Detailed information for compound 1513589

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 706.66 | Formula: C33H45Cl2N7O6
  • H donors: 5 H acceptors: 5 LogP: 1.65 Rotable bonds: 24
    Rule of 5 violations (Lipinski): 2
  • SMILES: CNCCCNC(=O)COCC(=O)NCC(=O)NCC(=O)Nc1cccc(c1)[C@H](N(C(=O)Cc1ccc(c(c1)Cl)Cl)C)CN1CCCC1
  • InChi: 1S/C33H45Cl2N7O6/c1-36-11-6-12-37-31(45)21-48-22-32(46)39-18-29(43)38-19-30(44)40-25-8-5-7-24(17-25)28(20-42-13-3-4-14-42)41(2)33(47)16-23-9-10-26(34)27(35)15-23/h5,7-10,15,17,28,36H,3-4,6,11-14,16,18-22H2,1-2H3,(H,37,45)(H,38,43)(H,39,46)(H,40,44)/t28-/m1/s1
  • InChiKey: CMTAFJFUXXXHCL-MUUNZHRXSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0081 0.0351 0.0734
Schistosoma mansoni nAChR subunit 0.0081 0.0351 0.0734
Loa Loa (eye worm) hypothetical protein 0.0081 0.0351 0.0741
Loa Loa (eye worm) hypothetical protein 0.0243 0.1658 0.3501
Schistosoma mansoni opsin-like receptor 0.0243 0.1658 0.3471
Schistosoma mansoni biogenic amine receptor 0.0243 0.1658 0.3471
Loa Loa (eye worm) hypothetical protein 0.0243 0.1658 0.3501
Brugia malayi Trypsin family protein 0.0094 0.0455 0.0961
Brugia malayi hypothetical protein 0.0094 0.0455 0.0961
Onchocerca volvulus 0.0243 0.1658 0.3501
Echinococcus granulosus 7tm_1 domain containing protein 0.0243 0.1658 0.1658
Schistosoma mansoni hypothetical protein 0.0243 0.1658 0.3471
Echinococcus granulosus neuropeptides capa receptor 0.0243 0.1658 0.1658
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0081 0.0351 0.0741
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0243 0.1658 0.3471
Echinococcus multilocularis g protein coupled receptor 0.0243 0.1658 0.1658
Toxoplasma gondii hypothetical protein 0.009 0.0427 0.0476
Onchocerca volvulus 0.0243 0.1658 0.3501
Leishmania major protein kinase, putative 0.0059 0.0173 1
Schistosoma mansoni growth hormone secretagogue receptor 0.0243 0.1658 0.3471
Toxoplasma gondii PAN domain-containing protein 0.009 0.0427 0.0476
Schistosoma mansoni nAChR subunit 0.0081 0.0351 0.0734
Echinococcus granulosus nicotinic acetylcholine receptor alpha subunit 0.0151 0.0919 0.0919
Entamoeba histolytica serine/threonine- protein kinase 6 , putative 0.0059 0.0173 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0243 0.1658 0.3471
Mycobacterium ulcerans hypothetical protein 0.0094 0.0455 0.5
Loa Loa (eye worm) hypothetical protein 0.0043 0.005 0.0105
Loa Loa (eye worm) hypothetical protein 0.0243 0.1658 0.3501
Echinococcus multilocularis glycoprotein Antigen 5 0.0094 0.0455 0.0455
Onchocerca volvulus 0.0243 0.1658 0.3501
Loa Loa (eye worm) GABA receptor subunit 0.0043 0.005 0.0105
Loa Loa (eye worm) hypothetical protein 0.009 0.0427 0.0901
Brugia malayi serine/threonine-protein kinase 6 0.0059 0.0173 0.0366
Loa Loa (eye worm) hypothetical protein 0.0243 0.1658 0.3501
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0243 0.1658 0.3471
Loa Loa (eye worm) hypothetical protein 0.0243 0.1658 0.3501
Loa Loa (eye worm) hypothetical protein 0.0081 0.0351 0.0741
Loa Loa (eye worm) PAN domain-containing protein 0.009 0.0427 0.0901
Schistosoma mansoni nAChR subunit (ShAR1-alpha-like) 0.0258 0.1783 0.3733
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0243 0.1658 0.1658
Onchocerca volvulus 0.0243 0.1658 0.3501
Echinococcus granulosus glycine receptor subunit beta 0.0081 0.0351 0.0351
Onchocerca volvulus 0.009 0.0427 0.0901
Toxoplasma gondii microneme protein MIC17A 0.009 0.0427 0.0476
Echinococcus multilocularis rhodopsin orphan GPCR 0.0243 0.1658 0.1658
Onchocerca volvulus 0.009 0.0427 0.0901
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0081 0.0351 0.0351
Onchocerca volvulus 0.0243 0.1658 0.3501
Loa Loa (eye worm) hypothetical protein 0.0043 0.005 0.0105
Echinococcus granulosus serine:threonine protein kinase 12 B 0.0059 0.0173 0.0173
Loa Loa (eye worm) TK/EPH protein kinase 0.0082 0.0363 0.0766
Onchocerca volvulus 0.009 0.0427 0.0901
Echinococcus granulosus G protein coupled receptor 139 0.0243 0.1658 0.1658
Brugia malayi excitatory GABA receptor EXP-1A 0.0081 0.0351 0.0741
Brugia malayi sulfakinin receptor protein 0.0243 0.1658 0.3501
Echinococcus granulosus g-protein coupled receptor 0.0243 0.1658 0.1658
Brugia malayi Tachykinin-like peptides receptor 99D 0.0243 0.1658 0.3501
Loa Loa (eye worm) hypothetical protein 0.0243 0.1658 0.3501
Loa Loa (eye worm) LGC-31 protein 0.0081 0.0351 0.0741
