Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | baculoviral IAP repeat containing 3 | Starlite/ChEMBL | References |
Homo sapiens | X-linked inhibitor of apoptosis, E3 ubiquitin protein ligase | Starlite/ChEMBL | References |
Homo sapiens | baculoviral IAP repeat containing 2 | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | phosphatidylinositol 3 | 0.1096 | 0.7864 | 1 |
Schistosoma mansoni | phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K | 0.0611 | 0.304 | 0.2348 |
Entamoeba histolytica | phosphatidylinositol 3-kinase, putative | 0.0611 | 0.304 | 0.2348 |
Echinococcus multilocularis | phosphatidylinositol 4 phosphate 3 kinase C2 | 0.094 | 0.6315 | 0.5949 |
Brugia malayi | Phosphatidylinositol 3- and 4-kinase family protein | 0.0611 | 0.304 | 0.0684 |
Echinococcus granulosus | phosphatidylinositol 4 phosphate 3 kinase C2 | 0.094 | 0.6315 | 0.5949 |
Entamoeba histolytica | phosphatidylinositol 4-kinase, putative | 0.0559 | 0.2529 | 0.1786 |
Echinococcus multilocularis | phosphatidylinositol 4 kinase alpha | 0.0559 | 0.2529 | 0.1786 |
Trichomonas vaginalis | phosphatidylinositol 3-kinase class, putative | 0.0981 | 0.6725 | 0.6399 |
Trypanosoma brucei | phosphatidylinositol 3-kinase, putative | 0.0611 | 0.304 | 1 |
Trypanosoma cruzi | phosphatidylinositol 3-kinase vps34-like | 0.0611 | 0.304 | 0.1139 |
Loa Loa (eye worm) | phosphatidylinositol 4-kinase type 3 alpha isoform 1 | 0.0559 | 0.2529 | 0.26 |
Trichomonas vaginalis | phosphatidylinositol 3-kinase class, putative | 0.0611 | 0.304 | 0.2348 |
Echinococcus granulosus | phosphatidylinositol 4 kinase alpha | 0.0559 | 0.2529 | 0.1786 |
Trichomonas vaginalis | phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative | 0.0611 | 0.304 | 0.2348 |
Trypanosoma cruzi | phosphatidylinositol 4-kinase alpha, putative | 0.0559 | 0.2529 | 0.0487 |
Plasmodium vivax | phosphatidylinositol 3-kinase, putative | 0.0396 | 0.0904 | 0.5 |
Leishmania major | phosphatidylinositol 4-kinase alpha, putative | 0.0559 | 0.2529 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.094 | 0.6315 | 0.7852 |
Trichomonas vaginalis | phosphatidylinositol 4-kinase, putative | 0.0559 | 0.2529 | 0.1786 |
Entamoeba histolytica | phosphatidylinositol 3-kinase, putative | 0.0725 | 0.4179 | 0.3601 |
Toxoplasma gondii | phosphatidylinositol 3- and 4-kinase | 0.0396 | 0.0904 | 0.5 |
Entamoeba histolytica | phosphatidylinositol 3-kinase, putative | 0.0611 | 0.304 | 0.2348 |
Entamoeba histolytica | phosphatidylinositol 3-kinase, putative | 0.1096 | 0.7864 | 0.7652 |
Brugia malayi | Phosphatidylinositol 3- and 4-kinase family protein | 0.094 | 0.6315 | 0.5068 |
Toxoplasma gondii | phosphatidylinositol 3- and 4-kinase | 0.0396 | 0.0904 | 0.5 |
Trichomonas vaginalis | phosphatidylinositol kinase, putative | 0.0559 | 0.2529 | 0.1786 |
Entamoeba histolytica | phosphatidylinositol 3-kinase 1, putative | 0.1221 | 0.9106 | 0.9017 |
Plasmodium falciparum | phosphatidylinositol 3-kinase | 0.0396 | 0.0904 | 0.5 |
Trichomonas vaginalis | phosphatidylinositol kinase, putative | 0.0611 | 0.304 | 0.2348 |
