Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | euchromatic histone-lysine N-methyltransferase 2 | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Trichomonas vaginalis | set domain proteins, putative | Get druggable targets OG5_131470 | All targets in OG5_131470 |
Onchocerca volvulus | Get druggable targets OG5_131470 | All targets in OG5_131470 | |
Brugia malayi | Pre-SET motif family protein | Get druggable targets OG5_131470 | All targets in OG5_131470 |
Loa Loa (eye worm) | pre-SET domain-containing protein family protein | Get druggable targets OG5_131470 | All targets in OG5_131470 |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Toxoplasma gondii | clathrin heavy chain, putative | 0.0118 | 0.1646 | 0.5 |
Entamoeba histolytica | clathrin heavy chain, putative | 0.0285 | 0.6208 | 1 |
Entamoeba histolytica | clathrin heavy chain, putative | 0.0227 | 0.463 | 0.7459 |
Trypanosoma brucei | clathrin heavy chain, putative | 0.0257 | 0.5438 | 1 |
Onchocerca volvulus | 0.0286 | 0.6245 | 0.5 | |
Leishmania major | clathrin heavy chain, putative | 0.0257 | 0.5438 | 0.5 |
Giardia lamblia | Clathrin heavy chain | 0.0118 | 0.1646 | 0.5 |
Trypanosoma cruzi | clathrin heavy chain, putative | 0.0257 | 0.5438 | 1 |
Plasmodium vivax | clathrin heavy chain, putative | 0.0285 | 0.6208 | 0.5 |
Schistosoma mansoni | clathrin heavy chain | 0.0118 | 0.1646 | 0.5 |
Plasmodium falciparum | clathrin heavy chain, putative | 0.0225 | 0.4562 | 0.5 |
Trichomonas vaginalis | clathrin heavy chain, putative | 0.0067 | 0.0253 | 0.0405 |
Schistosoma mansoni | clathrin heavy chain | 0.0118 | 0.1646 | 0.5 |
Trichomonas vaginalis | set domain proteins, putative | 0.0286 | 0.6245 | 1 |
Trypanosoma brucei | clathrin heavy chain | 0.0257 | 0.5438 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 1 uM | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504404] | ChEMBL. | No reference |
Potency (functional) | 14.7157 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Potency (functional) | 31.6228 uM | PUBCHEM_BIOASSAY: qHTS assay for re-activators of p53 using a Luc reporter. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504709] | ChEMBL. | No reference |
Potency (functional) | 39.8107 uM | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of JMJD2A-Tudor Domain. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID504402] | ChEMBL. | No reference |
Potency (functional) | 84.3679 uM | PubChem BioAssay. qHTS for Inhibitors of PLK1-PDB (polo-like kinase 1 - polo-box domain): Primary Screen. (Class of assay: confirmatory) | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Plasmodium falciparum | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.