Loa Loa (eye worm) hypothetical protein 0.0043 0.005 0.0105
Schistosoma mansoni cercarial elastase (S01 family) 0.0094 0.0455 0.0953
Schistosoma mansoni hypothetical protein 0.0243 0.1658 0.3471
Toxoplasma gondii hypothetical protein 0.009 0.0427 0.0476
Schistosoma mansoni amine GPCR 0.0243 0.1658 0.3471
Loa Loa (eye worm) acetylcholine receptor alpha subunit 0.0081 0.0351 0.0741
Toxoplasma gondii PAN domain-containing protein 0.0964 0.7481 1
Schistosoma mansoni hypothetical protein 0.0094 0.0455 0.0953
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0243 0.1658 0.3501
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0243 0.1658 0.1658
Loa Loa (eye worm) hypothetical protein 0.0243 0.1658 0.3501
Schistosoma mansoni cercarial elastase (S01 family) 0.0094 0.0455 0.0953
Brugia malayi PAN domain containing protein 0.009 0.0427 0.0901
Entamoeba histolytica protein kinase, putative 0.0059 0.0173 1
Onchocerca volvulus 0.0258 0.1783 0.3764
Loa Loa (eye worm) PAN domain-containing protein 0.009 0.0427 0.0901
Loa Loa (eye worm) hypothetical protein 0.0081 0.0351 0.0741
Echinococcus granulosus neuropeptide s receptor 0.0243 0.1658 0.1658
Onchocerca volvulus 0.0243 0.1658 0.3501
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0081 0.0351 0.0351
Echinococcus multilocularis nicotinic acetylcholine receptor a11 subunit 0.0151 0.0919 0.0919
Echinococcus multilocularis fmrfamide receptor 0.0243 0.1658 0.1658
Echinococcus multilocularis serotonin receptor 0.0243 0.1658 0.1658
Echinococcus multilocularis rhodopsin orphan GPCR 0.0243 0.1658 0.1658
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0081 0.0351 0.0741
Onchocerca volvulus 0.0243 0.1658 0.3501
Schistosoma mansoni serine/threonine protein kinase 0.0059 0.0173 0.0363
Schistosoma mansoni cercarial elastase (S01 family) 0.0094 0.0455 0.0953
Brugia malayi Trypsin family protein 0.0094 0.0455 0.0961
Brugia malayi hypothetical protein 0.0243 0.1658 0.3501
Brugia malayi neuropeptide F receptor 0.0243 0.1658 0.3501
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0243 0.1658 0.3471
Loa Loa (eye worm) hypothetical protein 0.0081 0.0351 0.0741
Brugia malayi Trypsin family protein 0.0624 0.4737 1
Echinococcus granulosus tm gpcr rhodopsin 0.0243 0.1658 0.1658
Echinococcus granulosus glycine receptor subunit alpha 1 0.0081 0.0351 0.0351
Trichomonas vaginalis AGC family protein kinase 0.0059 0.0173 0.5
Echinococcus multilocularis neuronal acetylcholine receptor subunit alpha 4 0.0081 0.0351 0.0351
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0243 0.1658 0.1658
Echinococcus granulosus nAChR subunit 0.0081 0.0351 0.0351
Trypanosoma brucei aurora B kinase 0.0059 0.0173 0.5
Brugia malayi PAN domain containing protein 0.009 0.0427 0.0901
Schistosoma mansoni ephrin receptor 0.0065 0.0221 0.0463
Echinococcus granulosus orexin receptor type 2 0.0243 0.1658 0.1658
Echinococcus multilocularis g-protein coupled receptor 0.0243 0.1658 0.1658
Echinococcus granulosus somatostatin receptor 0.0243 0.1658 0.1658
Onchocerca volvulus 0.0081 0.0351 0.0741
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0043 0.005 0.0105
Loa Loa (eye worm) hypothetical protein 0.0243 0.1658 0.3501
Loa Loa (eye worm) hypothetical protein 0.0081 0.0351 0.0741
Loa Loa (eye worm) hypothetical protein 0.0624 0.4737 1
Brugia malayi hypothetical protein 0.0243 0.1658 0.3501
Loa Loa (eye worm) neuropeptide F receptor 0.0243 0.1658 0.3501
Schistosoma mansoni neuropeptide receptor 0.0243 0.1658 0.3471
Onchocerca volvulus 0.0094 0.0455 0.0961
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0243 0.1658 0.1658
Brugia malayi PAN domain containing protein 0.009 0.0427 0.0901
Brugia malayi hypothetical protein 0.0243 0.1658 0.3501
Onchocerca volvulus 0.0094 0.0455 0.0961
Brugia malayi nicotinic acetylcholine receptor beta-1 chain precursor 0.0081 0.0351 0.0741
Loa Loa (eye worm) excitatory GABA receptor EXP-1A 0.0081 0.0351 0.0741
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0243 0.1658 0.1658
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0094 0.0455 0.0953
Echinococcus multilocularis serine:threonine protein kinase 12 B 0.0059 0.0173 0.0173
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0081 0.0351 0.0741
Echinococcus granulosus tissue type plasminogen activator 0.0046 0.0074 0.0074
Echinococcus granulosus subfamily S1A unassigned peptidase S01 family 0.0094 0.0455 0.0455