Giardia lamblia | Phosphoinositide-3-kinase, catalytic, alpha polypeptide | 0.0766 | 0.4589 | 1 |
Entamoeba histolytica | hypothetical protein | 0.1096 | 0.7864 | 0.7652 |
Schistosoma mansoni | phosphatidylinositol 4-kinase | 0.0559 | 0.2529 | 0.1786 |
Trypanosoma cruzi | phosphatidylinositol 4-kinase alpha, putative | 0.0559 | 0.2529 | 0.0487 |
Loa Loa (eye worm) | phosphatidylinositol 3 | 0.0521 | 0.2146 | 0.2069 |
Trichomonas vaginalis | phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative | 0.0981 | 0.6725 | 0.6399 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (ADMET) | Toxicity in SCID mouse xenografted with human MDA-MB-231 cells assessed as weight loss at 5 mg/kg, iv administered on day 1 to 5 and 8 to 12 post tumor implantation | ChEMBL. | 21462933 | |
Activity (functional) | = 269 mm3 | Antitumor activity against human MDA-MB-231 cells xenografted in SCID mouse assessed as tumor size at 5 mg/kg, iv administered on day 1 to 5 and 8 to 12 post tumor implantation measured on day 50 (Rvb = 1136 mm'3) | ChEMBL. | 21462933 |
IC50 (binding) | = 4.9 nM | Competitive inhibition of human cIAP1 BIR3 domain after 2 to 3 hrs by fluorescence polarization assay | ChEMBL. | 21462933 |
IC50 (binding) | = 5.4 nM | Competitive inhibition of human XIAP linker BIR2-BIR3 domain expressed in Escherichia coli BL21(DE3) cells by fluorescence polarization-based assay | ChEMBL. | 21462933 |
IC50 (binding) | = 7.4 nM | Competitive inhibition of human cIAP1BIR2-BIR3 domain after 2 to 3 hrs by fluorescence polarization assay | ChEMBL. | 21462933 |
IC50 (binding) | = 11 nM | Competitive inhibition of human cIAP2 BIR3 domain after 2 to 3 hrs by fluorescence polarization assay | ChEMBL. | 21462933 |
IC50 (functional) | = 19.6 nM | Growth inhibition of human MDA-MB-231 cells after 2 to 3 hrs by WST8 assay | ChEMBL. | 21462933 |
IC50 (binding) | = 212 nM | Competitive inhibition of His-tagged human XIAP BIR3 domain expressed in Escherichia coli BL21(DE3) after 2 to 3 hrs by fluorescence polarization assay | ChEMBL. | 21462933 |
Ki (binding) | = 1 nM | Binding affinity to human XIAP linker BIR2-BIR3 domain expressed in Escherichia coli BL21(DE3) cells by fluorescence polarization-based assay | ChEMBL. | 21462933 |
Ki (binding) | < 1 nM | Binding affinity to human cIAP1 BIR3 domain after 2 to 3 hrs by fluorescence polarization-based assay | ChEMBL. | 21462933 |
Ki (binding) | = 2 nM | Binding affinity to human cIAP1 BIR2-BIR3 domain after 2 to 3 hrs by fluorescence polarization-based assay | ChEMBL. | 21462933 |
Ki (binding) | = 2.5 nM | Binding affinity to human cIAP2 BIR3 domain after 2 to 3 hrs by fluorescence polarization-based assay | ChEMBL. | 21462933 |
Ki (binding) | = 63 nM | Binding affinity to His-tagged human XIAP BIR3 domain expressed in Escherichia coli BL21(DE3) after 2 to 3 hrs by fluorescence polarization-based assay | ChEMBL. | 21462933 |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Homo sapiens | ChEMBL23 | 21462933 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.