Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | cytochrome P450, family 19, subfamily A, polypeptide 1 | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Trypanosoma cruzi | cytochrome P450, putative | cytochrome P450, family 19, subfamily A, polypeptide 1 | 503 aa | 425 aa | 18.8 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | integrin alpha 3 | 0.0741 | 0.4222 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0761 | 0.4376 | 0.4195 |
Brugia malayi | Integrin alpha pat-2 precursor | 0.0993 | 0.6162 | 1 |
Schistosoma mansoni | integrin alpha-ps | 0.0485 | 0.2252 | 0.3654 |
Brugia malayi | Integrin alpha cytoplasmic region family protein | 0.0732 | 0.415 | 0.6082 |
Schistosoma mansoni | integrin alpha | 0.0993 | 0.6162 | 1 |
Echinococcus granulosus | integrin alpha ps | 0.0485 | 0.2252 | 0.496 |
Echinococcus multilocularis | integrin alpha ps | 0.0485 | 0.2252 | 0.496 |
Echinococcus granulosus | integrin beta 2 | 0.0241 | 0.038 | 0.0173 |
Echinococcus multilocularis | integrin alpha ps | 0.0485 | 0.2252 | 0.496 |
Schistosoma mansoni | hypothetical protein | 0.0232 | 0.0312 | 0.0507 |
Loa Loa (eye worm) | hypothetical protein | 0.0252 | 0.0466 | 0.0159 |
Loa Loa (eye worm) | hypothetical protein | 0.0732 | 0.415 | 0.3962 |
Echinococcus multilocularis | integrin beta 2 | 0.0241 | 0.038 | 0.0173 |
Loa Loa (eye worm) | integrin beta-2 | 0.0326 | 0.1029 | 0.0739 |
Schistosoma mansoni | integrin alpha-ps | 0.0252 | 0.0466 | 0.0757 |
Echinococcus multilocularis | integrin alpha 3 | 0.0741 | 0.4222 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0509 | 0.2437 | 0.2193 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 0.034 uM | Inhibition of aromatase in human placental microsomes assessed as inhibition of aromatization of [1,2,6,7-3H] androstenedione by flow scintillation analysis | ChEMBL. | 21497425 |
IC50 (binding) | = 0.078 uM | Inhibition of aromatase in human placental microsomes assessed as inhibition of aromatization of [1,2,6,7-3H] androstenedione by flow scintillation analysis | ChEMBL. | 21497425 |
IC50 (binding) | = 0.534 uM | Inhibition of aromatase in human placental microsomes assessed as inhibition of aromatization of [1,2,6,7-3H] androstenedione by flow scintillation analysis | ChEMBL. | 21497425 |
Ratio IC50 (binding) | = 11 | Inhibition of aromatase in human placental microsomes assessed as inhibition of aromatization of [1,2,6,7-3H] androstenedione by flow scintillation analysis relative to aminoglutethimide | ChEMBL. | 21497425 |
Ratio IC50 (binding) | = 74 | Inhibition of aromatase in human placental microsomes assessed as inhibition of aromatization of [1,2,6,7-3H] androstenedione by flow scintillation analysis relative to aminoglutethimide | ChEMBL. | 21497425 |
Ratio IC50 (binding) | = 170 | Inhibition of aromatase in human placental microsomes assessed as inhibition of aromatization of [1,2,6,7-3H] androstenedione by flow scintillation analysis relative to aminoglutethimide | ChEMBL. | 21497425 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.