Brugia malayi acetylcholine receptor protein, alpha-like chain, putative 0.0081 0.0351 0.0741
Onchocerca volvulus 0.009 0.0427 0.0901
Toxoplasma gondii PAN/Apple domain-containing protein 0.009 0.0427 0.0476
Schistosoma mansoni nAChR subunit 0.0081 0.0351 0.0734
Loa Loa (eye worm) hypothetical protein 0.0624 0.4737 1
Brugia malayi putative neuropeptide receptor NPR1 0.0243 0.1658 0.3501
Echinococcus multilocularis transmembrane protease serine 3 0.0094 0.0455 0.0455
Echinococcus multilocularis neuropeptides capa receptor 0.0243 0.1658 0.1658
Echinococcus multilocularis rhodopsin orphan GPCR 0.0243 0.1658 0.1658
Trichomonas vaginalis AGC family protein kinase 0.0059 0.0173 0.5
Echinococcus granulosus neuropeptide receptor A26 0.0243 0.1658 0.1658
Loa Loa (eye worm) ligand-Gated ion Channel family member 0.0081 0.0351 0.0741
Schistosoma mansoni nAChR subunit (ShAR1-beta-like) 0.0258 0.1783 0.3733
Echinococcus multilocularis fmrfamide receptor 0.0243 0.1658 0.1658
Echinococcus granulosus rhodopsin orphan GPCR 0.0243 0.1658 0.1658
Loa Loa (eye worm) hypothetical protein 0.0243 0.1658 0.3501
Loa Loa (eye worm) hypothetical protein 0.0081 0.0351 0.0741
Entamoeba histolytica protein kinase , putative 0.0059 0.0173 1
Onchocerca volvulus 0.009 0.0427 0.0901
Loa Loa (eye worm) PAN domain-containing protein 0.009 0.0427 0.0901
Schistosoma mansoni cercarial elastase (S01 family) 0.0094 0.0455 0.0953
Echinococcus granulosus 7TM GPCR rhodopsin 0.0243 0.1658 0.1658
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0243 0.1658 0.3471
Brugia malayi serine/threonine protein kinase 6 0.0059 0.0173 0.0366
Echinococcus granulosus hypothetical protein 0.0243 0.1658 0.1658
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0243 0.1658 0.1658
Onchocerca volvulus 0.0043 0.005 0.0105
Schistosoma mansoni opsin-like receptor 0.0243 0.1658 0.3471
Loa Loa (eye worm) hypothetical protein 0.0243 0.1658 0.3501
Loa Loa (eye worm) hypothetical protein 0.009 0.0427 0.0901
Entamoeba histolytica serine/threonine protein kinase 6, putative 0.0059 0.0173 1
Brugia malayi Cation transporter family protein 0.0081 0.0351 0.0741
Trypanosoma cruzi aurora B kinase, putative 0.0059 0.0173 1
Echinococcus multilocularis somatostatin receptor 0.0243 0.1658 0.1658
Schistosoma mansoni cercarial elastase (S01 family) 0.0094 0.0455 0.0953
Echinococcus granulosus Peptidase S1 S6 chymotrypsin Hap 0.0094 0.0455 0.0455
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0081 0.0351 0.0741
Loa Loa (eye worm) hypothetical protein 0.0081 0.0351 0.0741
Schistosoma mansoni nicotinic acetylcholine receptor alpha 0.0043 0.005 0.0104
Schistosoma mansoni amine GPCR 0.0243 0.1658 0.3471
Brugia malayi PAN domain containing protein 0.009 0.0427 0.0901
Toxoplasma gondii microneme protein MIC4 0.009 0.0427 0.0476
Echinococcus multilocularis ephrin type A receptor 4 A 0.0065 0.0221 0.0221
Brugia malayi Kringle domain containing protein 0.0046 0.0074 0.0156
Onchocerca volvulus 0.0258 0.1783 0.3764
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0243 0.1658 0.1658
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0081 0.0351 0.0734
Schistosoma mansoni nAChR subunit (ShAR1-beta2-like) 0.0081 0.0351 0.0734
Echinococcus granulosus nicotinic acetylcholine receptor beta 1 subunit 0.0081 0.0351 0.0351
Loa Loa (eye worm) hypothetical protein 0.0243 0.1658 0.3501
Loa Loa (eye worm) hypothetical protein 0.0043 0.005 0.0105
Schistosoma mansoni opsin-like receptor 0.0243 0.1658 0.3471
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0243 0.1658 0.1658
Brugia malayi G-protein coupled receptor 0.0243 0.1658 0.3501
Echinococcus multilocularis G-protein coupled receptor, putative 0.0243 0.1658 0.1658
Echinococcus granulosus nicotinic acetylcholine receptor subunit type 0.0081 0.0351 0.0351
Onchocerca volvulus 0.0243 0.1658 0.3501
Loa Loa (eye worm) hypothetical protein 0.0081 0.0351 0.0741
Brugia malayi PAN domain containing protein 0.009 0.0427 0.0901
Onchocerca volvulus 0.0258 0.1783 0.3764
Onchocerca volvulus 0.0243 0.1658 0.3501
Echinococcus granulosus transmembrane protease serine 3 0.0094 0.0455 0.0455
Schistosoma mansoni biogenic amine receptor 0.0243 0.1658 0.3471
Loa Loa (eye worm) hypothetical protein 0.0243 0.1658 0.3501
Loa Loa (eye worm) hypothetical protein 0.0243 0.1658 0.3501
