OrthoMCL cluster.

Essentiality

No essentiality data collected for this gene and/or its orthologs.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.


Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets

Obtained from network model

Ranking Plot


Putative Drugs List


Compound Raw Global Species
0.0305 0.3101 0.3101
0.0395 0.292 0.292
0.0463 0.3128 0.3128
0.0273 0.2758 0.2758
0.0743 0.3111 0.3111
0.0411 0.2577 0.2577
0.0329 0.3103 0.3103
0.0656 0.3157 0.3156
0.0827 0.2725 0.3111
0.0031 0.2545 0.2545
0.0081 0.2517 0.1959
0.0422 0.3 0.3075
0.0866 0.3112 0.3112
0.0384 0.2595 0.2595
0.0059 0.2705 0.2705
0.0061 0.2717 0.2717
0.0055 0.2714 0.2714
0.0253 0.309 0.309
0.0269 0.2905 0.2871
0.0181 0.2768 0.2462
0.0703 0.3004 0.3004
0.0672 0.3096 0.3096
0.0274 0.31 0.31
0.0747 0.3037 0.3033
0.0158 0.271 0.0123
0.0523 0.3021 0.3021
0.0516 0.3131 0.3131
0.0656 0.2586 0.3137
0.0251 0.2892 0.2892
0.0213 0.2507 0.2507
0.0269 0.2905 0.2871
0.0248 0.2533 0.2533
0.0525 0.3142 0.3139
0.0676 0.3147 0.314
0.0186 0.2905 0.2905
0.0212 0.2804 0.2789
0.0657 0.2792 0.2792
0.0408 0.3021 0.3021
0.0835 0.3138 0.3138
0.0503 0.3132 0.3132
0.0333 0.299 0.2945
0.0255 0.2851 0.2851
0.0251 0.2933 0.3094
0.0503 0.3085 0.3085
0.0401 0.2993 0.2993
0.0202 0.2858 0.2858
0.0101 0.2655 0.2779
0.0401 0.2993 0.2993
0.025 0.2578 0.2578
0.0608 0.3135 0.3135
0.0252 0.3105 0.3097
0.0227 0.2816 0.2816
0.0246 0.3101 0.3101
0.0289 0.3086 0.3061
0.0369 0.2698 0.2698
0.0306 0.2542 0.2542
0.0363 0.3033 0.2937
0.0278 0.3043 0.3043
0.0423 0.2745 0.2745
0.0617 0.3028 0.3028
0.0131 0.2909 0.2909
0.0341 0.3052 0.3052
0.0191 0.2677 0.2677
0.0157 0.2741 0.2741
0.0515 0.2979 0.2979
0.0592 0.3045 0.3045
0.0198 0.3006 0.2964
0.0229 0.2561 0.3033
0.0569 0.3086 0.3086
0.02 0.2665 0.2463
0.0454 0.3069 0.3069
0.0291 0.3034 0.3034
0.0373 0.3084 0.3084
0.0475 0.3086 0.3046
0.0569 0.3086 0.3086
0.0441 0.3155 0.3153
0.0106 0.2803 0.2739
0.0403 0.3013 0.298
0.0481 0.3128 0.3128
0.0544 0.2741 0.3099
0.0513 0.2933 0.2933
0.0652 0.3139 0.3139
0.0101 0.2756 0.2742
0.0767 0.3144 0.3144
0.0343 0.3086 0.3086
0.0255 0.2638 0.2638
0.0773 0.3165 0.315
0.0256 0.2647 0.3092
0.0212 0.2804 0.2789
0.0052 0.2729 0.2729
0.0404 0.2951 0.2951
0.0246 0.3101 0.3101
0.0473 0.2901 0.2901
0.0401 0.3123 0.3123
0.049 0.3154 0.3154
0.0688 0.2968 0.2968
0.0306 0.2826 0.1977
0.0142 0.2886 0.2688
0.0257 0.3115 0.3092
0.0243 0.3056 0.3056
0.0171 0.293 0.293
0.0145 0.2618 0.2594
0.041 0.2669 0.2669
0.0447 0.2921 0.288
0.0537 0.3009 0.3009
0.0526 0.3059 0.3059
0.0516 0.3129 0.3118
0.0515 0.3014 0.3014
0.0254 0.2673 0.2673
0.0408 0.3103 0.3095
0.0715 0.3092 0.3092
0.0534 0.3008 0.3008
0.0255 0.2851 0.2851
0.0318 0.2934 0.2924
0.029 0.2937 0.2937
