Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Candida albicans | beta-1,3-glucan synthase similar to S. cerevisiae GSC2 (YGR032W) and FKS1 (YLR342W) beta-1,3-glucan synthase | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | matrixin family protein | 0.0178 | 0.4509 | 1 |
Toxoplasma gondii | 1,3-beta-glucan synthase component protein | 0.0256 | 0.9295 | 0.5 |
Schistosoma mansoni | matrix metallopeptidase-9 (M10 family) | 0.0175 | 0.4315 | 1 |
Onchocerca volvulus | Matrilysin homolog | 0.0163 | 0.3607 | 1 |
Brugia malayi | Matrixin family protein | 0.0178 | 0.4509 | 1 |
Onchocerca volvulus | Matrix metalloproteinase homolog | 0.0163 | 0.3607 | 1 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.