Echinococcus multilocularis neuropeptides capa receptor 0.0243 0.1658 0.1658
Echinococcus granulosus dro:myosuppressin receptor 0.0243 0.1658 0.1658
Echinococcus granulosus nAChR subunit 0.0043 0.005 0.005
Echinococcus granulosus neuropeptide Y receptor 0.0243 0.1658 0.1658
Echinococcus granulosus g protein coupled receptor 0.0243 0.1658 0.1658
Brugia malayi G protein-coupled receptor 0.0243 0.1658 0.3501
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0243 0.1658 0.3471
Loa Loa (eye worm) hypothetical protein 0.009 0.0427 0.0901
Loa Loa (eye worm) hypothetical protein 0.009 0.0427 0.0901
Onchocerca volvulus 0.009 0.0427 0.0901
Loa Loa (eye worm) hypothetical protein 0.0243 0.1658 0.3501
Loa Loa (eye worm) hypothetical protein 0.0243 0.1658 0.3501
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0094 0.0455 0.0953
Echinococcus multilocularis acetylcholine receptor subunit beta 1 0.0081 0.0351 0.0351
Loa Loa (eye worm) hypothetical protein 0.0043 0.005 0.0105
Echinococcus granulosus aurora kinase A 0.0059 0.0173 0.0173
Schistosoma mansoni amine GPCR 0.0243 0.1658 0.3471
Loa Loa (eye worm) hypothetical protein 0.0221 0.1482 0.3128
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0243 0.1658 0.1658
Entamoeba histolytica protein kinase domain containing protein 0.0059 0.0173 1
Echinococcus multilocularis neuropeptide s receptor 0.0243 0.1658 0.1658
Onchocerca volvulus 0.0243 0.1658 0.3501
Echinococcus granulosus serotonin receptor 0.0243 0.1658 0.1658
Brugia malayi Serotonin receptor 0.0243 0.1658 0.3501
Brugia malayi gamma-aminobutyric-acid receptor beta subunit precursor 0.0081 0.0351 0.0741
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0243 0.1658 0.1658
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0243 0.1658 0.3471
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0243 0.1658 0.3471
Loa Loa (eye worm) hypothetical protein 0.0243 0.1658 0.3501
Onchocerca volvulus 0.0624 0.4737 1
Onchocerca volvulus 0.009 0.0427 0.0901
Loa Loa (eye worm) neuropeptide F receptor 0.0243 0.1658 0.3501
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0081 0.0351 0.0351
Brugia malayi Chymotrypsin-like protease CTRL-1 precursor 0.0094 0.0455 0.0961
Echinococcus multilocularis orexin receptor type 2 0.0243 0.1658 0.1658
Loa Loa (eye worm) hypothetical protein 0.0094 0.0455 0.0961
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0243 0.1658 0.3471
Plasmodium falciparum serine/threonine protein kinase, putative 0.0059 0.0173 1
Onchocerca volvulus Putative nachr subunit 0.0151 0.0919 0.1941
Echinococcus granulosus biogenic amine 5HT receptor 0.0243 0.1658 0.1658
Loa Loa (eye worm) hypothetical protein 0.0243 0.1658 0.3501
Loa Loa (eye worm) hypothetical protein 0.0243 0.1658 0.3501
Loa Loa (eye worm) hypothetical protein 0.0043 0.005 0.0105
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0243 0.1658 0.1658
Loa Loa (eye worm) hypothetical protein 0.0243 0.1658 0.3501
Loa Loa (eye worm) hypothetical protein 0.0094 0.0455 0.0961
Loa Loa (eye worm) hypothetical protein 0.0094 0.0455 0.0961
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0094 0.0455 0.0953
Echinococcus multilocularis nicotinic acetylcholine receptor beta 1 subunit 0.0081 0.0351 0.0351
Brugia malayi PAN domain containing protein 0.009 0.0427 0.0901
Loa Loa (eye worm) hypothetical protein 0.0094 0.0455 0.0961
Brugia malayi Cation transporter family protein 0.0258 0.1783 0.3764
Schistosoma mansoni hypothetical protein 0.0046 0.0074 0.0155
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0243 0.1658 0.1658
Echinococcus multilocularis g protein coupled receptor 0.0243 0.1658 0.1658
Brugia malayi PAN domain containing protein 0.009 0.0427 0.0901
Brugia malayi Hypothetical glycine receptor like protein T20B12.9 in chromosome III 0.0081 0.0351 0.0741
Loa Loa (eye worm) hypothetical protein 0.0243 0.1658 0.3501
Toxoplasma gondii aurora kinase 0.0059 0.0173 0.0134
Echinococcus granulosus rhodopsin orphan GPCR 0.0243 0.1658 0.1658
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0094 0.0455 0.0953
Brugia malayi hypothetical protein 0.0243 0.1658 0.3501
Loa Loa (eye worm) hypothetical protein 0.0043 0.005 0.0105
Echinococcus multilocularis neuropeptide receptor 0.0243 0.1658 0.1658
Loa Loa (eye worm) hypothetical protein 0.0243 0.1658 0.3501
Loa Loa (eye worm) hypothetical protein 0.0243 0.1658 0.3501
Schistosoma mansoni histamine h1 receptor 0.0243 0.1658 0.3471
