Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma cruzi | Biotin--acetyl-CoA-carboxylase ligase, putative | 0.0345 | 0.0755 | 0.5 |
Mycobacterium ulcerans | bifunctional protein BirA | 0.0704 | 0.9245 | 0.5 |
Echinococcus multilocularis | biotin protein ligase | 0.0345 | 0.0755 | 1 |
Entamoeba histolytica | biotin--acetyl-CoA-carboxylase ligase, putative | 0.0345 | 0.0755 | 1 |
Chlamydia trachomatis | biotin synthetase | 0.0345 | 0.0755 | 1 |
Echinococcus multilocularis | biotin protein ligase | 0.0345 | 0.0755 | 1 |
Wolbachia endosymbiont of Brugia malayi | biotin-(acetyl-CoA carboxylase) ligase | 0.0345 | 0.0755 | 0.5 |
Leishmania major | biotin/lipoate protein ligase-like protein | 0.0345 | 0.0755 | 0.5 |
Trypanosoma brucei | Biotin--acetyl-CoA-carboxylase ligase, putative | 0.0345 | 0.0755 | 0.5 |
Plasmodium vivax | biotin--[acetyl-CoA-carboxylase] synthetase, putative | 0.0345 | 0.0755 | 0.5 |
Brugia malayi | biotin--acetyl-CoA-carboxylase ligase family protein | 0.0345 | 0.0755 | 0.5 |
Trypanosoma cruzi | Biotin--acetyl-CoA-carboxylase ligase, putative | 0.0345 | 0.0755 | 0.5 |
Plasmodium falciparum | biotin protein ligase, putative | 0.0345 | 0.0755 | 0.5 |
Loa Loa (eye worm) | biotin protein ligase 1 | 0.0345 | 0.0755 | 1 |
Giardia lamblia | Hypothetical protein | 0.0345 | 0.0755 | 0.5 |
Plasmodium falciparum | biotin--acetyl-CoA-carboxylase, putative | 0.0345 | 0.0755 | 0.5 |
Schistosoma mansoni | biotin-protein ligase | 0.0345 | 0.0755 | 1 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.