0.0257 0.3115 0.3092
0.0055 0.2717 0.2717
0.0384 0.311 0.307
0.0374 0.3085 0.3085
0.0171 0.293 0.293
0.0373 0.3084 0.3084
0.0182 0.265 0.265
0.0134 0.3046 0.3046
0.0945 0.2761 0.2034
0.018 0.2912 0.2817
0.0503 0.3132 0.3132
0.0252 0.3105 0.3097
0.032 0.2888 0.2888
0.0508 0.2988 0.2988
0.0503 0.3132 0.3132
0.0374 0.2999 0.2999
0.0289 0.2732 0.2732
0.0061 0.2717 0.2717
0.0565 0.3134 0.3134
0.0125 0.2736 0.2425
0.0327 0.2555 0.3115
0.0161 0.267 0.267
0.0646774 0.308018 0.307226
0.0157 0.2741 0.2741
0.0354 0.3109 0.3109
0.0382 0.2628 0.2628
0.0526 0.3149 0.3148
0.0057 0.2684 0.2684
0.0738 0.3142 0.3142
0.038 0.2825 0.2825
0.059 0.2974 0.2974
0.0241 0.2882 0.2882
0.0106 0.2803 0.2739
0.0424 0.3094 0.3094
0.0524 0.3093 0.305
0.0421 0.2815 0.2815
0.018 0.3059 0.3059
0.0248 0.2573 0.2573
0.0158 0.271 0.0123
0.0084 0.3031 0.3031
0.0541 0.2945 0.2945
0.018 0.2901 0.2901
0.0473 0.2867 0.2867
0.0396 0.3045 0.2958
0.0341 0.3135 0.3128
0.0103 0.2832 0.2832
0.0288 0.2862 0.2862
0.0133 0.2989 0.2989
0.0253 0.3042 0.3027
0.0246 0.3101 0.3101
0.0623 0.2982 0.2982
0.0257 0.3115 0.3092
0.0432 0.3102 0.3102
0.0684 0.31 0.31
0.0458 0.2979 0.2979
0.013 0.2876 0.2876
0.0396 0.2933 0.2933
0.0517 0.3095 0.3095
0.0619 0.2983 0.2983
0.199982 0.298 0.298
0.0061 0.2717 0.2717
0.0802 0.3147 0.3147
0.0156 0.2506 0.2506
0.0333 0.3021 0.3021
0.047 0.3021 0.3021
0.054 0.2985 0.2985
0.0176 0.2772 0.3051
0.0382 0.2628 0.2628
0.0377 0.3094 0.3094
0.0363 0.2908 0.2908
0.0161 0.2596 0.2521
0.051 0.287 0.287
0.0432 0.3102 0.3102
0.0171 0.293 0.293
0.0424 0.3104 0.3104
0.0262 0.2929 0.2861
0.0173 0.2953 0.2953
0.0327 0.2555 0.3115
0.0401 0.2993 0.2993
0.0326 0.3084 0.3082
0.0229 0.2561 0.3033
0.0622 0.2987 0.2987
0.0256 0.3063 0.3063
0.0228 0.3079 0.3079
0.0684 0.31 0.31
0.0421 0.2815 0.2815
0.0162 0.3089 0.3065
0.0425 0.3126 0.3126
0.0629 0.309 0.3087
0.0262 0.2716 0.2716
0.0456 0.2997 0.2997
0.0283 0.287 0.2842
0.0274 0.3002 0.3002
0.0445 0.3136 0.3136
0.0061 0.2717 0.2717
0.0161 0.2596 0.2521
0.0566 0.2905 0.2905
0.0189 0.2966 0.2966
0.0596 0.3137 0.3137
0.0438 0.3138 0.3138
0.0198 0.2793 0.2743
0.0664 0.3139 0.3139
0.0275 0.3117 0.3111
0.024 0.2797 0.0123
0.0367 0.2977 0.2977
0.0257 0.3115 0.3092
0.0273 0.3084 0.3084
0.0423 0.2745 0.2745
0.0354 0.308 0.3055
0.0257 0.2792 0.2792
0.0351 0.3069 0.3049
0.0617 0.3028 0.3028
0.0684 0.31 0.31
0.0538 0.2897 0.2897
0.1391 0.3081 0.3081
0.0237 0.2901 0.1711
0.0235 0.2843 0.283
0.0531 0.3033 0.3033
0.0518 0.2963 0.2963
0.0447 0.2921 0.288
0.0396 0.2912 0.2912
0.0631 0.3138 0.3138
0.0531 0.3033 0.3033
0.0289 0.2732 0.2732
0.0156 0.3018 0.3006
0.0245 0.306 0.3024
0.0606 0.3043 0.3043
0.0333 0.3127 0.3127
0.0624 0.3049 0.3029