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0243 0.1658 0.3501
Brugia malayi RE15519p 0.0243 0.1658 0.3501
Loa Loa (eye worm) PAN domain-containing protein 0.009 0.0427 0.0901
Echinococcus multilocularis rhodopsin orphan GPCR 0.0243 0.1658 0.1658
Loa Loa (eye worm) hypothetical protein 0.0243 0.1658 0.3501
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0243 0.1658 0.3471
Echinococcus granulosus peptide allatostatin:somatostatin 0.0243 0.1658 0.1658
Echinococcus multilocularis neuropeptide Y receptor 0.0243 0.1658 0.1658
Echinococcus granulosus rhodopsin orphan GPCR 0.0243 0.1658 0.1658
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0243 0.1658 0.3501
Schistosoma mansoni cercarial elastase (S01 family) 0.0094 0.0455 0.0953
Toxoplasma gondii subtilisin SUB12 0.009 0.0427 0.0476
Echinococcus granulosus neuropeptides capa receptor 0.0243 0.1658 0.1658
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0243 0.1658 0.3501
Schistosoma mansoni hypothetical protein 0.0094 0.0455 0.0953
Brugia malayi ORL1-like opioid receptor 0.0243 0.1658 0.3501
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0243 0.1658 0.3471
Brugia malayi Dopamine receptor 0.0243 0.1658 0.3501
Echinococcus granulosus Mastin 0.0094 0.0455 0.0455
Loa Loa (eye worm) hypothetical protein 0.0081 0.0351 0.0741
Plasmodium vivax serine/threonine protein kinase 6, putative 0.0059 0.0173 1
Loa Loa (eye worm) hypothetical protein 0.0243 0.1658 0.3501
Onchocerca volvulus 0.009 0.0427 0.0901
Echinococcus multilocularis nAChR subunit 0.0081 0.0351 0.0351
Toxoplasma gondii microneme protein, putative 0.009 0.0427 0.0476
Echinococcus multilocularis Cys loop ligand gated ion channel subunit 0.0081 0.0351 0.0351
Loa Loa (eye worm) hypothetical protein 0.0243 0.1658 0.3501
Loa Loa (eye worm) hypothetical protein 0.0081 0.0351 0.0741
Echinococcus multilocularis g protein coupled receptor 0.0243 0.1658 0.1658
Echinococcus multilocularis enteropeptidase 0.0094 0.0455 0.0455
Echinococcus multilocularis neuropeptide Y receptor 0.0243 0.1658 0.1658
Loa Loa (eye worm) hypothetical protein 0.0081 0.0351 0.0741
Loa Loa (eye worm) AUR protein kinase 0.0059 0.0173 0.0366
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0243 0.1658 0.3501
Echinococcus granulosus rhodopsin orphan GPCR 0.0243 0.1658 0.1658
Echinococcus multilocularis rhodopsin orphan GPCR 0.0243 0.1658 0.1658
Brugia malayi follicle stimulating hormone receptor 0.0243 0.1658 0.3501
Echinococcus granulosus ephrin type A receptor 4 A 0.0065 0.0221 0.0221
Onchocerca volvulus 0.0243 0.1658 0.3501
Schistosoma mansoni hypothetical protein 0.0243 0.1658 0.3471
Loa Loa (eye worm) AUR protein kinase 0.0059 0.0173 0.0366
Echinococcus multilocularis neuropeptide receptor A26 0.0243 0.1658 0.1658
Loa Loa (eye worm) TK/ROR protein kinase 0.0047 0.008 0.0168
Echinococcus granulosus rhodopsin orphan GPCR 0.0243 0.1658 0.1658
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0081 0.0351 0.0741
Onchocerca volvulus 0.0243 0.1658 0.3501
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0243 0.1658 0.3501
Trichomonas vaginalis AGC family protein kinase 0.0059 0.0173 0.5
Echinococcus multilocularis rhodopsin orphan GPCR 0.0243 0.1658 0.1658
Loa Loa (eye worm) hypothetical protein 0.0094 0.0455 0.0961
Echinococcus multilocularis rhodopsin orphan GPCR 0.0243 0.1658 0.1658
Loa Loa (eye worm) hypothetical protein 0.0243 0.1658 0.3501
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0043 0.005 0.0105
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0081 0.0351 0.0741
Echinococcus multilocularis neuropeptide receptor 0.0243 0.1658 0.1658
Echinococcus multilocularis glycine receptor subunit beta 0.0081 0.0351 0.0351
Onchocerca volvulus 0.0243 0.1658 0.3501
Loa Loa (eye worm) hypothetical protein 0.0243 0.1658 0.3501
Onchocerca volvulus 0.0043 0.005 0.0105
Loa Loa (eye worm) hypothetical protein 0.0243 0.1658 0.3501
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0243 0.1658 0.3471
Echinococcus multilocularis nicotinic acetylcholine receptor alpha subunit 0.0151 0.0919 0.0919
Brugia malayi Trypsin-like protease protein 5 0.0094 0.0455 0.0961
Loa Loa (eye worm) hypothetical protein 0.0243 0.1658 0.3501
Loa Loa (eye worm) hypothetical protein 0.0258 0.1783 0.3764
Schistosoma mansoni nAChR subunit 0.0081 0.0351 0.0734
