Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma cruzi | DNA topoisomerase II, putative | 0.0145 | 0.0977 | 0.1791 |
Plasmodium falciparum | DNA topoisomerase 2 | 0.0208 | 0.1747 | 0.1747 |
Trypanosoma brucei | mitochondrial DNA polymerase beta-PAK | 0.0142 | 0.0944 | 0.1731 |
Trypanosoma cruzi | mitochondrial DNA topoisomerase II, putative | 0.0516 | 0.5455 | 1 |
Plasmodium vivax | DNA topoisomerase II, putative | 0.0208 | 0.1747 | 0.1747 |
Onchocerca volvulus | DNA topoisomerase 2 homolog | 0.0208 | 0.1747 | 1 |
Brugia malayi | Cytochrome P450 family protein | 0.0116 | 0.0625 | 0.358 |
Toxoplasma gondii | DNA topoisomerase 2, putative | 0.0208 | 0.1747 | 0.3202 |
Chlamydia trachomatis | DNA gyrase subunit B | 0.0585 | 0.6292 | 0.6292 |
Trypanosoma brucei | DNA topoisomerase II beta, putative | 0.0145 | 0.0977 | 0.1791 |
Mycobacterium ulcerans | hypothetical protein | 0.0158 | 0.1138 | 0.1138 |
Trypanosoma brucei | mitochondrial DNA polymerase beta | 0.03 | 0.2852 | 0.5229 |
Brugia malayi | DNA gyrase/topoisomerase IV, A subunit family protein | 0.0208 | 0.1747 | 1 |
Trichomonas vaginalis | DNA topoisomerase II, putative | 0.0208 | 0.1747 | 1 |
Trypanosoma cruzi | DNA topoisomerase II, putative | 0.0145 | 0.0977 | 0.1791 |
Trypanosoma cruzi | mitochondrial DNA topoisomerase II, putative | 0.0516 | 0.5455 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0145 | 0.0977 | 0.5592 |
Entamoeba histolytica | DNA topoisomerase II, putative | 0.0208 | 0.1747 | 1 |
Trypanosoma cruzi | mitochondrial DNA polymerase beta-PAK, putative | 0.0142 | 0.0944 | 0.1731 |
Echinococcus multilocularis | endonuclease exonuclease phosphatase | 0.0187 | 0.1484 | 0.8497 |
Echinococcus granulosus | DNA topoisomerase 2 alpha | 0.0208 | 0.1747 | 1 |
Trypanosoma cruzi | mitochondrial DNA polymerase beta, putative | 0.03 | 0.2852 | 0.5229 |
Loa Loa (eye worm) | TOPoisomerase family member | 0.0208 | 0.1747 | 1 |
Toxoplasma gondii | ATPase/histidine kinase/DNA gyrase B/HSP90 domain-containing protein | 0.0516 | 0.5455 | 1 |
Trypanosoma cruzi | mitochondrial DNA polymerase beta, putative | 0.03 | 0.2852 | 0.5229 |
Leishmania major | mitochondrial DNA topoisomerase II | 0.0516 | 0.5455 | 1 |
Trypanosoma brucei | DNA topoisomerase ii | 0.0516 | 0.5455 | 1 |
Trypanosoma brucei | DNA topoisomerase II alpha, putative | 0.0145 | 0.0977 | 0.1791 |
Leishmania major | DNA topoisomerase ii | 0.0145 | 0.0977 | 0.1791 |
Schistosoma mansoni | hypothetical protein | 0.0288 | 0.2708 | 1 |
Brugia malayi | Probable DNA topoisomerase II | 0.0208 | 0.1747 | 1 |
Schistosoma mansoni | DNA topoisomerase II | 0.0208 | 0.1747 | 0.6452 |
Onchocerca volvulus | DNA topoisomerase 2 homolog | 0.0208 | 0.1747 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0145 | 0.0977 | 0.5592 |
Mycobacterium leprae | Probable DNA gyrase (subunit B) GyrB (DNA topoisomerase (ATP-hydrolysing)) (DNA topoisomerase II) (Type II DNA topoisomerase) | 0.0307 | 0.2938 | 1 |
Brugia malayi | DNA topoisomerase II, alpha isozyme | 0.0208 | 0.1747 | 1 |
Onchocerca volvulus | Putative DNA topoisomerase 2, mitochondrial | 0.0208 | 0.1747 | 1 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0116 | 0.0625 | 0.358 |
Echinococcus granulosus | endonuclease exonuclease phosphatase | 0.0187 | 0.1484 | 0.8497 |
Leishmania major | mitochondrial DNA polymerase beta | 0.03 | 0.2852 | 0.5229 |
Giardia lamblia | DNA topoisomerase II | 0.018 | 0.1409 | 1 |
Echinococcus multilocularis | DNA topoisomerase 2 alpha | 0.0208 | 0.1747 | 1 |
Leishmania major | mitochondrial DNA polymerase beta-PAK, putative | 0.0142 | 0.0944 | 0.1731 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.