Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Escherichia coli | Dihydrofolate reductase | Starlite/ChEMBL | References |
Escherichia coli | Thymidylate synthase (EC 2.1.1.45) (TS) (TSase) | Starlite/ChEMBL | References |
Homo sapiens | thymidylate synthetase | Starlite/ChEMBL | References |
Homo sapiens | dihydrofolate reductase | Starlite/ChEMBL | References |
Toxoplasma gondii | bifunctional dihydrofolate reductase-thymidylate synthase | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | thymidylate synthase | 0.051 | 0.6783 | 1 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0099 | 0.0536 | 0.079 |
Loa Loa (eye worm) | hypothetical protein | 0.0099 | 0.0536 | 0.079 |
Trichomonas vaginalis | conserved hypothetical protein | 0.034 | 0.4199 | 0.5 |
Brugia malayi | dihydrofolate reductase family protein | 0.034 | 0.4204 | 0.6197 |
Schistosoma mansoni | hypothetical protein | 0.0067 | 0.0062 | 0.0092 |
Schistosoma mansoni | dihydrofolate reductase | 0.034 | 0.4204 | 0.6197 |
Loa Loa (eye worm) | thymidylate synthase | 0.051 | 0.6783 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0067 | 0.0062 | 0.0092 |
Mycobacterium tuberculosis | Probable thymidylate synthase ThyA (ts) (TSASE) | 0.051 | 0.6783 | 1 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0099 | 0.0536 | 0.079 |
Brugia malayi | thymidylate synthase | 0.051 | 0.6783 | 1 |
Chlamydia trachomatis | dihydrofolate reductase | 0.034 | 0.4204 | 0.5 |
Schistosoma mansoni | bifunctional dihydrofolate reductase-thymidylate synthase | 0.051 | 0.6783 | 1 |
Mycobacterium ulcerans | thymidylate synthase | 0.051 | 0.6783 | 1 |
Brugia malayi | Dihydrofolate reductase | 0.034 | 0.4204 | 0.6197 |
Echinococcus multilocularis | dihydrofolate reductase | 0.034 | 0.4204 | 0.6197 |
Onchocerca volvulus | 0.051 | 0.6783 | 0.5 | |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0067 | 0.0062 | 0.0092 |
Mycobacterium leprae | PROBABLE THYMIDYLATE SYNTHASE THYA (TS) (TSASE) | 0.051 | 0.6783 | 1 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0099 | 0.0536 | 0.079 |
Loa Loa (eye worm) | dihydrofolate reductase | 0.034 | 0.4204 | 0.6197 |
Echinococcus granulosus | thymidylate synthase | 0.051 | 0.6783 | 1 |
Echinococcus granulosus | dihydrofolate reductase | 0.034 | 0.4204 | 0.6197 |
Mycobacterium tuberculosis | Dihydrofolate reductase DfrA (DHFR) (tetrahydrofolate dehydrogenase) | 0.034 | 0.4204 | 0.002 |
Brugia malayi | hypothetical protein | 0.034 | 0.4199 | 0.619 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 0.017 uM | Inhibition of Escherichia coli TS assessed as oxidation of tetrahydrofolate to dihydrofolate after 2 to 12 mins by spectrophotometry | ChEMBL. | 21550809 |
IC50 (binding) | = 0.02 uM | Inhibition of Toxoplasma gondii DHFR by spectrophotometry | ChEMBL. | 21550809 |
IC50 (binding) | = 0.068 uM | Inhibition of human TS assessed as oxidation of tetrahydrofolate to dihydrofolate after 2 to 12 mins by spectrophotometry | ChEMBL. | 21550809 |
IC50 (binding) | = 0.09 uM | Inhibition of human DHFR by spectrophotometry | ChEMBL. | 21550809 |
IC50 (binding) | = 0.14 uM | Inhibition of Toxoplasma gondii TS assessed as oxidation of tetrahydrofolate to dihydrofolate after 2 to 12 mins by spectrophotometry | ChEMBL. | 21550809 |
IC50 (binding) | = 0.4 uM | Inhibition of Escherichia coli DHFR by spectrophotometry | ChEMBL. | 21550809 |
Ratio IC50 (binding) | = 50 | Ratio of premetrexed IC50 to compound IC50 for human TS | ChEMBL. | 21550809 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.