Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | p21 activated protein kinase 1 Dpak1 | 0.0468 | 0.1325 | 0.1628 |
Loa Loa (eye worm) | hypothetical protein | 0.0462 | 0.1288 | 0.1288 |
Echinococcus multilocularis | serine:threonine protein kinase PAK 3 | 0.0468 | 0.1325 | 0.1628 |
Trichomonas vaginalis | STE family protein kinase | 0.0468 | 0.1325 | 1 |
Trichomonas vaginalis | STE family protein kinase | 0.0468 | 0.1325 | 1 |
Giardia lamblia | Kinase, STE STE20 | 0.0468 | 0.1325 | 0.5 |
Entamoeba histolytica | p21-activated kinase | 0.0468 | 0.1325 | 1 |
Trichomonas vaginalis | STE family protein kinase | 0.0468 | 0.1325 | 1 |
Echinococcus multilocularis | p21 activated protein kinase 1 Dpak1 | 0.0468 | 0.1325 | 0.1628 |
Trichomonas vaginalis | STE family protein kinase | 0.0468 | 0.1325 | 1 |
Entamoeba histolytica | protein kinase, putative | 0.0279 | 0.0037 | 0.0277 |
Echinococcus granulosus | serine:threonine protein kinase PAK 3 | 0.0468 | 0.1325 | 0.1628 |
Echinococcus granulosus | serine:threonine protein kinase PAK 4 | 0.1467 | 0.8137 | 1 |
Entamoeba histolytica | protein kinase, putative | 0.0468 | 0.1325 | 1 |
Brugia malayi | Protein kinase domain | 0.0468 | 0.1325 | 0.1325 |
Entamoeba histolytica | protein kinase, putative | 0.0279 | 0.0037 | 0.0277 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0462 | 0.1288 | 0.9715 |
Echinococcus multilocularis | PAK box P21 Rho binding | 0.0279 | 0.0037 | 0.0045 |
Echinococcus multilocularis | serine:threonine protein kinase PAK 4 | 0.1467 | 0.8137 | 1 |
Echinococcus multilocularis | serine:threonine protein kinase PAK 3 | 0.0468 | 0.1325 | 0.1628 |
Schistosoma mansoni | protein kinase | 0.0468 | 0.1325 | 1 |
Entamoeba histolytica | protein kinase, putative | 0.0279 | 0.0037 | 0.0277 |
Echinococcus granulosus | serine:threonine protein kinase PAK 3 | 0.0468 | 0.1325 | 0.1628 |
Schistosoma mansoni | protein kinase | 0.0279 | 0.0037 | 0.0277 |
Schistosoma mansoni | protein kinase | 0.0468 | 0.1325 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Inhibition (binding) | < 45 % | Inhibition of human ICMT at 10 uM incubated with N-Acetyl-S-farnesyl-L-cysteine substrate for 5 mins followed by addition of [14C]-SAM measured after 30 mins by liquid scintillation counting | ChEMBL. | 21334890 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.