0.0187 0.2971 0.2971
0.0279 0.2751 0.3028
0.2095 0.2938 0.2916
0.0373 0.3073 0.3029
0.0524 0.3093 0.305
0.0145 0.2908 0.2908
0.0418 0.288 0.288
0.0258 0.267 0.25
0.0466 0.2964 0.2964
0.0257 0.3009 0.3009
0.0591 0.3081 0.3081
0.0311 0.287 0.287
0.0466 0.3109 0.3109
0.0454 0.2749 0.2749
0.0259 0.2884 0.2957
0.0061 0.2717 0.2717
0.0327 0.2555 0.3115
0.038 0.3055 0.3012
0.033 0.2898 0.2898
0.0422 0.3 0.3075
0.0161 0.2885 0.2885
0.0404 0.3153 0.3122
0.0694 0.3014 0.3011
0.057 0.3133 0.3133
0.0213 0.2507 0.2507
0.0466 0.3109 0.3109
0.0297 0.3092 0.3064
0.0209 0.3007 0.3007
0.0109 0.2684 0.2876
0.0354 0.3109 0.3109
0.0061 0.2717 0.2717
0.0527 0.3108 0.3108
0.0077 0.2821 0.2819
0.0208 0.2579 0.2579
0.0432 0.3102 0.3102
0.0271 0.281 0.281
0.0089 0.2891 0.2813
0.0509 0.3025 0.3025
0.0669 0.2921 0.2921
0.0296 0.2832 0.2832
0.0269 0.2905 0.2871
0.0485 0.3128 0.3128
0.0393 0.299 0.299
0.0182 0.2804 0.2804
0.0527 0.3108 0.3108
0.0827 0.2725 0.3111
0.0249 0.3142 0.3086
0.0531 0.3098 0.3098
0.0408 0.3103 0.3095
0.0531 0.3033 0.3033
0.1391 0.3081 0.3081
0.0262 0.2716 0.2716
0.0402 0.3072 0.305
0.0334 0.3082 0.3081
0.0444 0.3125 0.3125
0.0527 0.3108 0.3108
0.0491 0.314 0.3123
0.0053 0.3168 0.3168
0.0086 0.3007 0.2962
0.0489 0.2921 0.2921
0.0301 0.3 0.3
0.0421 0.2815 0.2815
0.0503 0.3085 0.3085
0.0414 0.2663 0.2663
0.0454 0.3069 0.3069
0.026 0.3032 0.3032
0.0234 0.3093 0.3093
0.0338 0.2786 0.2359
0.0526 0.3109 0.3109
0.0318 0.2974 0.2959
0.0238 0.2616 0.2603
0.0432 0.3102 0.3102
0.0253 0.2998 0.302
0.0827 0.2725 0.3111
0.049 0.3112 0.3101
0.0421 0.2815 0.2815
0.0369 0.3095 0.3092
0.0387 0.2715 0.2715
0.026 0.3144 0.309
0.0257 0.3115 0.3092
0.0306 0.3025 0.297
0.0377 0.3094 0.3094
0.0361 0.2798 0.2798
0.0484 0.2969 0.2969
0.0453 0.2805 0.2805
0.0436 0.3119 0.3119
0.041 0.3077 0.3071
0.0434 0.2642 0.0123
0.0481 0.2872 0.2872
0.033 0.2898 0.2898
0.0234 0.2606 0.2957
0.0544 0.2741 0.3099
0.0171 0.293 0.293
0.0408 0.3077 0.3077
0.0257 0.3009 0.3009
0.047 0.3073 0.3073
0.0245 0.3062 0.3062
0.0257 0.3115 0.3092
0.0566 0.3152 0.315
0.0394 0.2912 0.2912
0.0274 0.2672 0.264
0.0059 0.2717 0.2717
0.0056 0.2818 0.2818
0.0446 0.2999 0.2999

Assayability

Assay information

  • Assay for Hexokinase (2.7.1.1 ) Sigma-Aldrich
  • Automatic link to known assays based on EC numbers.

Reagent availability

No reagent availability information for this target.

Bibliographic References

2 literature references were collected for this gene.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

No user comments are available for this gene. Log in to add comments, or register.

Enter your comment

User ()
Gene identifier Bm1_00150 (Brugia malayi), hexokinase type II
Title for this comment
Comment