Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hexokinase | 0.0337 | 0.4604 | 0.4604 |
Brugia malayi | hexokinase type II | 0.0171 | 0.0123 | 0.0123 |
Loa Loa (eye worm) | hypothetical protein | 0.0171 | 0.0123 | 0.0123 |
Trichomonas vaginalis | histone deacetylase, putative | 0.0235 | 0.1859 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0366 | 0.5396 | 0.5396 |
Trichomonas vaginalis | histone deacetylase, putative | 0.0235 | 0.1859 | 0.5 |
Brugia malayi | histone deacetylase 1 (HD1) | 0.0235 | 0.1859 | 0.1859 |
Trichomonas vaginalis | histone deacetylase, putative | 0.0235 | 0.1859 | 0.5 |
Trichomonas vaginalis | histone deacetylase, putative | 0.0235 | 0.1859 | 0.5 |
Trichomonas vaginalis | histone deacetylase, putative | 0.0235 | 0.1859 | 0.5 |
Trichomonas vaginalis | histone deacetylase 1, 2 ,3, putative | 0.0235 | 0.1859 | 0.5 |
Trichomonas vaginalis | histone deacetylase 1, 2 ,3, putative | 0.0235 | 0.1859 | 0.5 |
Trichomonas vaginalis | histone deacetylase 1, 2 ,3, putative | 0.0235 | 0.1859 | 0.5 |
Brugia malayi | Histone deacetylase 1 | 0.0235 | 0.1859 | 0.1859 |
Loa Loa (eye worm) | histone deacetylase 1 | 0.0235 | 0.1859 | 0.1859 |
Giardia lamblia | Histone deacetylase | 0.0235 | 0.1859 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0235 | 0.1859 | 0.1859 |
Loa Loa (eye worm) | histone deacetylase 3 | 0.0235 | 0.1859 | 0.1859 |
Loa Loa (eye worm) | hypothetical protein | 0.0171 | 0.0123 | 0.0123 |
Brugia malayi | Hexokinase family protein | 0.0337 | 0.4604 | 0.4604 |
Trichomonas vaginalis | histone deacetylase, putative | 0.0235 | 0.1859 | 0.5 |
Brugia malayi | histone deacetylase 3 (HD3) | 0.0235 | 0.1859 | 0.1859 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (ADMET) | = 2 % | Cytotoxicity against human CEM cells expressing green fluorescent protein assessed as cell viability at 100 ug after 48 hrs by MTT assay | ChEMBL. | 21339030 |
Activity (ADMET) | = 37 % | Cytotoxicity against human CEM cells expressing green fluorescent protein assessed as cell viability at 50 ug after 48 hrs by MTT assay | ChEMBL. | 21339030 |
Activity (ADMET) | = 74 % | Cytotoxicity against human CEM cells expressing green fluorescent protein assessed as cell viability at 20 ug after 48 hrs by MTT assay | ChEMBL. | 21339030 |
Activity (ADMET) | = 94 % | Cytotoxicity against human CEM cells expressing green fluorescent protein assessed as cell viability at 10 ug after 48 hrs by MTT assay | ChEMBL. | 21339030 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.