Loa Loa (eye worm) nicotinic acetylcholine receptor non-alpha subunit 0.0081 0.0351 0.0741
Echinococcus granulosus sex peptide receptor 0.0243 0.1658 0.1658
Brugia malayi hypothetical protein 0.0243 0.1658 0.3501
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0243 0.1658 0.1658
Schistosoma mansoni alpha-1 adrenergic receptor 0.0243 0.1658 0.3471
Loa Loa (eye worm) hypothetical protein 0.0243 0.1658 0.3501
Loa Loa (eye worm) hypothetical protein 0.0243 0.1658 0.3501
Echinococcus granulosus neuropeptide FF receptor 2 0.0243 0.1658 0.1658
Schistosoma mansoni neuropeptide receptor 0.0243 0.1658 0.3471
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0243 0.1658 0.3471
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0243 0.1658 0.3501
Brugia malayi nicotinic acetylcholine receptor alpha subunit, putative 0.0151 0.0919 0.1941
Onchocerca volvulus 0.0243 0.1658 0.3501
Brugia malayi PAN domain containing protein 0.009 0.0427 0.0901
Echinococcus multilocularis nAChR subunit 0.0043 0.005 0.005
Echinococcus granulosus g protein coupled receptor 0.0243 0.1658 0.1658
Echinococcus granulosus biogenic amine 5HT receptor 0.0243 0.1658 0.1658
Echinococcus granulosus glycine receptor subunit beta 0.0081 0.0351 0.0351
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0243 0.1658 0.3471
Echinococcus granulosus tachykinin peptides receptor 99D 0.0243 0.1658 0.1658
Echinococcus granulosus neuropeptide Y receptor 0.0243 0.1658 0.1658
Onchocerca volvulus 0.0081 0.0351 0.0741
Schistosoma mansoni nAChR subunit 0.0081 0.0351 0.0734
Schistosoma mansoni neuropeptide f receptor 76f 0.0243 0.1658 0.3471
Loa Loa (eye worm) hypothetical protein 0.009 0.0427 0.0901
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0243 0.1658 0.3471
Schistosoma mansoni protein kinase 0.0059 0.0173 0.0363
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0243 0.1658 0.3471
Loa Loa (eye worm) G-protein coupled receptor 0.0243 0.1658 0.3501
Echinococcus multilocularis tissue type plasminogen activator 0.0046 0.0074 0.0074
Echinococcus multilocularis allatostatin A receptor 0.0243 0.1658 0.1658
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0243 0.1658 0.1658
Schistosoma mansoni amine GPCR 0.0243 0.1658 0.3471
Echinococcus granulosus allatostatin A receptor 0.0243 0.1658 0.1658
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0043 0.005 0.0104
Trichomonas vaginalis AGC family protein kinase 0.0059 0.0173 0.5
Schistosoma mansoni neuropeptide receptor 0.0243 0.1658 0.3471
Echinococcus multilocularis nicotinic acetylcholine receptor subunit alpha 8 0.0151 0.0919 0.0919
Schistosoma mansoni neurotransmitter gated ion channel 0.0043 0.005 0.0104
Loa Loa (eye worm) hypothetical protein 0.0243 0.1658 0.3501
Echinococcus multilocularis sex peptide receptor 0.0243 0.1658 0.1658
Echinococcus granulosus nicotinic acetylcholine receptor subunit alpha 8 0.0151 0.0919 0.0919
Giardia lamblia Aurora kinase 0.0059 0.0173 0.5
Schistosoma mansoni biogenic amine (5HT) receptor 0.0243 0.1658 0.3471
Echinococcus multilocularis dro:myosuppressin receptor 0.0243 0.1658 0.1658
Echinococcus granulosus Cys loop ligand gated ion channel subunit 0.0081 0.0351 0.0351
Loa Loa (eye worm) hypothetical protein 0.009 0.0427 0.0901
Toxoplasma gondii PAN domain-containing protein 0.009 0.0427 0.0476
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0629 0.4777 1
Loa Loa (eye worm) ACC-1 protein 0.0081 0.0351 0.0741
Echinococcus granulosus nicotinic acetylcholine receptor a11 subunit 0.0151 0.0919 0.0919
Echinococcus multilocularis rhodopsin orphan GPCR 0.0243 0.1658 0.1658
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0243 0.1658 0.3471
Toxoplasma gondii microneme protein MIC17B 0.009 0.0427 0.0476
Loa Loa (eye worm) hypothetical protein 0.0243 0.1658 0.3501
Echinococcus granulosus alpha 1A adrenergic receptor 0.0243 0.1658 0.1658
Echinococcus granulosus neuropeptide receptor 0.0243 0.1658 0.1658
Schistosoma mansoni neuropeptide receptor 0.0243 0.1658 0.3471
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0243 0.1658 0.3501
Echinococcus granulosus neuropeptide receptor 0.0243 0.1658 0.1658
Echinococcus multilocularis G protein coupled receptor 139 0.0243 0.1658 0.1658
Brugia malayi hypothetical protein 0.0243 0.1658 0.3501
Loa Loa (eye worm) hypothetical protein 0.0243 0.1658 0.3501
Loa Loa (eye worm) glutamate-gated chloride channel alpha3A subunit 0.0081 0.0351 0.0741
