Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | serine:threonine protein kinase PAK 4 | 0.0182 | 0.8137 | 1 |
Echinococcus multilocularis | PAK box P21 Rho binding | 0.0035 | 0.0037 | 0.0045 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0057 | 0.1288 | 0.9715 |
Brugia malayi | Protein kinase domain | 0.0058 | 0.1325 | 0.1325 |
Entamoeba histolytica | protein kinase, putative | 0.0035 | 0.0037 | 0.0277 |
Entamoeba histolytica | protein kinase, putative | 0.0058 | 0.1325 | 1 |
Echinococcus granulosus | serine:threonine protein kinase PAK 4 | 0.0182 | 0.8137 | 1 |
Echinococcus granulosus | serine:threonine protein kinase PAK 3 | 0.0058 | 0.1325 | 0.1628 |
Entamoeba histolytica | protein kinase, putative | 0.0035 | 0.0037 | 0.0277 |
Schistosoma mansoni | protein kinase | 0.0058 | 0.1325 | 1 |
Schistosoma mansoni | protein kinase | 0.0035 | 0.0037 | 0.0277 |
Echinococcus granulosus | serine:threonine protein kinase PAK 3 | 0.0058 | 0.1325 | 0.1628 |
Entamoeba histolytica | protein kinase, putative | 0.0035 | 0.0037 | 0.0277 |
Schistosoma mansoni | protein kinase | 0.0058 | 0.1325 | 1 |
Echinococcus multilocularis | serine:threonine protein kinase PAK 3 | 0.0058 | 0.1325 | 0.1628 |
Echinococcus multilocularis | serine:threonine protein kinase PAK 3 | 0.0058 | 0.1325 | 0.1628 |
Trichomonas vaginalis | STE family protein kinase | 0.0058 | 0.1325 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0057 | 0.1288 | 0.1288 |
Echinococcus granulosus | p21 activated protein kinase 1 Dpak1 | 0.0058 | 0.1325 | 0.1628 |
Trichomonas vaginalis | STE family protein kinase | 0.0058 | 0.1325 | 1 |
Echinococcus multilocularis | p21 activated protein kinase 1 Dpak1 | 0.0058 | 0.1325 | 0.1628 |
Trichomonas vaginalis | STE family protein kinase | 0.0058 | 0.1325 | 1 |
Entamoeba histolytica | p21-activated kinase | 0.0058 | 0.1325 | 1 |
Giardia lamblia | Kinase, STE STE20 | 0.0058 | 0.1325 | 0.5 |
Trichomonas vaginalis | STE family protein kinase | 0.0058 | 0.1325 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (ADMET) | > 100 uM | Cytotoxicity against human THP1 cells using cell count reagent SF | ChEMBL. | 21524580 |
ED50 (functional) | = 12.3 uM | Immunomodulatory activity in human THP1 cells assessed as differentiation of monocyte to macrophage after 4 days by MTT assay | ChEMBL. | 21524580 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.