Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | arachidonate 5-lipoxygenase | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Schistosoma mansoni | lipoxygenase | Get druggable targets OG5_127482 | All targets in OG5_127482 |
Echinococcus multilocularis | arachidonate 5 lipoxygenase | Get druggable targets OG5_127482 | All targets in OG5_127482 |
Schistosoma japonicum | ko:K00461 arachidonate 5-lipoxygenase [EC1.13.11.34], putative | Get druggable targets OG5_127482 | All targets in OG5_127482 |
Schistosoma mansoni | lipoxygenase | Get druggable targets OG5_127482 | All targets in OG5_127482 |
Schistosoma japonicum | IPR001024,Lipoxygenase, LH2;IPR013819,Lipoxygenase, C-terminal,domain-containing | Get druggable targets OG5_127482 | All targets in OG5_127482 |
Echinococcus granulosus | arachidonate 5 lipoxygenase | Get druggable targets OG5_127482 | All targets in OG5_127482 |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | vesicular acetylcholine transporter | 0.0214 | 0.2669 | 1 |
Trypanosoma brucei | C-8 sterol isomerase, putative | 0.0359 | 0.6021 | 0.5 |
Echinococcus granulosus | vesicular acetylcholine transporter | 0.0214 | 0.2669 | 0.2583 |
Echinococcus granulosus | arachidonate 5 lipoxygenase | 0.0142 | 0.0996 | 0.089 |
Echinococcus multilocularis | arachidonate 5 lipoxygenase | 0.0142 | 0.0996 | 0.089 |
Onchocerca volvulus | Vesicular acetylcholine transporter homolog | 0.0214 | 0.2669 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0359 | 0.6021 | 1 |
Loa Loa (eye worm) | vesicular acetylcholine transporter unc-17 | 0.0214 | 0.2669 | 0.1775 |
Schistosoma mansoni | lipoxygenase | 0.0142 | 0.0996 | 0.3732 |
Brugia malayi | ERG2 and Sigma1 receptor like protein | 0.0359 | 0.6021 | 1 |
Echinococcus multilocularis | vesicular acetylcholine transporter | 0.0214 | 0.2669 | 0.2583 |
Leishmania major | C-8 sterol isomerase-like protein | 0.0359 | 0.6021 | 0.5 |
Trypanosoma cruzi | C-8 sterol isomerase, putative | 0.0359 | 0.6021 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 0.23 uM | Inhibition of 5-lipoxygenase in S100 supernatant assessed as inhibition of LTB4 production preincubated for 15 mins measured after 10 mins by HPLC method | ChEMBL. | 21341744 |
IC50 (binding) | = 0.23 uM | Inhibition of 5-lipoxygenase in S100 supernatant assessed as inhibition of (5(S)-hydroperoxy-6-trans-8,11,14-cis-eicosatetraenoic acid production preincubated for 15 mins measured after 10 mins by HPLC method | ChEMBL. | 21341744 |
IC50 (binding) | = 0.4 uM | Inhibition of 5-lipoxygenase in human polymorphonuclear leukocytes assessed as inhibition of LTB4 production preincubated for 15 mins measured after 10 mins by HPLC method | ChEMBL. | 21341744 |
IC50 (binding) | = 0.4 uM | Inhibition of 5-lipoxygenase in human polymorphonuclear leukocytes assessed as inhibition of (5(S)-hydroperoxy-6-trans-8,11,14-cis-eicosatetraenoic acid production preincubated for 15 mins measured after 10 mins by HPLC method | ChEMBL. | 21341744 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.