Loa Loa (eye worm) hypothetical protein 0.0243 0.1658 0.3501
Brugia malayi hypothetical protein 0.0243 0.1658 0.3501
Loa Loa (eye worm) hypothetical protein 0.0064 0.0216 0.0455
Schistosoma mansoni nAChR subunit 0.0081 0.0351 0.0734
Schistosoma mansoni cercarial elastase (S01 family) 0.0094 0.0455 0.0953
Brugia malayi Dopamine receptor protein 2 0.0243 0.1658 0.3501
Onchocerca volvulus 0.0094 0.0455 0.0961
Onchocerca volvulus 0.0064 0.0216 0.0455
Onchocerca volvulus 0.0243 0.1658 0.3501
Onchocerca volvulus Neuropeptide F receptor homolog 0.0243 0.1658 0.3501
Loa Loa (eye worm) hypothetical protein 0.0243 0.1658 0.3501
Schistosoma mansoni adenoreceptor 0.0243 0.1658 0.3471
Brugia malayi G-protein coupled receptor 0.0243 0.1658 0.3501
Loa Loa (eye worm) ACC-1 protein 0.0081 0.0351 0.0741
Loa Loa (eye worm) hypothetical protein 0.0151 0.0919 0.1941
Loa Loa (eye worm) hypothetical protein 0.0243 0.1658 0.3501
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0243 0.1658 0.3471
Schistosoma mansoni hypothetical protein 0.0243 0.1658 0.3471
Brugia malayi glutamate-gated chloride channel alpha3A subunit, putative 0.0043 0.005 0.0105
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0243 0.1658 0.1658
Toxoplasma gondii PAN domain-containing protein 0.0964 0.7481 1
Onchocerca volvulus 0.0094 0.0455 0.0961
Loa Loa (eye worm) nicotinic acetylcholine receptor alpha subunit 0.0151 0.0919 0.1941
Echinococcus multilocularis neuropeptide FF receptor 2 0.0243 0.1658 0.1658
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0081 0.0351 0.0741
Onchocerca volvulus 0.0094 0.0455 0.0961
Schistosoma mansoni myosin xvIII 0.0243 0.1658 0.3471
Onchocerca volvulus 0.009 0.0427 0.0901
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0081 0.0351 0.0741
Echinococcus multilocularis serotonin receptor 0.0243 0.1658 0.1658
Echinococcus granulosus glycine receptor subunit alpha 1 0.0081 0.0351 0.0351
Brugia malayi Trypsin family protein 0.0094 0.0455 0.0961
Brugia malayi Melatonin receptor type 1A 0.0243 0.1658 0.3501
Schistosoma mansoni aminopeptidase PILS (M01 family) 0.0094 0.0455 0.0953
Loa Loa (eye worm) AUR protein kinase 0.0059 0.0173 0.0366
Schistosoma mansoni cercarial elastase (S01 family) 0.0094 0.0455 0.0953
Echinococcus multilocularis aurora kinase A 0.0059 0.0173 0.0173
Brugia malayi hypothetical protein 0.0243 0.1658 0.3501
Loa Loa (eye worm) hypothetical protein 0.009 0.0427 0.0901
Echinococcus granulosus enteropeptidase 0.0094 0.0455 0.0455
Loa Loa (eye worm) hypothetical protein 0.0043 0.005 0.0105
Brugia malayi AKH receptor 0.0243 0.1658 0.3501
Echinococcus granulosus g protein coupled receptor 0.0243 0.1658 0.1658
Loa Loa (eye worm) hypothetical protein 0.0258 0.1783 0.3764
Loa Loa (eye worm) G-protein coupled receptor 0.0243 0.1658 0.3501
Schistosoma mansoni cercarial elastase (S01 family) 0.0094 0.0455 0.0953
Loa Loa (eye worm) hypothetical protein 0.0081 0.0351 0.0741
Entamoeba histolytica serine/threonine- protein kinase 6, putative 0.0059 0.0173 1
Brugia malayi GnHR receptor homolog 0.0243 0.1658 0.3501
Loa Loa (eye worm) PAN domain-containing protein 0.009 0.0427 0.0901
Echinococcus granulosus fmrfamide receptor 0.0243 0.1658 0.1658
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0243 0.1658 0.3471
Loa Loa (eye worm) hypothetical protein 0.0046 0.0074 0.0156
Onchocerca volvulus 0.053 0.398 0.8403
Schistosoma mansoni cercarial elastase (S01 family) 0.0094 0.0455 0.0953
Loa Loa (eye worm) trypsin family protein 0.0094 0.0455 0.0961
Brugia malayi Dopamine receptor protein 1 0.0243 0.1658 0.3501
Echinococcus granulosus tm gpcr rhodopsin 0.0243 0.1658 0.1658
Toxoplasma gondii PAN domain-containing protein 0.009 0.0427 0.0476
Loa Loa (eye worm) hypothetical protein 0.0243 0.1658 0.3501
Brugia malayi hypothetical protein 0.0243 0.1658 0.3501
Brugia malayi PAN domain containing protein 0.009 0.0427 0.0901
Onchocerca volvulus 0.0243 0.1658 0.3501
Echinococcus multilocularis glycine receptor subunit beta 0.0081 0.0351 0.0351
Loa Loa (eye worm) hypothetical protein 0.0243 0.1658 0.3501
Echinococcus granulosus acetylcholine receptor subunit beta 1 0.0081 0.0351 0.0351
Loa Loa (eye worm) hypothetical protein 0.0081 0.0351 0.0741
Toxoplasma gondii PAN domain-containing protein 0.009 0.0427 0.0476
Loa Loa (eye worm) TYRA-2 protein 0.0243 0.1658 0.3501
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0243 0.1658 0.3471
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0243 0.1658 0.3501
Loa Loa (eye worm) hypothetical protein 0.0243 0.1658 0.3501
Brugia malayi G protein-coupled receptor F59B2.13 0.0243 0.1658 0.3501
Schistosoma mansoni neuropeptide F-like receptor 0.0243 0.1658 0.3471
Loa Loa (eye worm) hypothetical protein 0.0081 0.0351 0.0741
Brugia malayi Serotonin receptor 0.0243 0.1658 0.3501
Brugia malayi serine/threonine kinase 12 0.0059 0.0173 0.0366
Schistosoma mansoni amine GPCR 0.0243 0.1658 0.3471
Loa Loa (eye worm) hypothetical protein 0.0243 0.1658 0.3501
Brugia malayi putative neuropeptide receptor 0.0243 0.1658 0.3501
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0243 0.1658 0.1658
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0243 0.1658 0.3501
Brugia malayi Hypothetical glycine receptor like protein T20B12.9 in chromosome III 0.0043 0.005 0.0105
Echinococcus multilocularis subfamily S1A unassigned peptidase (S01 family) 0.0094 0.0455 0.0455
Loa Loa (eye worm) hypothetical protein 0.0243 0.1658 0.3501
Loa Loa (eye worm) hypothetical protein 0.0243 0.1658 0.3501
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0081 0.0351 0.0741
Brugia malayi hypothetical protein 0.0243 0.1658 0.3501
Schistosoma mansoni neuropeptide F-like receptor 0.0243 0.1658 0.3471
Onchocerca volvulus 0.009 0.0427 0.0901
Loa Loa (eye worm) melatonin receptor type 1A 0.0243 0.1658 0.3501
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0243 0.1658 0.1658
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0243 0.1658 0.3471
Onchocerca volvulus 0.0243 0.1658 0.3501
Onchocerca volvulus 0.0046 0.0074 0.0156
Schistosoma mansoni cercarial elastase (S01 family) 0.0094 0.0455 0.0953
Entamoeba histolytica protein kinase, putative 0.0059 0.0173 1
Schistosoma mansoni biogenic amine receptor 0.0243 0.1658 0.3471
Loa Loa (eye worm) hypothetical protein 0.0243 0.1658 0.3501
Schistosoma mansoni nAChR subunit 0.0081 0.0351 0.0734
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0094 0.0455 0.0953
Schistosoma mansoni biogenic amine (5HT) receptor 0.0243 0.1658 0.3471
Echinococcus multilocularis Mastin 0.0094 0.0455 0.0455
Onchocerca volvulus 0.009 0.0427 0.0901
Brugia malayi acetylcholine receptor alpha subunit precursor, putative 0.0081 0.0351 0.0741
Echinococcus granulosus rhodopsin orphan GPCR 0.0243 0.1658 0.1658
Echinococcus multilocularis Peptidase S1 S6, chymotrypsin Hap 0.0094 0.0455 0.0455
Brugia malayi neuropeptide F receptor 0.0243 0.1658 0.3501
Loa Loa (eye worm) hypothetical protein 0.0243 0.1658 0.3501
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0081 0.0351 0.0734
Brugia malayi Protein kinase domain containing protein 0.0047 0.008 0.0168
Echinococcus granulosus glycine receptor subunit alpha 1 0.0081 0.0351 0.0351
Brugia malayi acetylcholine receptor, alpha-type subunit unc-38 precursor 0.0081 0.0351 0.0741
Brugia malayi PAN domain containing protein 0.009 0.0427 0.0901
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0243 0.1658 0.1658
Echinococcus granulosus neuronal acetylcholine receptor subunit alpha 4 0.0081 0.0351 0.0351
Onchocerca volvulus 0.0081 0.0351 0.0741
Brugia malayi larval opioid receptor 0.0243 0.1658 0.3501
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0243 0.1658 0.3501
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0624 0.4737 0.9916
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0243 0.1658 0.1658
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0243 0.1658 0.3471
Loa Loa (eye worm) hypothetical protein 0.0081 0.0351 0.0741
Loa Loa (eye worm) hypothetical protein 0.0081 0.0351 0.0741
Brugia malayi Cation transporter family protein 0.0081 0.0351 0.0741
Echinococcus granulosus glycoprotein Antigen 5 0.0094 0.0455 0.0455
Toxoplasma gondii microneme protein MIC17C 0.009 0.0427 0.0476
Echinococcus granulosus rhodopsin orphan GPCR 0.0243 0.1658 0.1658
Toxoplasma gondii 1,3(4)-beta-glucanase 0.009 0.0427 0.0476

Activities

Activity type Activity value Assay description Source Reference
ED50 (functional) = 0.0045 nmol Antinociceptive activity in intrathecally dosed HSD:ICR(CD1) mouse by tail flick test ChEMBL. 24936231
ED50 (functional) = 0.58 nmol Antinociceptive activity in icv dosed HSD:ICR(CD1) mouse by tail flick test ChEMBL. 24936231

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.